sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks Genz-123346

Genz-123346

CAS No.:
491833-30-8
Catalog Number:
AG00DB8L
Molecular Formula:
C24H38N2O4
Molecular Weight:
418.5695
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$210
- +
10mg
99%
1 week
United States
$265
- +
25mg
99%
1 week
United States
$460
- +
50mg
99%
1 week
United States
$682
- +
Product Description
Catalog Number:
AG00DB8L
Chemical Name:
Genz-123346
CAS Number:
491833-30-8
Molecular Formula:
C24H38N2O4
Molecular Weight:
418.5695
MDL Number:
MFCD22419854
IUPAC Name:
N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]nonanamide
InChI:
InChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1
InChI Key:
JMNXWOFCUJJYEO-HYBUGGRVSA-N
SMILES:
CCCCCCCCC(=O)NC(C(c1ccc2c(c1)OCCO2)O)CN1CCCC1
Properties
Complexity:
498  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
418.283g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
418.578g/mol
Monoisotopic Mass:
418.283g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
71A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2  
Literature
Title Journal
A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2. Pediatric research 20110501
Glycosphingolipids and insulin resistance. Advances in experimental medicine and biology 20110101
Lipids and renal cystic disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101101
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma. International immunology 20100701
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nature medicine 20100701
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. Journal of medicinal chemistry 20100128
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice. Hepatology (Baltimore, Md.) 20090701
Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes 20070501
Properties