Name: Name:Genz-644282
Brand: Angene
SKU: AG00DB66
Rating: 90 (10 reviews)

Genz-644282

CAS No.:

529488-28-6

Catalog Number:

AG00DB66

Molecular Formula:

C22H21N3O5

Molecular Weight:

407.4192

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

1mg

≥98%

1 week

United States

$101

- +

5mg

98%

1 week

United States

$257

- +

10mg

98%

1 week

United States

$423

- +

25mg

≥98%

1 week

United States

$890

- +

50mg

98%

1 week

United States

$923

- +

100mg

98%

1 week

United States

$1623

- +

Product Description

Catalog Number:

AG00DB66

Chemical Name:

Genz-644282

CAS Number:

529488-28-6

Molecular Formula:

C22H21N3O5

Molecular Weight:

407.4192

MDL Number:

MFCD25976816

IUPAC Name:

16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.02,10.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaen-20-one

InChI:

InChI=1S/C22H21N3O5/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26/h6-10,23H,4-5,11H2,1-3H3

InChI Key:

BAORCAMWLWRZQG-UHFFFAOYSA-N

SMILES:

CNCCn1c(=O)c2cc(OC)c(cc2c2c1c1cc3OCOc3cc1nc2)OC

UNII:

717I541I2R

Properties

Complexity:

636

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

407.148g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

407.426g/mol

Monoisotopic Mass:

407.148g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

82.2A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

2.2

Literature

Title	Journal
Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.	Pediatric blood & cancer 20120201
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.	Molecular cancer therapeutics 20110801
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.	Clinical cancer research : an official journal of the American Association for Cancer Research 20110501
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.	Journal of medicinal chemistry 20050210

Properties