IKK Inhibitor III, BMS-345541
| Title | Journal |
|---|---|
| Evaluation of low doses BPA-induced perturbation of glycemia by toxicogenomics points to a primary role of pancreatic islets and to the mechanism of toxicity. | Cell death & disease 20151001 |
| Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. | The Journal of biological chemistry 20140808 |
| PDGF-D expression is down-regulated by TGFβ in fibroblasts. | PloS one 20140101 |
| Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. | Experimental cell research 20130401 |
| Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. | Apoptosis : an international journal on programmed cell death 20130201 |
| Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20120801 |
| Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-κB. | Journal of leukocyte biology 20120401 |
| Targeting IKK/NF-κB pathway reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. | Neuroscience letters 20120305 |
| IκB kinases modulate the activity of the androgen receptor in prostate carcinoma cell lines. | Neoplasia (New York, N.Y.) 20120301 |
| Activation of the IκB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination. | Journal of biochemistry 20111201 |
| Comprehensive analysis of kinase inhibitor selectivity. | Nature biotechnology 20111030 |
| Targeting AML through DR4 with a novel variant of rhTRAIL. | Journal of cellular and molecular medicine 20111001 |
| Kinase inhibitors modulate huntingtin cell localization and toxicity. | Nature chemical biology 20110529 |
| AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts. | The Journal of biological chemistry 20110506 |
| Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB activity in pancreatic islets depends on oxygen availability. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110201 |
| Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. | Bioorganic & medicinal chemistry letters 20110101 |
| IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. | PloS one 20110101 |
| IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. | PloS one 20110101 |
| Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. | Chemistry & biology 20101124 |
| Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101 |
| In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms. | Immunology 20101001 |
| Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway. | European journal of pharmacology 20100525 |
| Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. | Molecular pharmacology 20100501 |
| Characterizing the involvement of the nuclear factor-kappa B (NF kappa B) transcription factor in uveal melanoma. | Investigative ophthalmology & visual science 20100401 |
| Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. | European journal of haematology 20100301 |
| Inhibition of IKK-beta: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32. | Bioorganic & medicinal chemistry letters 20100201 |
| Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release. | Expert opinion on investigational drugs 20100201 |
| A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour. | Journal of reproductive immunology 20100101 |
| Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. | Cancer research 20091215 |
| The effect of microenvironmental CD40 signals on TRAIL- and drug-induced apoptosis in follicular lymphoma cells. | Scandinavian journal of immunology 20091201 |
| Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Tumor necrosis factor-alpha (TNF-alpha) induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells. | Journal of pharmacological sciences 20090801 |
| Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production. | American journal of physiology. Gastrointestinal and liver physiology 20090601 |
| p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090415 |
| Novel tricyclic inhibitors of IkappaB kinase. | Journal of medicinal chemistry 20090409 |
| Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. | Molecular cancer therapeutics 20090301 |
| Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide. | International journal of molecular medicine 20081201 |
| JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. | American journal of physiology. Endocrinology and metabolism 20080501 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB. | International journal of oncology 20071201 |
| Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. | Arthritis and rheumatism 20071101 |
| The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions. | Cell cycle (Georgetown, Tex.) 20071015 |
| Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway. | Free radical biology & medicine 20070501 |
| IFN-gamma-induced upregulation of Fcgamma-receptor-I during activation of monocytic cells requires the PKR and NFkappaB pathways. | Molecular immunology 20070101 |
| Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. | Journal of immunology (Baltimore, Md. : 1950) 20060415 |
| BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060201 |
| IKK mediates ischemia-induced neuronal death. | Nature medicine 20051201 |
| Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. | The Journal of pharmacology and experimental therapeutics 20051001 |
| Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. | Journal of leukocyte biology 20050601 |
| Features of selective kinase inhibitors. | Chemistry & biology 20050601 |
| Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD. | Current opinion in investigational drugs (London, England : 2000) 20041101 |
| A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection. | Transplantation 20040415 |
| An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031201 |
| A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. | Arthritis and rheumatism 20030901 |
| BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. | The Journal of biological chemistry 20030117 |