1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
| Title | Journal |
|---|---|
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action. | Neuroscience 20121213 |
| Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. | Journal of medicinal chemistry 20121108 |
| Roles of glycogen synthase kinase 3 in Alzheimer's disease. | Current Alzheimer research 20120901 |
| Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. | Toxicology in vitro : an international journal published in association with BIBRA 20120901 |
| Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523 |
| Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. | Journal of gastroenterology 20120301 |
| Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation. | Bioorganic & medicinal chemistry letters 20120301 |
| Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities. | Journal of medicinal chemistry 20111222 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. | Bioorganic & medicinal chemistry letters 20110915 |
| Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania. | The international journal of neuropsychopharmacology 20110901 |
| Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression. | Cancer biology & therapy 20110815 |
| Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1. | Biochimie 20110701 |
| Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. | The Journal of investigative dermatology 20110701 |
| Glycogen synthase kinase-3β is a functional modulator of serotonin-1B receptors. | Molecular pharmacology 20110601 |
| The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice. | The journal of pain : official journal of the American Pain Society 20110301 |
| Glycogen synthase kinase-3β indirectly facilitates interferon-γ-induced nuclear factor-κB activation and nitric oxide biosynthesis. | Journal of cellular biochemistry 20101215 |
| Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. | Chemico-biological interactions 20101006 |
| Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. | Cellular and molecular neurobiology 20100801 |
| A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. | Proceedings of the National Academy of Sciences of the United States of America 20100622 |
| Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor. | Peptides 20100601 |
| Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells. | The American journal of pathology 20100201 |
| Cardioprotection leads to novel changes in the mitochondrial proteome. | American journal of physiology. Heart and circulatory physiology 20100101 |
| Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma. | British journal of cancer 20091215 |
| Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons. | Journal of neurovirology 20091201 |
| CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| Inhibition of endothelial progenitor cell glycogen synthase kinase-3beta results in attenuated neointima formation and enhanced re-endothelialization after arterial injury. | Cardiovascular research 20090701 |
| Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. | European journal of medicinal chemistry 20090601 |
| Exploring complex protein-ligand recognition mechanisms with coarse metadynamics. | The journal of physical chemistry. B 20090409 |
| Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress. | Biochemical pharmacology 20090315 |
| Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. | Neuropharmacology 20090201 |
| Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090201 |
| Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer. | Cancer research 20081001 |
| Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20080801 |
| Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions. | Biochemical and biophysical research communications 20080711 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells. | Neuropharmacology 20070801 |
| Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. | Experimental neurology 20070601 |
| Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. | Neuropharmacology 20070601 |
| Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060901 |
| The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders. | IDrugs : the investigational drugs journal 20060101 |
| Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies. | Bioorganic & medicinal chemistry letters 20051201 |
| Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. | Cancer research 20050315 |
| AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. | The international journal of neuropsychopharmacology 20041201 |
| GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. | Molecular psychiatry 20040501 |
| Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. | The Journal of biological chemistry 20031114 |
| Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. | Diabetes 20000201 |
| Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. | Diabetes 19990801 |
| Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. | Proceedings of the National Academy of Sciences of the United States of America 19930815 |