Pyridone 6
| Title | Journal |
|---|---|
| Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. | Nature communications 20140828 |
| Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway. | Molecules (Basel, Switzerland) 20140808 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. | Bioorganic & medicinal chemistry 20120115 |
| Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. | Journal of immunology (Baltimore, Md. : 1950) 20111101 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma. | Biochemical and biophysical research communications 20110107 |
| CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. | Arthritis research & therapy 20110101 |
| Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. | Molecular and cellular endocrinology 20100830 |
| Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. | Journal of molecular biology 20100716 |
| Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3. | Experimental cell research 20100401 |
| STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields. | International journal of radiation biology 20100101 |
| Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. | Journal of molecular biology 20090320 |
| Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. | Biological & pharmaceutical bulletin 20090101 |
| Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach. | Journal of medicinal chemistry 20081113 |
| Chemotherapy-induced toxic erythema under treatment with pegylated liposomal doxorubicin: No restriction to palms and soles. | Journal of the American Academy of Dermatology 20080201 |
| Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells. | BMC cancer 20080101 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. | Bioorganic & medicinal chemistry letters 20071215 |
| Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. | Cancer research 20061001 |
| IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling. | Respiratory research 20060101 |
| Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway. | Molecular pharmacology 20040801 |
| Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. | Bioorganic & medicinal chemistry letters 20020422 |