The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells.

Journal of neuroimmunology 20121115

A pharmacokinetic, pharmacodynamic, and electrocardiographic study of liposomal mifamurtide (L-MTP-PE) in healthy adult volunteers.

European journal of clinical pharmacology 20121001

Respiratory syncytial virus infection augments NOD2 signaling in an IFN-β-dependent manner in human primary cells.

European journal of immunology 20121001

Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses.

Molecular immunology 20121001

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

Immunity 20120824

The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment.

Journal of the American Chemical Society 20120822

Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides.

Journal of medicinal chemistry 20120726

Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

The Journal of biological chemistry 20120629

Inhibition of LiCl-induced conditioning of anticipatory nausea in rats following immune system stimulation: comparing the immunogens lipopolysaccharide, muramyl dipeptide, and polyinosinic: polycytidylic acid.

Physiology & behavior 20120515

Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.

Inflammatory bowel diseases 20120501

NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells.

International journal of molecular medicine 20120401

MDP up-regulates the gene expression of type I interferons in human aortic endothelial cells.

Molecules (Basel, Switzerland) 20120323

Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in mice.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120312

Cationic nanoglycolipidic particles as vector and adjuvant for the study of the immunogenicity of SIV Nef protein.

International journal of pharmaceutics 20120214

Lead Diversification 2: application to P38, gMTP and lead compounds.

Bioorganic & medicinal chemistry letters 20120115

Synthesis and biological evaluation of biotinyl hydrazone derivatives of muramyl peptides.

Chemical biology & drug design 20120101

Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R.

Toxicological sciences : an official journal of the Society of Toxicology 20120101

MIP-3α expression in macrophages is NOD dependent.

Digestion 20120101

New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity.

Pharmacological reports : PR 20120101

Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection.

PloS one 20120101

Retinal astrocytes pretreated with NOD2 and TLR2 ligands activate uveitogenic T cells.

PloS one 20120101

Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide.

Cellular immunology 20120101

NOD2 and CD.

Inflammatory bowel diseases 20111201

Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells.

Cytokine 20111201

Enhancement of muramyldipeptide (MDP) immunostimulatory activity by controlled multimerization on dendrimers.

Macromolecular bioscience 20111110

NOD-like receptors and RIG-I-like receptors in human eosinophils: activation by NOD1 and NOD2 agonists.

Immunology 20111101

Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice.

International immunopharmacology 20111001

Effects of bacterial products on enterocyte-macrophage interactions in vitro.

Biochemical and biophysical research communications 20110923

Multiligand specificity of pathogen-associated molecular pattern-binding site in peptidoglycan recognition protein.

The Journal of biological chemistry 20110909

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2.

Gut 20110901

Preparation and identification of a novel immunomodulator composed of muramyl dipeptide and anti-CD10 monoclonal antibody for treatment of minimal residual disease in acute leukemia children.

International immunopharmacology 20110901

Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs.

European journal of medicinal chemistry 20110901

Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species.

The FEBS journal 20110901

Elevated MDP activity in the spleen due to fungal infection.

Clinical nuclear medicine 20110901

Single high-dose treatment with glucosaminyl-muramyl dipeptide is ineffective in treating ankylosing spondylitis.

Rheumatology international 20110801

Functional expression of NOD2 in freshly isolated human peripheral blood γδ T cells.

Scandinavian journal of immunology 20110801

[Correction of the immune disorders in patients with diabetes mellitus type II with complicated diabetic foot syndrome].

Klinichna khirurhiia 20110801

Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.

The Journal of biological chemistry 20110729

New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV).

Bioorganic & medicinal chemistry letters 20110715

[Effects of muramyl dipeptide on the differentiation of human dental pulp cells].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20110701

Muramyl Dipeptide modulates differentiation, maturity of dendritic cells and anti-tumor effect of DC-mediated T cell in acute leukemia children.

Human vaccines 20110601

Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity.

Bioorganic & medicinal chemistry letters 20110601

Body temperature responses of Pekin ducks (Anas platyrhynchos domesticus) exposed to different pathogens.

Poultry science 20110601

A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-β synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth.

Journal of dermatological science 20110501

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands.

European journal of immunology 20110501

Conjugate (MTC-220) of muramyl dipeptide analogue and paclitaxel prevents both tumor growth and metastasis in mice.

Journal of medicinal chemistry 20110428

Effect of neurotrophic factor, MDP, on rats' nerve regeneration.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110401

Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers.

Journal of immunology (Baltimore, Md. : 1950) 20110401

Mifamurtide: osteosarcoma: ineffective and harmful.

Prescrire international 20110401

Muramyl dipeptide induces Th17 polarization through activation of endothelial cells.

Journal of immunology (Baltimore, Md. : 1950) 20110315

Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).

Innate immunity 20110201

Analgesic effects of chemically synthesized NOD1 and NOD2 agonists in mice.

Innate immunity 20110201

Mifamurtide for the treatment of nonmetastatic osteosarcoma.

Expert opinion on pharmacotherapy 20110201

MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity.

Vaccine 20110110

Multiple caspases mediate acute renal cell apoptosis induced by bacterial cell wall components.

Renal failure 20110101

[Evaluation of the efficiency and reactogenicity of emulsion-based adjuvant systems in the manufacture of polyclonal enteroviral diagnostic sera].

Voprosy virusologii 20110101

Recent developments in the synthesis and biological activity of muramylpeptides.

Current medicinal chemistry 20110101

Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production.

PloS one 20110101

[Experience with use of immunomodulators in treatment of tonsillitis developed at the background of preimmunization by TEOVac].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Nod2 downregulates TLR2/1 mediated IL1β gene expression in mouse peritoneal macrophages.

PloS one 20110101

[Methodic approaches to treatment of the chronic generalized parodontitis in elderly and senile patients].

Advances in gerontology = Uspekhi gerontologii 20110101

[Effects of immunocorrective therapy on immunological indices in patients with chronic bacterial prostatitis].

Urologiia (Moscow, Russia : 1999) 20110101

Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells.

Journal of leukocyte biology 20101201

Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation.

The Journal of allergy and clinical immunology 20101201

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

Genes & development 20101201

Muramyl dipeptide synergizes with Staphylococcus aureus lipoteichoic acid to recruit neutrophils in the mammary gland and to stimulate mammary epithelial cells.

Clinical and vaccine immunology : CVI 20101101

Synthesis of biologically active biotinylated muramyl dipeptides.

Bioorganic & medicinal chemistry letters 20101015

Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.

Gastroenterology 20100901

Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways.

Journal of immunology (Baltimore, Md. : 1950) 20100815

Enhanced induction of a histamine-forming enzyme, histidine decarboxylase, in mice primed with NOD1 or NOD2 ligand in response to various Toll-like receptor agonists.

Innate immunity 20100801

Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients.

Inflammatory bowel diseases 20100801

Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein.

Parasitology research 20100801

Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.

Cancer science 20100801

[Effect of muramyl dipeptide on proliferation of dendritic cells derived from children acute leukemia bone marrow in vitro].

Zhongguo shi yan xue ye xue za zhi 20100801

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse.

International immunopharmacology 20100701

Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

The Journal of biological chemistry 20100625

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

The Journal of biological chemistry 20100625

Mifamurtide: a review of its use in the treatment of osteosarcoma.

Paediatric drugs 20100601

MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function.

Inflammatory bowel diseases 20100501

Mifamurtide in osteosarcoma--a practical review.

Drugs of today (Barcelona, Spain : 1998) 20100501

GMDP augments antitumor action of the CP/TNFalpha combination in vivo.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100401

Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: chemical synthesis and functional studies.

Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100401

Proinflammatory effects of muramyldipeptide on human gingival fibroblasts.

Journal of periodontal research 20100401

Structural basis of cell wall cleavage by a staphylococcal autolysin.

PLoS pathogens 20100301

Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.

The Journal of biological chemistry 20100122

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Nature medicine 20100101

Exposure of intestinal epithelial cells to UV-killed Lactobacillus GG but not Bifidobacterium breve enhances the effector immune response in vitro.

International archives of allergy and immunology 20100101

Identification of SARS-COV spike protein-derived and HLA-A2-restricted human CTL epitopes by using a new muramyl dipeptidederivative adjuvant.

International journal of immunopathology and pharmacology 20100101

[A method for the preparation of adjuvant peptide mimetics of GMDP with the use of monoclonal antibodies and combinatorial libraries of peptides in the format of phage display].

Bioorganicheskaia khimiia 20100101

[A protein interaction network and cell signaling pathways activated by muramyl peptides].

Bioorganicheskaia khimiia 20100101

Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide.

International immunopharmacology 20091201

NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.

Journal of immunology (Baltimore, Md. : 1950) 20091201

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group.

Cancer 20091115

MDP-Induced selective tolerance to TLR4 ligands: impairment in NOD2 mutant Crohn's disease patients.

Inflammatory bowel diseases 20091101

MAIL regulates human monocyte IL-6 production.

Journal of immunology (Baltimore, Md. : 1950) 20091015

NOD2 receptors in adenopituitary folliculostellate cells: expression and function.

The Journal of endocrinology 20091001

Effect of cycloalkyl glycosides of muramyl dipeptide on antibacterial resistance of mice and cytokine production by human mononuclear cells.

Bulletin of experimental biology and medicine 20091001

Well-defined and potent liposomal hepatitis B vaccines adjuvanted with lipophilic MDP derivatives.

Nanomedicine : nanotechnology, biology, and medicine 20090901

pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling.

The Journal of biological chemistry 20090828

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Current biology : CB 20090811

Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide.

The Journal of experimental medicine 20090803

Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma.

Expert review of anticancer therapy 20090801

Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.

Journal of dental research 20090801

The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses.

The Journal of biological chemistry 20090717

Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1.

Cardiovascular research 20090715

NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.

PLoS pathogens 20090701

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Immunity 20090619

NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation.

Journal of leukocyte biology 20090601

Modulation of muramyl dipeptide stimulation of cytokine production by blood components.

Clinical and experimental immunology 20090601

Expression of nucleotide-binding oligomerization domain 2 in normal human dental pulp cells and dental pulp tissues.

Journal of endodontics 20090601

Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide.

Research in veterinary science 20090401

Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma.

Investigative ophthalmology & visual science 20090401

Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.

Journal of immunology (Baltimore, Md. : 1950) 20090401

Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways.

Clinical and experimental immunology 20090301

Screening for potential adjuvants administered by the pulmonary route for tuberculosis vaccines.

The AAPS journal 20090301

Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.

Clinical immunology (Orlando, Fla.) 20090201

The CBD1 peptide corresponding to the caveolin-1 binding domain of HIV-1 glycoprotein gp41 elicits neutralizing antibodies in cynomolgus macaques when administered with the tetanus T helper epitope.

Molecular immunology 20090201

Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts.

Arthritis and rheumatism 20090201

Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis.

Vaccine 20090114

Effect of muramyl peptides on mitochondrial respiration.

Clinical and experimental immunology 20090101

The distinct response of gammadelta T cells to the Nod2 agonist muramyl dipeptide.

Cellular immunology 20090101

[Complex treatment of acute hematogenous osteomyelitis in children].

Khirurgiia 20090101

Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants.

PloS one 20090101

[Influence of liposomal glucosaminyl-muramyl dipeptide on superoxide and nitric oxide production by murine macrophages].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101

Nod2-dependent Th2 polarization of antigen-specific immunity.

Journal of immunology (Baltimore, Md. : 1950) 20081201

NOD2 engagement induces proinflammatory cytokine production, but not apoptosis, in leukocytes isolated from patients with Crohn's disease.

European cytokine network 20081201

A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments.

Cell 20081031

Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2.

Vaccine 20081029

Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival.

World journal of gastroenterology 20081014

Common NOD2 mutations are rare in patients with inverse acne.

Journal of dermatological science 20081001

Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.

Journal of immunology (Baltimore, Md. : 1950) 20080915

Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole.

Parasitology research 20080901

Muramyldipeptide modulates CXCL-8 release of BEAS-2B cells via NOD2.

Scandinavian journal of immunology 20080901

Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain.

Bulletin of experimental biology and medicine 20080901

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes.

Inflammatory bowel diseases 20080801

Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency.

Pediatric research 20080801

Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.

Journal of leukocyte biology 20080801

PEPped up: induction of Candida albicans virulence by bacterial cell wall fragments.

Cell host & microbe 20080717

Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.

Cell host & microbe 20080717

Chemical conjugation of muramyl dipeptide and paclitaxel to explore the combination of immunotherapy and chemotherapy for cancer.

Glycoconjugate journal 20080701

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.

Proceedings of the National Academy of Sciences of the United States of America 20080603

Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1.

Immunology 20080601

Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cells.

Journal of leukocyte biology 20080601

The role of RIP2 in p38 MAPK activation in the stressed heart.

The Journal of biological chemistry 20080502

Biological activity of anomeric pairs of lipophilic glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine.

Bulletin of experimental biology and medicine 20080501

The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype.

Genes and immunity 20080401

NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.

Investigative ophthalmology & visual science 20080401

Clinical and histopathological evaluation of MDP/collagen induced arthritis rat model (MCIA) after treatment with Urtica dioica, plantago major and Hypericum perforatum L herbal mixture.

Experimental animals 20080401

Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.

Journal of immunology (Baltimore, Md. : 1950) 20080315

Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide.

Journal of immunology (Baltimore, Md. : 1950) 20080315

Muramyl dipeptide enhances the response to endotoxin to cause multiple organ injury in the anesthetized rat.

Shock (Augusta, Ga.) 20080301

NOD2: a potential target for regulating liver injury.

Laboratory investigation; a journal of technical methods and pathology 20080301

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.

Immunity 20080301

Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells.

Inflammatory bowel diseases 20080201

Inhibition of apoptosis, activation of NKT cell and upregulation of CD40 and CD40L mediated by M. leprae antigen(s) combined with Murabutide and Trat peptide in leprosy patients.

Molecular and cellular biochemistry 20080201

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

The Journal of clinical investigation 20080201

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.

Immunity 20080201

Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases.

Expert review of anticancer therapy 20080201

TAK1 is a central mediator of NOD2 signaling in epidermal cells.

The Journal of biological chemistry 20080104

Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways.

Cellular microbiology 20080101

Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta.

European journal of immunology 20080101

Mifamurtide: CGP 19835, CGP 19835A, L-MTP-PE, liposomal MTP-PE, MLV 19835A, MTP-PE, muramyltripeptide phosphatidylethanolamine.

Drugs in R&D 20080101

[Dialkylmethyl beta-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine: synthesis and infection protective and cytotoxic activities].

Bioorganicheskaia khimiia 20080101

Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells.

Respiratory research 20080101

Uveitis secondary to bacterial products.

Ophthalmic research 20080101

[Synthesis and biological activity of aryl S-beta-glycosides of 1-thio-N-acetylmuramyl-L-alanyl-D-isoglutamine].

Bioorganicheskaia khimiia 20080101

Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria.

Microbes and infection 20080101

[Adverse immunologic effects of immunomodulators revealed in experiment and ways to their surmounting].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20080101

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

The Journal of biological chemistry 20071214

Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's disease.

World journal of gastroenterology 20071214

TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase.

FEBS letters 20071127

NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction.

Gastroenterology 20071101

Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease.

Gastroenterology 20071101

A NOD to the Dodgers.

Gastroenterology 20071101

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.

Immunity 20071001

Liposomal delivery of Mycobacterium leprae antigen(s) with murabutide and Trat peptide inhibits Fas-mediated apoptosis of peripheral blood mononuclear cells derived from leprosy patients.

Indian journal of biochemistry & biophysics 20071001

Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.

European journal of immunology 20070901

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

Journal of leukocyte biology 20070701

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.

The Biochemical journal 20070601

In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models.

Clinical immunology (Orlando, Fla.) 20070601

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease.

International journal of immunogenetics 20070601

Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial.

Vaccine 20070522

The NOD2-RICK complex signals from the plasma membrane.

The Journal of biological chemistry 20070518

Identification of pentadecapeptide mimicking muramyl peptide.

Vaccine 20070412

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

Cell 20070406

Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of proinflammatory cytokines.

Journal of leukocyte biology 20070401

Modified skin window technique for the extended characterisation of acute inflammation in humans.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401

Growth failure after recurrent fever in young guinea pigs.

Physiology & behavior 20070316

Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo.

American journal of respiratory and critical care medicine 20070315

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.

Molecular cell 20070309

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.

Journal of immunology (Baltimore, Md. : 1950) 20070215

Glucosaminylmuramyl dipeptide potentiates the effects of tumor necrosis factor-alpha and cisplatin on transformed cells in vitro.

Bulletin of experimental biology and medicine 20070201

NOD protein expression and function in first trimester trophoblast cells.

American journal of reproductive immunology (New York, N.Y. : 1989) 20070101

Signal transduction of lipopolysaccharide-induced osteoclast differentiation.

Periodontology 2000 20070101

[Clinical laboratory substantiation of immunocorrection use in comprehensive treatment of chronic catarrhal gingivitis].

Stomatologiia 20070101

[Changes in functional activity of macrophages caused by bacterial muramylpeptides].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20070101

[Tuftsin--new analogues and properties].

Postepy biochemii 20070101

[Interferon-stimulating activity of muramoyl dipeptide glycosides].

Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20070101

Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop.

Journal of cellular physiology 20061101

Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia.

Journal of neuroimmunology 20061001

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide.

Journal of neurochemistry 20061001

Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe).

International immunopharmacology 20061001

Muramyl peptides augment cytotoxic effect of tumor necrosis factor-alpha in combination with cytotoxic drugs on tumor cells.

International immunopharmacology 20060901

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients.

Critical care medicine 20060901

Impaired innate immunity in Crohn's disease.

Trends in molecular medicine 20060901

Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.

Inflammatory bowel diseases 20060701

Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.

European journal of immunology 20060601

Liposomal muramyl tripeptide phosphatidyl ethanolamine: ifosfamide-containing chemotherapy in osteosarcoma.

Future oncology (London, England) 20060601

IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2.

Journal of immunology (Baltimore, Md. : 1950) 20060415

Liposomal preparations of muramyl glycopeptides as immunomodulators and adjuvants.

Vaccine 20060412

Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation.

Journal of leukocyte biology 20060401

Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide.

Microvascular research 20060301

Liposomal muramyl tripeptide phosphatidylethanolamine: Targeting and activating macrophages for adjuvant treatment of osteosarcoma.

Current cancer drug targets 20060301

Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A.

Vaccine 20060220

[Bone destruction caused by osteoclasts].

Clinical calcium 20060201

Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.

The Journal of biological chemistry 20060127

Synthesis of peptidoglycan fragments and evaluation of their biological activity.

Organic & biomolecular chemistry 20060121

MDP and other muropeptides--direct and synergistic effects on the immune system.

Journal of endotoxin research 20060101

Intracameral toxicity of bacterial components muramyl dipeptide and staurosporine: ciliary cyst formation, epithelial cell apoptosis and necrosis.

Cutaneous and ocular toxicology 20060101

[Synthesis and protective anti-infective action of anomeric lipophilic glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine].

Bioorganicheskaia khimiia 20060101

[Immunomodulators of microbial origin enhance cytotoxicity of human mononuclear leukocytes and reduce metastatic progression of Lewis lung carcinoma in mice].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20060101

[Use of licopid and viferon in the course of radiotherapy for endometrial carcinoma].

Voprosy onkologii 20060101

[Systemic autoantibodies and their correction in patients with diabetic retinopathy in type 1 diabetes mellitus].

Vestnik oftalmologii 20060101

The biological activity of new tuftsin derivatives--induction of phagocytosis.

Acta poloniae pharmaceutica 20060101

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.

The Journal of biological chemistry 20051202

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells.

Infection and immunity 20051201

Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1.

Bulletin of experimental biology and medicine 20051201

Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens.

Journal of immunology (Baltimore, Md. : 1950) 20051115

Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S.

The Journal of biological chemistry 20051104

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease.

Gut 20051101

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation.

Journal of neurochemistry 20051101

Synthesis and proinflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties.

Chembiochem : a European journal of chemical biology 20051101

TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord.

Journal of neuropathology and experimental neurology 20051101

Fever and lethargy induced by subcutaneous pyrogen infusion in unrestrained rats.

Canadian journal of physiology and pharmacology 20051101

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists.

The Journal of biological chemistry 20051028

Epigallocatechin gallate modulates cytokine production by bone marrow-derived dendritic cells stimulated with lipopolysaccharide or muramyldipeptide, or infected with Legionella pneumophila.

Experimental biology and medicine (Maywood, N.J.) 20051001

Nod2 in normal and abnormal intestinal immune function.

Gastroenterology 20051001

Effect of stable glutamine compounds on porcine islet culture.

Transplantation proceedings 20051001

Prospectively planned analysis of data from a phase III study of liposomal muramyltripeptide phosphatidylethanolamine in the treatment of osteosarcoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050910

Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis.

The Journal of biological chemistry 20050902

Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats.

Clinical and diagnostic laboratory immunology 20050901

NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype.

The Netherlands journal of medicine 20050901

Induction and localization of NOD2 protein in human endothelial cells.

Cellular immunology 20050901

Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft-versus-host reaction.

Bulletin of experimental biology and medicine 20050901

A novel immunostimulator, N-[alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen.

Journal of medicinal chemistry 20050811

Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts.

Journal of immunology (Baltimore, Md. : 1950) 20050801

Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms.

International journal of colorectal disease 20050701

Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells.

The Journal of biological chemistry 20050610

Immunomodulatory activity of analog of muramyl dipeptide and their use as adjunct to chemotherapy of Leishmania donovani in hamster.

International immunopharmacology 20050601

Innate immunity to bacterial infection: toll receptors, professional phagocytes, intra-phagosomal killing, defensins and cytoplasmic muramyl dipeptide sensors.

Current opinion in infectious diseases 20050601

Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.

Journal of immunology (Baltimore, Md. : 1950) 20050601

Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release.

Journal of immunology (Baltimore, Md. : 1950) 20050515

Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.

Cellular microbiology 20050501

Nod2 and Crohn's disease: many connected highways.

Lancet (London, England) 20050501

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

Lancet (London, England) 20050501

ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP.

The Journal of biological chemistry 20050415

Getting to the guts of NOD2.

Nature medicine 20050401

Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050320

Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation.

Vaccine 20050314

Synthesis and biological activity of tuftsin, its analogue and conjugates containing muramyl dipeptides or nor-muramyl dipeptides.

Journal of peptide science : an official publication of the European Peptide Society 20050301

Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis.

Biochimica et biophysica acta 20050214

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.

Science (New York, N.Y.) 20050204

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.

Science (New York, N.Y.) 20050204

Biological activity of conjugates of muramyl dipeptides with batracylin derivatives.

International immunopharmacology 20050201

Isolation of Waddlia malaysiensis, a novel intracellular bacterium, from fruit bat (Eonycteris spelaea).

Emerging infectious diseases 20050201

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.

Cellular microbiology 20050101

Components of the peptidoglycan-recycling pathway modulate invasion and intracellular survival of Salmonella enterica serovar Typhimurium.

Cellular microbiology 20050101

Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria.

Journal of endotoxin research 20050101

[Comparison of adjuvant activities of glucosaminyl-muramyl dipeptide and of the gene coding for granulocyte-macrophage colony-stimulating factor in DNA immunization against herpes simplex virus].

Molekuliarnaia biologiia 20050101

[Synthesis and protective activity of beta-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine with alkylalicyclic and arylaliphatic aglycons].

Bioorganicheskaia khimiia 20050101

Inflammatory diseases: is ubiquitinated NEMO at the hub?

Current biology : CB 20041229

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

Current biology : CB 20041109

Efficacy of human beta-casein fragment (54-59) and its synthetic analogue compound 89/215 against Leishmania donovani in hamsters.

Peptides 20041101

hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.

Gastroenterology 20041101

Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction.

Journal of the American College of Cardiology 20041006

Calreticulin is a binding protein for muramyl dipeptide and peptidoglycan in RK13 cells.

Biochemistry 20040921

Substrate binding affinity of Pseudomonas aeruginosa membrane-bound lytic transglycosylase B by hydrogen-deuterium exchange MALDI MS.

Biochemistry 20040907

[Human monocyte-derived multinucleated giant cells].

Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20040901

Search for potent modulators of cytokine production by macrophages.

Bulletin of experimental biology and medicine 20040901

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.

Human molecular genetics 20040815

Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia.

American journal of physiology. Regulatory, integrative and comparative physiology 20040801

[Bacteria/host interaction mediated by Nod proteins].

Nihon saikingaku zasshi. Japanese journal of bacteriology 20040801

Identification of adjuvants that enhance the therapeutic antibody response to host IgE.

Vaccine 20040729

[Chemical structures of bacterial peptidoglycan and immunomodulation in mammals].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040601

Modulation of cytokine production by some phthalimido-desmuramyl dipeptides and their cytotoxicity.

Farmaco (Societa chimica italiana : 1989) 20040501

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

The EMBO journal 20040407

Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction.

The Journal of biological chemistry 20040305

Platelet responses and anaphylaxis-like shock induced in mice by intravenous injection of whole cells of oral streptococci.

Oral microbiology and immunology 20040201

Differentially expressed genes in HIV-1-infected macrophages following treatment with the virus-suppressive immunomodulator murabutide.

Virus research 20040101

Expression of costimulatory molecules (CD80, CD86, CD28, CD152), accessory molecules (TCR alphabeta, TCR gammadelta) and T cell lineage molecules (CD4+, CD8+) in PBMC of leprosy patients using Mycobacterium leprae antigen (MLCWA) with murabutide and T cell peptide of Trat protein.

International immunopharmacology 20040101

The activity of milk leukocytes in response to a water-soluble fraction of Mycobacterium phlei in bovine subclinical mastitis.

Veterinary research communications 20040101

[Changes of the immune status of children with relapsing herpetic stomatitis, suffering from allergic diseases, during licopide treatment].

Stomatologiia 20040101

[New acellular pertussis vaccine, containing glucosaminylmuramyldipeptide].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20040101

[Activation of Langat virus infection in mice under the influence of Licopid].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20040101

A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.

The Journal of general virology 20031201

Reversal of T cell anergy in leprosy patients: in vitro presentation with Mycobacterium leprae antigens using murabutide and Trat peptide in liposomal delivery.

International immunopharmacology 20031101

Experimental study of the pathogenesis of moyamoya disease: histological changes in the arterial wall caused by immunological reactions in monkeys.

Acta medica Okayama 20031001

Systemic and ocular antibody responses to inactivated acute hemorrhagic conjunctivitis (AHC) virus; enterovirus 70 (EV70).

Ocular immunology and inflammation 20030901

Synthetic vaccines: the role of adjuvants in immune targeting.

Current medicinal chemistry 20030801

Modified glycopeptides related to cell wall peptidoglycan: conformational studies by NMR and molecular modelling.

Bioorganic & medicinal chemistry 20030717

Intracellular debugging.

Nature immunology 20030701

Pharmacokinetics and feeding responses to muramyl dipeptide in rats.

Physiology & behavior 20030701

Clinical and immunological effects of a 6 week immunotherapy cycle with murabutide in HIV-1 patients with unsuccessful long-term antiretroviral treatment.

The Journal of antimicrobial chemotherapy 20030601

A phase I study of a six-week cycle of immunotherapy with Murabutide in HIV-1 patients naive to antiretrovirals.

Medical science monitor : international medical journal of experimental and clinical research 20030601

Determination of cytotoxic activity of adamantyl-desmuramyl dipeptides.

Die Pharmazie 20030601

Attempt to establish an experimental animal model of moyamoya disease using immuno-embolic material--histological changes of the arterial wall resulting from immunological reaction in cats.

Acta medica Okayama 20030601

Stimulation of mouse resistance to bacterial infection with muramyl dipeptide glycoside.

Bulletin of experimental biology and medicine 20030501

A spin labelling study of immunomodulating peptidoglycan monomer and adamantyltripeptides entrapped into liposomes.

Biochimica et biophysica acta 20030401

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

The Journal of biological chemistry 20030314

Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives.

Journal of medicinal chemistry 20030313

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.

The Journal of biological chemistry 20030221

Adjuvant activity of peptidoglycan monomer and its metabolic products.

Vaccine 20030214

Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell-surface components through the CD14/Toll-like receptor system.

Oral microbiology and immunology 20030201

Synthesis and antitumor activity of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives.

Journal of medicinal chemistry 20030102

Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats.

Pharmacology, biochemistry, and behavior 20030101

Non-specific immunotherapy of HIV-1 infection: potential use of the synthetic immunodulator murabutide.

The Journal of antimicrobial chemotherapy 20030101

[N-acetylmuramyl-L-alanyl-D-isoglutamine glycosides. Effect of glycoside center configuration and aglycone nature on biological activity].

Bioorganicheskaia khimiia 20030101

Administration of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and diclofenac in the combination attenuates their anti-tumor activities.

Neoplasma 20030101

Autologous adjuvant linked fibroblasts induce anti-glioma immunity: implications for development of a glioma vaccine.

Journal of neuro-oncology 20030101

[Experience in the use of immunomodulator likopid in ulcer disease].

Klinicheskaia meditsina 20030101

Immune boosters. Murabutide--debut of a new immune booster?

TreatmentUpdate 20030101

Effects of hyperthermia and muramyl dipeptide on IL-1beta, IL-6, and mortality in a neonatal rat model.

Pediatric research 20021201

The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan.

The Journal of biological chemistry 20021018

Response of peripheral blood mononuclear cells in hemodialyzed patients against endotoxin and muramyldipeptide.

International journal of molecular medicine 20021001

Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide.

Journal of cell science 20020915

Effect of configuration of muramyl dipeptide glycoside bond and structure of glycoside aglycon on their capacity to stimulate production of interleukin-1 and tumor necrosis factor by macrophages.

Bulletin of experimental biology and medicine 20020901

Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.

Journal of medical microbiology 20020801

Effects of muramyl dipeptide glycosides on lymphocyte proliferation and production of interleukin-2.

Bulletin of experimental biology and medicine 20020801

Effects of nitric oxide synthase inhibitors on the febrile response to muramyl dipeptide and lipopolysaccharide in rats.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020701

Clinical tolerance and immunologic effects after single or repeated administrations of the synthetic immunomodulator murabutide in HIV-1-infected patients.

Journal of acquired immune deficiency syndromes (1999) 20020701

Stereo-isomer specific induction of renal cell apoptosis by synthetic muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine).

Molecular and cellular biochemistry 20020701

The transcriptional response of human macrophages to murabutide reflects a spectrum of biological effects for the synthetic immunomodulator.

Clinical and experimental immunology 20020601

Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc.

Mediators of inflammation 20020401

Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides.

Journal of reproductive immunology 20020301

Muramyl dipeptide (MDP) and 5-HT receptors. Neuroimmunomodulatory effects of MDP are probably not mediated through 5-HT4 or 5-HT1A receptors.

Immunopharmacology and immunotoxicology 20020201

[Theoretical problems of use of an immunomodulator likopid in clinical practice].

Terapevticheskii arkhiv 20020101

'Meshed-Bag Gathered-Bunch' method for solid-phase synthesis of small molecular diverse compounds.

Journal of combinatorial chemistry 20020101

[Likopid in the complex immunomodulating treatment of patients with sarcoidosis of the lung and intrathoracic lymph nodes].

Terapevticheskii arkhiv 20020101

[The use of immunomodulator likopid in the combined treatment pulmonary tuberculosis].

Problemy tuberkuleza 20020101

Evaluation of dendritic cell immunogenicity after activation and chemical fixation: a mixed lymphocyte reaction model.

Journal of immunotherapy (Hagerstown, Md. : 1997) 20020101

Effect of liposomal muramyl tripeptide phosphatidylethanolamine and indomethacin on hematopoietic recovery in irradiated mice.

Physiological research 20020101

Enhancement of endotoxin activity by muramyldipeptide.

Journal of endotoxin research 20020101

Muramyl dipeptide-Lys stimulates the function of human dendritic cells.

Journal of leukocyte biology 20011101

Novel adjuvant systems.

Current drug targets. Infectious disorders 20011101

Synthesis and antitumor activity of conjugates of muramyldipeptide, normuramyldipeptide, and desmuramylpeptides with acridine/acridone derivatives.

Journal of medicinal chemistry 20011025

Interleukin-18 promotes sleep in rabbits and rats.

American journal of physiology. Regulatory, integrative and comparative physiology 20010901

Muramyl dipeptide and mononuclear cell supernatant induce Langhans-type cells from human monocytes.

Journal of leukocyte biology 20010901

Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret).

International immunopharmacology 20010901

Prevention of experimental septic shock by pretreatment of mice with muramyl peptides.

International immunopharmacology 20010901

Clinical tolerance and profile of cytokine induction in healthy volunteers following the simultaneous administration of ifn-alpha and the synthetic immunomodulator murabutide.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20010901

Long-lasting rat growth enhancement by an immunoregulating synthetic peptide.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20010901

Synthesis and proinflammatory effects of peptidoglycan-derived neoglycopeptide polymers.

Journal of the American Chemical Society 20010822

Selective regulation of human immunodeficiency virus-infected CD4(+) lymphocytes by a synthetic immunomodulator leads to potent virus suppression in vitro and in hu-PBL-SCID mice.

Journal of virology 20010801

Enhanced maturation and functional capacity of monocyte-derived immature dendritic cells by the synthetic immunomodulator Murabutide.

Immunology 20010801

Biologic response modifiers in pediatric cancer.

Hematology/oncology clinics of North America 20010801

Role of the hepatic function in the development of the pyrogenic tolerance to muramyl dipeptide.

American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C/EBPbeta and STAT1: role of CD14 and Toll-like receptors 2 and 4.

European journal of immunology 20010701

Synthesis and modulation of cytokine production by two new adamantane substituted acyclic desmuramyldipeptide analogs.

Die Pharmazie 20010701

The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers.

Mediators of inflammation 20010601

Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme.

Die Pharmazie 20010401

The acute phase response in Japanese quail (Coturnix coturnix japonica).

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010201

New kinds of treatment.

AIDS treatment news 20010125

Induction of necrosis factor-alpha and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids.

Journal of medical microbiology 20010101

Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide.

International immunopharmacology 20010101

[Effect of synthetic muramyl dipeptide derivatives on staphylococcal infection in mice].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20010101

[Endogenous Tumor necrosis factor alpha unmasks the binding sites for N-acetylglucosaminyl-(beta1-4)-N-acetylmuramyl-alanyl-D-isoglutamine on the surface of melanoma cells].

Bioorganicheskaia khimiia 20010101

[Selective antiviral and immunomodulating therapy for herpetic keratitis].

Klinicheskaia meditsina 20010101

Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101

[Clinico-immunological effectiveness of likopid in conservative treatment of patients with chronic tonsillitis and chronic sinusitis].

Vestnik otorinolaringologii 20010101

[Use of likopid--an immunomodulator in the combined treatment of patients with endometrial adenocarcinoma].

Voprosy onkologii 20010101

[Clinical and immunologic effect of likopid in complex therapy of occupational bronchial asthma].

Meditsina truda i promyshlennaia ekologiia 20010101

Synergy between TLR2 and TLR4: a safety mechanism.

Blood cells, molecules & diseases 20010101

[Synthesis of N-acetylmuramoyl-L-alanyl-D-isoglutamine beta-aryl glycosides].

Bioorganicheskaia khimiia 20010101

[Correction of immune response using purified staphylococcal toxoid and likopid in the secondary immunodeficiency induced by Coxsackie virus B3].

Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20010101

The lipophilic muramyl peptide MTP-PE is a potent inhibitor of HIV replication in macrophages.

AIDS research and human retroviruses 19901001

Muramyl dipeptide inhibits replication of human immunodeficiency virus in vitro.

AIDS research and human retroviruses 19900301

Exacerbation of human immunodeficiency virus infection in promonocytic cells by bacterial immunomodulators.

Journal of acquired immune deficiency syndromes 19900101

Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19891201

Neuroimmune intercommunication, central opioids, and the immune response to bacterial endotoxin.

Journal of neuroscience research 19880101

The lipophilic muramyltripeptide MTP-PE, a biological response modifier, is an activator of protein kinase C.

Biochemical and biophysical research communications 19861114

The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. I. Synthesis of a novel haptenic MDP derivative cross-reactive with Bacillus Calmette Guerin and its application to enhanced induction of tumor immunity.

Cancer immunology, immunotherapy : CII 19850101

Hapten-specific T cell response to azobenzenearsonate-N-acetyl-L-tyrosine in the Lewis rat. II. Induction of helper activity demonstrated by TNP-haptenated ABA-peptide-Ficoll.

Journal of immunology (Baltimore, Md. : 1950) 19830201

Adjuvant activity of 6-amino-6-deoxy-muramyldipeptides and their acylamino derivatives on the induction of delayed hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.

Infection and immunity 19810601

Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs.

Neurochemical research 19800101