Home Other Building Blocks N-ACETYL-5-AMINOSALICYLIC ACID

N-ACETYL-5-AMINOSALICYLIC ACID

CAS No.:
51-59-2
Catalog Number:
AG00D90L
Molecular Formula:
C9H9NO4
Molecular Weight:
195.1721
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Product Description
Catalog Number:
AG00D90L
Chemical Name:
N-ACETYL-5-AMINOSALICYLIC ACID
CAS Number:
51-59-2
Molecular Formula:
C9H9NO4
Molecular Weight:
195.1721
MDL Number:
MFCD00463101
IUPAC Name:
5-acetamido-2-hydroxybenzoic acid
InChI:
InChI=1S/C9H9NO4/c1-5(11)10-6-2-3-8(12)7(4-6)9(13)14/h2-4,12H,1H3,(H,10,11)(H,13,14)
InChI Key:
GEFDRROBUCULOD-UHFFFAOYSA-N
SMILES:
CC(=O)Nc1ccc(c(c1)C(=O)O)O
EC Number:
200-107-4
UNII:
9H126Z3PF5
NSC Number:
54183
Properties
Complexity:
241  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
195.053g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
195.174g/mol
Monoisotopic Mass:
195.053g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
86.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6  
Literature
Title Journal
Absorption kinetics of 5-aminosalicylic acid in rat: influence of indomethacin-induced gastrointestinal lesions and Escherichia Coli Nissle 1917 medication. Neuro endocrinology letters 20110101
Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy. British journal of pharmacology 20100701
Development and validation of spectrophotometric methods for the estimation of mesalamine in tablet dosage forms. Journal of young pharmacists : JYP 20100101
Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study. Journal of pediatric gastroenterology and nutrition 20091101
Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. Journal of biomedicine & biotechnology 20090101
Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901
Nonadherence in inflammatory bowel disease: results of factor analysis. Inflammatory bowel diseases 20071001
Evaluation of biotransformation of sulphasalazine in the colon epithelial Caco-2 cells. Acta poloniae pharmaceutica 20041201
Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. Biological & pharmaceutical bulletin 20040901
Comparative pharmacokinetics of equimolar doses of 5-aminosalicylate administered as oral mesalamine (Asacol) and balsalazide: a randomized, single-dose, crossover study in healthy volunteers. Alimentary pharmacology & therapeutics 20040515
Synthesis, characterization and in vitro release of 5-aminosalicylic acid and 5-acetyl aminosalicylic acid of polyanhydride--P(CBFAS). European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030301
Is your patient taking the medicine? A simple assay to measure compliance with 5-aminosalicylic acid-containing compounds. Alimentary pharmacology & therapeutics 20021201
Study of the plasma pharmacokinetics and faecal excretion of the prodrug olsalazine and its metabolites after oral administration to horses. Journal of veterinary pharmacology and therapeutics 20020401
Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs. Human & experimental toxicology 20020301
Properties