Home Other Building Blocks MOTILIN (HUMAN, PORCINE)

MOTILIN (HUMAN, PORCINE)

CAS No.:
52906-92-0
Catalog Number:
AG00D88G
Molecular Formula:
C120H188N34O35S
Molecular Weight:
2699.0485
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
1 week
United States
$440
- +
5mg
95%
1 week
United States
$1707
- +
Product Description
Catalog Number:
AG00D88G
Chemical Name:
MOTILIN (HUMAN, PORCINE)
CAS Number:
52906-92-0
Molecular Formula:
C120H188N34O35S
Molecular Weight:
2699.0485
MDL Number:
MFCD00076521
IUPAC Name:
(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]-5-oxopentanoic acid
InChI:
InChI=1S/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)/t64-,65+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-,98-/m0/s1
InChI Key:
LVRVABPNVHYXRT-BQWXUCBYSA-N
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CCC(=O)N)CCCCN)CC(=O)N)CCCNC(=N)N)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)Cc1ccccc1)Cc1ccc(cc1)O)CCC(=O)O)CC(C)C)CCC(=O)N)CCCNC(=N)N)CCSC)CCC(=O)N)CCC(=O)O
UNII:
D85V250YSI
Properties
Complexity:
6010  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
22  
Defined Bond Stereocenter Count:
0
Exact Mass:
2698.373g/mol
Formal Charge:
0
Heavy Atom Count:
190  
Hydrogen Bond Acceptor Count:
41  
Hydrogen Bond Donor Count:
39  
Isotope Atom Count:
0
Molecular Weight:
2699.087g/mol
Monoisotopic Mass:
2697.37g/mol
Rotatable Bond Count:
95  
Topological Polar Surface Area:
1190A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-14  
Literature
Title Journal
The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. British journal of pharmacology 20130401
Can small non-peptide motilin agonists force a breakthrough as gastroprokinetic drugs? British journal of pharmacology 20121001
Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide Y concentrations in healthy individuals. Neuropeptides 20120601
Gastrointestinal hormone concentrations associated with gastric feeding in critically ill patients. JPEN. Journal of parenteral and enteral nutrition 20120301
A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin. Peptides 20120201
Transcription factor binding site polymorphism in the motilin gene associated with left-sided displacement of the abomasum in German Holstein cattle. PloS one 20120101
Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides. PloS one 20120101
Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew). Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201
[Long-term efficacy and safety research on functional dyspepsia treated with electroacupuncture and Zhizhu Kuanzhong capsule]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20111201
[Effects of transcutaneous electrical acupoint stimulation combined with general anesthesia on changes of gastric dynamics in controlled hypotension dogs]. Zhen ci yan jiu = Acupuncture research 20111201
Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage. American journal of physiology. Endocrinology and metabolism 20111101
The paraventricular nucleus modulates thyroidal motilin release and rat gastric motility. Journal of neuroendocrinology 20110901
Lactulose in fat-free milk, rather than increased ghrelin and motilin level, might help for solving constipation: author update. Nutrition (Burbank, Los Angeles County, Calif.) 20110601
Simotang enhances gastrointestinal motility, motilin and cholecystokinin expression in chronically stressed mice. World journal of gastroenterology 20110328
Effect of ginger on gastric motility and symptoms of functional dyspepsia. World journal of gastroenterology 20110107
Effect of ω-3 fatty acid on gastrointestinal motility after abdominal operation in rats. Mediators of inflammation 20110101
Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers. Biological & pharmaceutical bulletin 20110101
9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorganic & medicinal chemistry 20101101
Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). American journal of physiology. Regulatory, integrative and comparative physiology 20101001
Pharmacologic management of chronic constipation. Gastroenterology clinics of North America 20100901
Endogenous gastric mediators: patho-physiological role and measurements. Current protocols in toxicology 20100801
Mechanism of interdigestive migrating motor complex in conscious dogs. Journal of gastroenterology 20100501
Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats. Acta physiologica (Oxford, England) 20100501
Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum. British journal of pharmacology 20100101
Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. Journal of medicinal chemistry 20091112
[Promotility drugs use in critical care: indications and limits?]. Annales francaises d'anesthesie et de reanimation 20091101
Emerging drugs for chronic constipation. Expert opinion on emerging drugs 20090901
An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying. European journal of pharmacology 20090801
Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. Regulatory peptides 20090605
GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090601
Prokinetic drugs for feed intolerance in critical illness: current and potential therapies. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20090601
[Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20090601
Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus). The Journal of pharmacy and pharmacology 20090301
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. Journal of medicinal chemistry 20090226
An immunocytochemical study of the endocrine cells in the stomach and duodenum of Zonotrichia capensis subtorquata (Passeriformes, Emberizidae). Acta histochemica 20090101
Current treatment of nausea and vomiting associated with gastroparesis: antiemetics, prokinetics, tricyclics. Gastrointestinal endoscopy clinics of North America 20090101
Predictors of gastric myoelectrical activity in type 2 diabetes mellitus. Journal of clinical gastroenterology 20090101
Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome. Expert opinion on investigational drugs 20081101
A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis. Journal of alternative and complementary medicine (New York, N.Y.) 20080901
Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs. Pancreas 20080801
Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism. Peptides 20080401
Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. European journal of pharmacology 20080310
Mutational analysis of predicted intracellular loop domains of human motilin receptor. American journal of physiology. Gastrointestinal and liver physiology 20080201
Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. General and comparative endocrinology 20080101
Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in rhesus monkeys in vivo and in vitro. Digestive diseases and sciences 20071101
Emerging drugs for postoperative ileus. Expert opinion on emerging drugs 20071101
Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits. Journal of gastroenterology and hepatology 20071001
A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients. Burns : journal of the International Society for Burn Injuries 20070901
Distribution and electrophysiological effects of motilin in Purkinje cells. Neuroreport 20070827
[Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601
Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motility and brain-gut peptide. World journal of gastroenterology 20070421
Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070401
Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro. British journal of pharmacology 20070201
Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs. Inflammopharmacology 20070201
Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection. Langenbeck's archives of surgery 20070101
Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology 20070101
Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs. Journal of veterinary pharmacology and therapeutics 20061201
[Effects of acute hypobaric hypoxia on gastric emptying and intestinal propulsion: experiment with rats]. Zhonghua yi xue za zhi 20060912
[Clinicopharmacological study of gastrointestinal drugs from the viewpoint of postmarketing development]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060901
[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060901
[Regulative effect of leptin on gastric motility: experiment with conscious rats]. Zhonghua yi xue za zhi 20060829
Intragastric acidification inhibits motilin-induced phase III activity in humans. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20060801
Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy. European journal of endocrinology 20060701
Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man. European journal of clinical investigation 20060701
[Effects of intra-amygdaloid injection of motilin on the interdigestive migrating myoelectrical complex in rat]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060701
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity. The Journal of biological chemistry 20060505
Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones. Journal of peptide science : an official publication of the European Peptide Society 20060501
[Effect of motilin on intracellular free calcium of antral smooth muscle cells and its mechanisms]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060501
Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways. The American journal of gastroenterology 20060401
Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. Metabolism: clinical and experimental 20060301
Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans. Biological & pharmaceutical bulletin 20060101
Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects. Pharmacology 20060101
A motilin agonist, erythromycin, decreases circulating growth hormone levels in normal subjects but not in diabetic subjects. Journal of diabetes and its complications 20060101
Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population. Neuroscience research 20051201
Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon. European journal of pharmacology 20051107
Small intestinal manometry in patients with systemic sclerosis. European journal of gastroenterology & hepatology 20051101
Preproghrelin Leu72Met polymorphism in obese Korean children. Journal of pediatric endocrinology & metabolism : JPEM 20051101
Basic and clinical pharmacology of new motility promoting agents. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001
[Effects of acupuncture on the gastric motivity in patients with functional dyspepsia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20051001
Regulation of vascular reactivity by established and emerging GPCRs. Trends in pharmacological sciences 20050901
Effects of domperidone on human plasma levels of motilin, somatostatin, gastrin, adrenocorticotropic hormone and cortisol. Biological & pharmaceutical bulletin 20050901
[Distribution and role of motilin receptor in the amygdala of rats]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050901
Effect of erythromycin on gastric dysmotility and neuroendocrine peptides in rats with diabetes mellitus. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20050901
[Effects of intrahippocampal microinjection of motilin on interdigestive migrating myoelectrical complexes of rat duodenum]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801
Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog. The Journal of pharmacology and experimental therapeutics 20050601
Ecabet sodium raises plasma levels of calcitonin generelated peptide and substance P in healthy humans. The Journal of pharmacy and pharmacology 20050601
[Measurements and significance of serum gastrin, plasma motilin and serum beta-endorphin in patients with severe burns]. Zhonghua wai ke za zhi [Chinese journal of surgery] 20050601
Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. European journal of pharmacology 20050516
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes. Clinical biochemistry 20050501
Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine. Autonomic neuroscience : basic & clinical 20050331
Omeprazole raises somatostatin and motilin in human plasma. Biological & pharmaceutical bulletin 20050201
Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regulatory peptides 20050115
Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. American journal of physiology. Gastrointestinal and liver physiology 20050101
Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20050101
Effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa. World journal of gastroenterology 20041201
Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats. World journal of gastroenterology 20040901
Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Alimentary pharmacology & therapeutics 20040801
Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20040601
Discovery of a potent and novel motilin agonist. Journal of medicinal chemistry 20040325
Neuromodulation of experimental Shigella infection reduces damage to the gut mucosa. Microbes and infection 20040301
Screening of a large panel of gastrointestinal peptide plasma levels is not adapted for the evaluation of digestive damage following irradiation. Canadian journal of physiology and pharmacology 20040201
Autonomic neuropathy and gastrointestinal motility disorders in children and adolescents with type 1 diabetes mellitus. Journal of pediatric gastroenterology and nutrition 20040101
Quantitative determination of the polypeptide motilin in rat plasma by externally calibrated liquid chromatography/electrospray ionization mass spectrometry. Rapid communications in mass spectrometry : RCM 20040101
[Clinical observation on treatment of gastro-esophageal reflux with modified zhizhu pill]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040101
Effect of motilin on endogenous release of insulin in conscious dogs in the fed state. Digestive diseases and sciences 20031201
Excitatory effects of motilin in the hippocampus on gastric motility in rats. Brain research 20030912
Gastrointestinal motility disorders and gastrointestinal prokinetic therapy. The Veterinary clinics of North America. Small animal practice 20030901
[Effect of motilin on gastric smooth contraction induced by interstitial cells of Cajal]. Zhonghua yi xue za zhi 20030825
Intestinal aspects of cholesterol gallstone formation. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030701
Motilin-bicelle interactions: membrane position and translational diffusion. FEBS letters 20030619
Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20030401
[Synthetic studies of microbial natural products from microorganisms]. The Japanese journal of antibiotics 20030201
The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop? Regulatory peptides 20021231
Motilin regulates interdigestive gastric blood flow in dogs. Gastroenterology 20021101
(13)C-(1)H NMR relaxation and fluorescence anisotropy decay study of tyrosine dynamics in motilin. Biophysical journal 20021101
Atropine-induced gastric dysrhythmia is not normalized by electroacupuncture. Digestive diseases and sciences 20021101
The structure of erythromycin enol ether as a model for its activity as a motilide. Journal of medicinal chemistry 20021024
Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural reflex in conscious dogs. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20021001
A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. The Journal of clinical endocrinology and metabolism 20020801
[Effect of jianpi wenshen decoction on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020801
[The other gastrointestinal hormones in diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine 20020701
Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020701
Design and synthesis of novel tetra-peptide motilin agonists. Bioorganic & medicinal chemistry 20020601
In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020601
The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochemical and biophysical research communications 20020517
Effects of motilin on human interdigestive gastrointestinal and gallbladder motility, and involvement of 5HT3 receptors. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401
Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action. The Journal of biological chemistry 20020322
Potentiation of motilin-induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020201
Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin. Journal of medicinal chemistry 20020131
Effect of erythromycin on gastroduodenal contractile activity in developing neonates. Journal of pediatric gastroenterology and nutrition 20020101
Effects of adjustable gastric banding on altered gut neuropeptide levels in morbidly obese patients. Obesity surgery 20011201
Pressure-geometry relationship in the antroduodenal region in humans. American journal of physiology. Gastrointestinal and liver physiology 20011101
Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. The Journal of biological chemistry 20010921
Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial. Gut 20010901
Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin. Biological & pharmaceutical bulletin 20010901
Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy. European journal of gastroenterology & hepatology 20010701
The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. European journal of pharmacology 20010629
Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs. Digestive diseases and sciences 20010601
Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients. Digestive diseases and sciences 20010601
Demonstration of a functional motilin receptor in TE671 cells from human cerebellum. Brain research 20010323
Effect of duodenectomy on gastric motility and gastric hormones in dogs. Annals of surgery 20010301
Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010201
Immunohistochemical study of the distribution of endocrine cells in the gastrointestinal tract of the camel (Camelus bactrianus). European journal of morphology 20010201
Growth hormone secretagogue receptor family members and ligands. Endocrine 20010201
Design and synthesis of N-terminal cyclic motilin partial peptides: a novel pure motilin antagonist. Chemical & pharmaceutical bulletin 20010101
Effects of intraduodenal bile on interdigestive gastrointestinal and gallbladder motility in healthy subjects. Digestion 20010101
Discovery of the first non-peptide antagonist of the motilin receptor. Drug design and discovery 20010101
Gastroprokinetic effect and mechanism of SK-896, a new motilin analogue, during the interdigestive period in conscious dogs. Pharmacology 20010101
Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study. Digestion 20010101
Motilin and motilin receptors: characterization and functional significance. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20010101
An unusual metastatic motilin-secreting neuroendocrine tumour with a 20-year survival. Pathological, biochemical and motility features. Digestion 20010101
Receptor for motilin identified in the human gastrointestinal system. Science (New York, N.Y.) 19990625
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum. Clinical and experimental pharmacology & physiology 19990301
GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine. The Journal of pharmacology and experimental therapeutics 19950501
Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones. Life sciences 19940101
Properties