PRIMA-1
| Title | Journal |
|---|---|
| Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells. | International journal of cancer 20120515 |
| Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells. | PloS one 20120101 |
| Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model. | Clinics (Sao Paulo, Brazil) 20111201 |
| An inverse docking approach for identifying new potential anti-cancer targets. | Journal of molecular graphics & modelling 20110401 |
| APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells. | European journal of haematology 20110301 |
| Targeting mutant p53 protein and the tumor vasculature: an effective combination therapy for advanced breast tumors. | Breast cancer research and treatment 20110101 |
| p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. | Oral oncology 20110101 |
| E6 and E7 proteins from different beta-papillomaviruses types do not interfere in UVB-induced apoptosis of HaCaT keratinocytes. | Experimental dermatology 20110101 |
| PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells. | Biochemical and biophysical research communications 20101112 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers. | Oncotarget 20101001 |
| Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. | Oncogene 20100729 |
| The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. | Biochemical and biophysical research communications 20100521 |
| PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein. | International journal of oncology 20091101 |
| PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. | Cancer cell 20090505 |
| Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. | Endocrine-related cancer 20090301 |
| PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. | Oncogene 20081120 |
| PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells. | Journal of cellular biochemistry 20080815 |
| In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249. | Carcinogenesis 20080701 |
| A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. | Cell death and differentiation 20080401 |
| PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080301 |
| Restoration of p53 to limit tumor growth. | Current opinion in oncology 20080101 |
| PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53. | Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101 |
| Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics. | Cancer research 20071015 |
| Re-activation of the p53 pathway inhibits in vivo and in vitro growth of hormone-dependent human breast cancer cells. | International journal of oncology 20071001 |
| PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins. | Oncogene 20070215 |
| PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax. | Biochemical and biophysical research communications 20070105 |
| Expression proteomics to p53 mutation reactivation with PRIMA-1 in breast cancer cells. | Biochemical and biophysical research communications 20061027 |
| Dissecting p53-dependent apoptosis. | Cell death and differentiation 20060601 |
| Strategies for therapeutic targeting of the p53 pathway in cancer. | Cell death and differentiation 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion. | British journal of haematology 20060101 |
| Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: necrosis vs. apoptosis. | Anticancer research 20060101 |
| Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. | Molecular cancer therapeutics 20050601 |
| A new family of small molecules to probe the reactivation of mutant p53. | Journal of the American Chemical Society 20050504 |
| p53-dependent inhibition of progestin-induced VEGF expression in human breast cancer cells. | The Journal of steroid biochemistry and molecular biology 20050201 |
| Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells. | Breast cancer research : BCR 20050101 |
| Identification and structure-activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis. | Bioorganic & medicinal chemistry letters 20041115 |
| Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion. | British journal of haematology 20041101 |
| Targeting p53 by PTD-mediated transduction. | Trends in biotechnology 20040901 |
| [Tumor suppressor gene p53 and molecular targeting therapy]. | Gan to kagaku ryoho. Cancer & chemotherapy 20040901 |
| Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. | Cancer cell 20031101 |
| Small molecules that reactivate mutant p53. | European journal of cancer (Oxford, England : 1990) 20030901 |
| Restoring p53-dependent tumor suppression. | Cancer biology & therapy 20030101 |
| Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. | Carcinogenesis 20021201 |
| Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. | Nature medicine 20020301 |