Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometry.

Journal of separation science 20121001

Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration.

Journal of controlled release : official journal of the Controlled Release Society 20120928

Influence of P-glycoprotein on brucine transport at the in vitro blood-brain barrier.

European journal of pharmacology 20120905

Effects of brucine on bone metabolism in multiple myeloma.

Molecular medicine reports 20120801

Effects of brucine on vascular endothelial growth factor expression and microvessel density in a nude mouse model of bone metastasis due to breast cancer.

Chinese journal of integrative medicine 20120801

[Effect of NF-kappaB on inhibition of non-small cell lung cancer cell cyclooxygenase-2 by brucine].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

[Brucine chitosan thermosensitive hydrogel for intra-articular injection].

Yao xue xue bao = Acta pharmaceutica Sinica 20120501

The interaction of blood proteins with brucine.

Molecular biology reports 20120401

Simultaneous analysis of strychnine and brucine and their major metabolites by liquid chromatography-electrospray ion trap mass spectrometry.

Journal of analytical toxicology 20120401

Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors.

Journal of medicinal chemistry 20120308

[Determination of brucine and strychnine in rat after cutaneous administration of semen strychni niosome gel by LC-MS/MS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition.

Journal of ethnopharmacology 20120106

A new method for the simultaneous analysis of strychnine and brucine in Strychnos nux-vomica unprocessed and processed seeds using a carbon-paste electrode modified with multi-walled carbon nanotubes.

Phytochemical analysis : PCA 20120101

Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers.

Evidence-based complementary and alternative medicine : eCAM 20120101

Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.

PloS one 20120101

Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma.

International journal of nanomedicine 20120101

Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed.

Journal of pharmacy & bioallied sciences 20120101

Genetic analysis of the electrophysiological response to salicin, a bitter substance, in a polyphagous strain of the silkworm Bombyx mori.

PloS one 20120101

Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.

Journal of Ayurveda and integrative medicine 20120101

Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine.

International journal of nanomedicine 20120101

Rituals can kill - A fatal case of brucine poisoning.

The Australasian medical journal 20120101

Pharmacokinetics of brucine after intravenous and oral administration to rats.

Fitoterapia 20111201

Safety of individual medication of Ma Qian Zi (semen strychni) based upon assessment of therapeutic effects of Guo's therapy against moderate fluorosis of bone.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20111201

[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of strychnine and brucine in mice plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110915

Inhibition of human Na(v)1.5 sodium channels by strychnine and its analogs.

Biochemical pharmacology 20110815

Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line.

Life sciences 20110801

2,3-dimethoxy-10-oxostrychnidinium 2-(2,4,6-trinitroanilino)benzoate monohydrate: a 1:1 proton-transfer salt of brucine with o-picraminobenzoic acid.

Acta crystallographica. Section C, Crystal structure communications 20110801

rac-2-Amino-pyridinium cis-2-carb-oxy-cyclo-hexane-1-carboxyl-ate.

Acta crystallographica. Section E, Structure reports online 20110801

[Apoptosis-inducing effects of brucine on human chronic myeloid leukemia cell line K562].

Zhongguo shi yan xue ye xue za zhi 20110601

Fatal intoxication due to brucine.

Journal of analytical toxicology 20110501

Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo.

Yao xue xue bao = Acta pharmaceutica Sinica 20110501

[Pharmacokinetics of brucine in rats after intravenous administration of liposomes containing total alkaloids from seed of Strychnos nux-vomica].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

[Effect of brucine on metabolism of osteoblasts and osteoclasts in multiple myeloma].

Zhongguo shi yan xue ye xue za zhi 20110401

[Effect of brucine on secretion function and proliferation capability of T lymphocytes in patients with aplastic anemia].

Zhongguo shi yan xue ye xue za zhi 20110401

[Effect of phospholipid composition on pharmaceutical properties and anti-tumor activity of stealth liposomes containing brucine].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

[Determination and comparison of plasma protein binding rate of alkaloids from seed of Strychnou nux-vomica].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

HPLC determination of strychnine and brucine in rat tissues and the distribution study of processed semen strychni.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration.

International journal of nanomedicine 20110101

Standardization of sulaharan yoga: an ayurvedic tablet formulation.

Indian journal of pharmaceutical sciences 20110101

Effect of Shodhana (processing) on Kupeelu (Strychnos nux-vomica Linn.) with special reference to strychnine and brucine content.

Ayu 20110101

Simultaneous determination of six alkaloids in blood and urine using a hydrophilic interaction liquid chromatography method coupled with electrospray ionization tandem mass spectrometry.

Analytical and bioanalytical chemistry 20101001

Spectroscopic and physicochemical studies on organic crystal of brucine hydrogen maleate pentahydrate.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100915

Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae.

Molecular pharmacology 20100801

Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy.

Organic & biomolecular chemistry 20100721

Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro.

Drug development and industrial pharmacy 20100301

Death due to ingestion of nicotine-containing solution: case report and review of the literature.

Forensic science international 20100225

Rapid and sensitive determination of strychnine and brucine in human urine by capillary electrophoresis with field-amplified sample stacking.

Biomedical chromatography : BMC 20100201

Oxidative stress and mitochondrial functions in the intestinal Caco-2/15 cell line.

PloS one 20100101

Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant induced arthritic rat model.

BMC complementary and alternative medicine 20100101

Importance of media in shodhana (purification / processing) of poisonous herbal drugs.

Ancient science of life 20100101

Spectroscopic studies on the interaction between erlotinib hydrochloride and bovine serum albumin.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

[A comparative study on HPLC fingerprint of Semen Strychni and the processed].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091201

Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel.

Journal of materials science. Materials in medicine 20091001

Preparative resolution of etodolac enantiomers by preferential crystallization method.

Archives of pharmacal research 20091001

[Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901

Absolute configuration of 3,3'-diphenyl-[2,2'-binaphthalene]-1,1'-diol revisited.

The Journal of organic chemistry 20090807

A three-phase microfluidic chip for rapid sample clean-up of alkaloids from plant extracts.

Lab on a chip 20090721

Ion pairing and salt structure in organic salts through diffusion, Overhauser, DFT and X-ray methods.

Chemistry (Weinheim an der Bergstrasse, Germany) 20090713

A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure.

The Malaysian journal of pathology 20090601

Intestinal permeability of antitumor alkaloids from the processed seeds of Strychnos nux-vomica in a Caco-2 cell model.

Planta medica 20090501

Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20090220

Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line - RPMI 8226.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090201

Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells.

Molecular vision 20090101

Micelle enhanced fluorimetric and thin layer chromatography densitometric methods for the determination of (+/-) citalopram and its S-enantiomer escitalopram.

Analytical chemistry insights 20090101

Glycine and glycine receptor signalling in non-neuronal cells.

Frontiers in molecular neuroscience 20090101

Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.

BMC pharmacology 20090101

Bitopic ligands: all-in-one orthosteric and allosteric.

F1000 biology reports 20090101

[Strychnos alkaloids inhibit the proliferation of adult rat neuroprogenitor cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20081201

[Study on safety and pharmacodynamic action of transdermal liposomal brucine].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20081201

Simultaneous determination of five toxic alkaloids in body fluids by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115

[Pharmaceutical characteristics of brucine stealth liposomes].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

[Influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080901

Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC.

Journal of separation science 20080701

Supramolecular tilt chirality in crystals of steroids and alkaloids.

Chirality 20080301

A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products.

Planta medica 20080301

[Study on transdermal absorption characteristics of brucine in vitro].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

Nature chemical biology 20080101

Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.

International journal of toxicology 20080101

Preparation of liposomal brucine and its pharmaceutical/pharmacodynamic characterization.

Acta pharmacologica Sinica 20071101

The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070901

Allosteric modulation of muscarinic acetylcholine receptors.

Current neuropharmacology 20070901

Pseudopolymorphism in brucine: brucine-water (1/2), the third crystal hydrate of brucine.

Acta crystallographica. Section C, Crystal structure communications 20070801

[Paharmacological mechanisms of cellular immunity of overall alkali of tongbiling for the treatment of joint destruction].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070601

Application of high performance capillary electrophoresis on toxic alkaloids analysis.

Journal of separation science 20070601

[Study on the interaction between brucine and bovine serum albumin].

Guang pu xue yu guang pu fen xi = Guang pu 20070401

Hollow fiber-based liquid-phase microextraction combined with on-line sweeping for trace analysis of Strychnos alkaloids in urine by micellar electrokinetic chromatography.

Journal of chromatography. A 20070302

Electrochemical study of brucine on an electrode modified with magnetic carbon-coated nickel nanoparticles.

Analytical and bioanalytical chemistry 20070201

Isomorphous brucinium 4-nitrobenzoate methanol solvate and brucinium 4-nitrobenzoate dihydrate.

Acta crystallographica. Section C, Crystal structure communications 20070201

Development and validation of a TLC-densitometric method for the simultaneous quantitation of strychnine and brucine from Strychnos spp. and its formulations.

Journal of chromatographic science 20070101

The effect of nifedipine on oral contraceptive-induced hypertension in rats.

The Nigerian postgraduate medical journal 20061201

Diffusion coefficient distribution from NMR-DOSY experiments using Hopfield neural network.

Journal of magnetic resonance (San Diego, Calif. : 1997) 20060901

Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.

Molecular pharmacology 20060801

Brucinium 3,5-dinitrobenzoate methanol solvate, methanol disolvate and trihydrate.

Acta crystallographica. Section C, Crystal structure communications 20060801

Analysis of Strychnos alkaloids in traditional Chinese medicines with improved sensitivity by sweeping micellar electrokinetic chromatography.

Analytica chimica acta 20060721

The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism.

Journal of ethnopharmacology 20060630

Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors.

European journal of pharmacology 20060606

Brucine salts of L-alpha-hydroxy acids: brucinium hydrogen (S)-malate pentahydrate and anhydrous brucinium hydrogen (2R,3R)-tartrate at 130 K.

Acta crystallographica. Section C, Crystal structure communications 20060601

Separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation by nonaqueous capillary electrophoresis.

Journal of pharmaceutical and biomedical analysis 20060503

Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.

Molecular pharmacology 20060501

The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway.

Toxicological sciences : an official journal of the Society of Toxicology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Two pseudopolymorphic hydrates of brucine: brucine-water (1/4) and brucine-water (1/5.25) at 130 K.

Acta crystallographica. Section C, Crystal structure communications 20060401

[Studies on quality control methods of nuxvomica].

Guang pu xue yu guang pu fen xi = Guang pu 20060201

Rapid separation of strychnine and brucine on a dynamically modified poly(dimethylsiloxane) microchip followed by electrochemical detection.

Analytical and bioanalytical chemistry 20060101

Analysis of strychnos alkaloids using electrospray ionization Fourier transform ion cyclotron resonance multi-stage tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM 20060101

Determinants of positive cooperativity between strychnine-like allosteric modulators and N-methylscopolamine at muscarinic receptors.

Journal of molecular neuroscience : MN 20060101

Hydrogen bonding in brucinium dihydrogen citrate trihydrate at 130 K.

Acta crystallographica. Section C, Crystal structure communications 20051101

Physicochemical characterization of the Strychnos alkaloids by capillary zone electrophoresis.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051101

Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay.

European journal of pharmacology 20051003

Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators.

The Journal of pharmacology and experimental therapeutics 20050501

Cyclic water pentamers in triclinic crystals of brucinium L-glycerate.

Acta crystallographica. Section C, Crystal structure communications 20050201

[Concentration and determination of strychnine alkaloid in biological fluids].

Fa yi xue za zhi 20050201

New PVC nitrate-selective electrode: application to vegetables and mineral waters.

Journal of agricultural and food chemistry 20050126

Spectrophotometric determination of urinary iodine by the Sandell-Kolthoff reaction subsequent to dry alkaline ashing. Results from the Czech Republic in the period 1994-2002.

Clinical chemistry and laboratory medicine 20050101

Resolution of (+/-)-ibuprofen using (-)-brucine as a chiral selector by thin layer chromatography.

Biomedical chromatography : BMC 20041201

Direct determination of brucine by square wave voltammetry on 4-amino-2-mercaptopyrimidine self-assembled monolayer gold electrode.

Bioelectrochemistry (Amsterdam, Netherlands) 20041201

Brucine and two solvates.

Acta crystallographica. Section C, Crystal structure communications 20041201

Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor.

Journal of medicinal chemistry 20040812

Analysis of strychnine from detoxified Strychnos nux-vomica [corrected] seeds using liquid chromatography-electrospray mass spectrometry.

Journal of ethnopharmacology 20040701

Optimized and validated spectrophotometric methods for the determination of nicorandil in drug formulations and biological fluids.

Farmaco (Societa chimica italiana : 1989) 20040701

Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1H nuclear magnetic resonance spectrometry and multivariate analysis techniques.

Phytochemistry 20040701

Transverse dephasing optimised NMR spectroscopy in solids: natural-abundance 13C correlation spectra.

Chemphyschem : a European journal of chemical physics and physical chemistry 20040621

Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay.

Biochemical pharmacology 20040501

Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

Journal of ethnopharmacology 20040401

'Receptive substances': John Newport Langley (1852-1925) and his path to a receptor theory of drug action.

Medical history 20040401

On-chip potential gradient detection with a portable capillary electrophoresis system.

Electrophoresis 20040301

Analysis of strychnine and brucine in postmortem specimens by RP-HPLC: a case report of fatal intoxication.

Journal of analytical toxicology 20040301

Quantitative analysis of strychnine and Brucine in Strychnos nux-vomica using 1H-NMR.

Planta medica 20031201

Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica.

Journal of ethnopharmacology 20031001

Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors.

Bioorganic & medicinal chemistry 20030612

Highly sensitive reaction of nitrate with brucine and 3-methyl-2-benzothiazolinone hydrazone hydrochloride for the determination of nitrate in environmental samples.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030601

[Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats].

Yao xue xue bao = Acta pharmaceutica Sinica 20030601

Capillary electrophoresis with field-enhanced stacking for rapid and sensitive determination of strychnine and brucine.

Analytical and bioanalytical chemistry 20030501

First synthesis of racemic saphenamycin and its enantiomers. investigation of biological activity.

Bioorganic & medicinal chemistry 20030306

Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice.

BMC neuroscience 20030101

[HPLC determination of strychnine and brucine in Semen Strychni and its processed products].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021201

Herbal medicine causing likely strychnine poisoning.

Human & experimental toxicology 20020801

Asymmetric carbon-carbon coupling of phenols or anilines with aryllead triacetates.

Journal of the American Chemical Society 20020515

Enantiopure spiro[3.3]heptane-2,6-dicarboxylic acid.

Enantiomer 20020101

[Increased level of nitric oxide stable metabolites in the blood of highlanders].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20020101

A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines.

The Journal of organic chemistry 20010921

Nitric oxide and chronic HCV and HIV infections.

Digestive diseases and sciences 20010501

Multiple allosteric sites on muscarinic receptors.

Life sciences 20010427

Effects of brucine, a plant alkaloid, on M(1) muscarinic receptors and alpha(1)-adrenoceptors in the rabbit vas deferens preparation.

Toxicon : official journal of the International Society on Toxinology 20010401

Interactions between allosteric modulators and 4-DAMP and other antagonists at muscarinic receptors: potential significance of the distance between the N and carboxyl C atoms in the molecules of antagonists.

Neurochemical research 20010401

Construction and evaluation of ion selective electrodes for nitrate with a summing operational amplifier. Application to tobacco analysis.

Talanta 20010105

Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.

Molecular pharmacology 19990401

Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.

Life sciences 19990101

Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies.

Molecular pharmacology 19980301

Behavioral specificity of the bitter taste gene Soa.

Physiology & behavior 19971231

Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.

Molecular pharmacology 19970701

Brucine as a potent inducer of CYP2B3, the third member of the CYP2B subfamily P450 in rats.

Biological & pharmaceutical bulletin 19960201

Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase.

The Journal of pharmacology and experimental therapeutics 19940201

Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal of natural products 19910101

Screening for new compounds with antiherpes activity.

Antiviral research 19841001