Home Other Building Blocks Ceftaroline fosamil acetate

Ceftaroline fosamil acetate

CAS No.:
400827-46-5
Catalog Number:
AG00CL5M
Molecular Formula:
C24H25N8O10PS4
Molecular Weight:
744.7367
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$125
- +
5mg
99%
1 week
United States
$348
- +
10mg
99%
1 week
United States
$557
- +
50mg
99%
1 week
United States
$2071
- +
100mg
99%
1 week
United States
$2973
- +
Product Description
Catalog Number:
AG00CL5M
Chemical Name:
Ceftaroline fosamil acetate
CAS Number:
400827-46-5
Molecular Formula:
C24H25N8O10PS4
Molecular Weight:
744.7367
MDL Number:
MFCD19443689
IUPAC Name:
(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;acetate
InChI:
InChI=1S/C22H21N8O8PS4.C2H4O2/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10;1-2(3)4/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37);1H3,(H,3,4)/b26-13-;/t14-,19-;/m1./s1
InChI Key:
UGHHNQFYEVOFIV-VRDMTWHKSA-N
SMILES:
[O-]C(=O)C.CCO/N=C(/c1nsc(n1)NP(=O)(O)O)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Sc1scc(n1)c1cc[n+](cc1)C
Properties
Complexity:
1240  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Exact Mass:
744.031g/mol
Formal Charge:
0
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
744.724g/mol
Monoisotopic Mass:
744.031g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
368A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Pharmacodynamics of ceftaroline against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection. Antimicrobial agents and chemotherapy 20130601
Summary of ceftaroline fosamil clinical trial studies and clinical safety. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120901
Early response of ceftaroline fosamic in the treatment of soft-tissue infections. Expert review of clinical pharmacology 20120901
Ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. Drugs 20120730
Ceftaroline fosamil: a cephalosporin with activity against methicillin-resistant Staphylococcus aureus. Clinical therapeutics 20120401
New drugs 2012 part I. Nursing 20120301
Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies. PloS one 20120101
Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111115
Ceftaroline (Teflaro): a new cephalosporin. The Nurse practitioner 20111101
Ceftaroline fosamil: a novel broad-spectrum cephalosporin with activity against methicillin-resistant Staphylococcus aureus. The Annals of pharmacotherapy 20111101
Ceftaroline fosamil for treatment of community-acquired pneumonia: findings from FOCUS 1 and 2 and potential role in therapy. Expert review of anti-infective therapy 20110801
Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus. The Journal of antimicrobial chemotherapy 20110401
Ceftaroline fosamil: a new broad-spectrum cephalosporin. The Journal of antimicrobial chemotherapy 20110401
FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. The Journal of antimicrobial chemotherapy 20110401
FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. The Journal of antimicrobial chemotherapy 20110401
Review of ceftaroline fosamil microbiology: integrated FOCUS studies. The Journal of antimicrobial chemotherapy 20110401
Integrated safety summary of FOCUS 1 and FOCUS 2 trials: Phase III randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with community-acquired pneumonia. The Journal of antimicrobial chemotherapy 20110401
What are the properties that make an antibiotic acceptable for therapy of community-acquired pneumonia? The Journal of antimicrobial chemotherapy 20110401
Changing needs of community-acquired bacterial pneumonia: experience with ceftaroline fosamil. Preface. The Journal of antimicrobial chemotherapy 20110401
Ceftaroline fosamil (Teflaro) - a new IV cephalosporin. The Medical letter on drugs and therapeutics 20110124
Ceftaroline fosamil: drug profile and clinical data. Future microbiology 20110101
New drugs: Ceftaroline fosamil, pegloticase, and eribulin mesylate. Journal of the American Pharmacists Association : JAPhA 20110101
[Ceftaroline fosamil, a broad spectrum cephalosporin antibiotic for the treatment of community-acquired pneumonia and complicated skin and skin structure infections]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101
Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101215
The problem of complicated skin and skin structure infections: the need for new agents. The Journal of antimicrobial chemotherapy 20101101
Pharmacodynamics of ceftaroline fosamil for complicated skin and skin structure infection: rationale for improved anti-methicillin-resistant Staphylococcus aureus activity. The Journal of antimicrobial chemotherapy 20101101
CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. The Journal of antimicrobial chemotherapy 20101101
CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. The Journal of antimicrobial chemotherapy 20101101
Integrated safety summary of CANVAS 1 and 2 trials: Phase III, randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. The Journal of antimicrobial chemotherapy 20101101
Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity. The Journal of antimicrobial chemotherapy 20101101
Evaluation of the in vivo efficacy of intramuscularly administered ceftaroline fosamil, a novel cephalosporin, against a methicillin-resistant Staphylococcus aureus strain in a rabbit endocarditis model. The Journal of antimicrobial chemotherapy 20101001
Ceftaroline fosamil: a novel broad-spectrum cephalosporin. Drugs of today (Barcelona, Spain : 1998) 20101001
Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogens. Pharmacotherapy 20100401
Stability and stabilization studies of TAK-599 (Ceftaroline Fosamil), a novel N-phosphono type prodrug of anti-methicillin resistant Staphylococcus aureus cephalosporin T-91825. Chemical & pharmaceutical bulletin 20081001
Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Current opinion in investigational drugs (London, England : 2000) 20080201
Properties