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Penbutolol

CAS No.:
38363-40-5
Catalog Number:
AG00CINQ
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00CINQ
Chemical Name:
Penbutolol
CAS Number:
38363-40-5
MDL Number:
MFCD00864578
IUPAC Name:
(2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
InChI:
InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1
InChI Key:
KQXKVJAGOJTNJS-HNNXBMFYSA-N
UNII:
78W62V43DY
Properties
Complexity:
294  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
291.22g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
291.435g/mol
Monoisotopic Mass:
291.22g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
41.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2  
Literature
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Decrease in penbutolol protein binding as a consequence of treatment with some alkylating agents. Cancer chemotherapy and pharmacology 19940101
(-)-Penbutolol as a blocker of central 5-HT1A receptor-mediated responses. European journal of pharmacology 19921103
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Decrease in penbutolol central response as a cause of changes in its serum protein binding. The Journal of pharmacy and pharmacology 19900301
Effect of oral penbutolol on renal haemodynamics of hypertensive patients with renal insufficiency. The New Zealand medical journal 19850828
A comparative study of atenolol and penbutolol in hypertensive patients. European heart journal 19830701
Single daily dose penbutolol in the treatment of hypertension: a double blind crossover comparison with propranolol. European journal of clinical pharmacology 19800601
Clinical electrophysiological properties of penbutolol: a non-selective beta-blocking agent. European journal of cardiology 19800101
The effect of clonidine and penbutolol, respectively on catecholamines in blood and urine, plasma renin activity and urinary aldosterone in hypertensive patients. Archives internationales de pharmacodynamie et de therapie 19750201
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