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Home Other Building Blocks 2'-C-Methylguanosine

2'-C-Methylguanosine

CAS No.:
374750-30-8
Catalog Number:
AG00CA2J
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00CA2J
Chemical Name:
2'-C-Methylguanosine
CAS Number:
374750-30-8
MDL Number:
MFCD13194756
IUPAC Name:
2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1H-purin-6-one
InChI:
InChI=1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1
InChI Key:
NVKAMPJSWMHVDK-GITKWUPZSA-N
EC Number:
609-435-6
Properties
Complexity:
488  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
297.107g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
297.271g/mol
Monoisotopic Mass:
297.107g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
155A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.7  
Literature
Title Journal
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents. Bioorganic & medicinal chemistry letters 20111115
Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties. Journal of medicinal chemistry 20100708
Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases. European journal of medicinal chemistry 20091001
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. Bioorganic & medicinal chemistry 20090701
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication. Bioorganic & medicinal chemistry letters 20060315
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. Journal of medicinal chemistry 20041007
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. Journal of medicinal chemistry 20040422
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. The Journal of biological chemistry 20031205
Non-HIV antivirals - a review of the recent patent literature. IDrugs : the investigational drugs journal 20020801
Properties