(7R,8S,9S,10R,13R,14S,17R)-7-Hydroxy-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
| Title | Journal |
|---|---|
| The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). | Chemico-biological interactions 20150605 |
| Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism. | Archives of toxicology 20150401 |
| Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2. | Toxicology 20130107 |
| Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20120901 |
| Dietary fish oil increases fat absorption and fecal bile acid content without altering bile acid synthesis in 20-d-old weanling rats following massive ileocecal resection. | Pediatric research 20120701 |
| Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism. | Clinical science (London, England : 1979) 20120401 |
| Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings. | Basic & clinical pharmacology & toxicology 20120301 |
| Bile Acid signaling in liver metabolism and diseases. | Journal of lipids 20120101 |
| Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. | PloS one 20120101 |
| Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans. | Digestion 20120101 |
| Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. | The American journal of gastroenterology 20111201 |
| Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19. | Journal of internal medicine 20111201 |
| New insights into bile acid malabsorption. | Current gastroenterology reports 20111001 |
| The immune system in irritable bowel syndrome. | Journal of neurogastroenterology and motility 20111001 |
| Monitoring of 7α-hydroxy-4-cholesten-3-one during therapy of cerebrotendinous xanthomatosis: a case report. | Chemistry and physics of lipids 20110901 |
| Bile acid signaling after an oral glucose tolerance test. | Chemistry and physics of lipids 20110901 |
| Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers. | Inflammatory bowel diseases 20110601 |
| An evaluation of the use of serum 7-alpha-hydroxycholestenone as a diagnostic test of bile acid malabsorption causing watery diarrhea. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20110601 |
| The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function. | Chemico-biological interactions 20110530 |
| Enteric microbiome metabolites correlate with response to simvastatin treatment. | PloS one 20110101 |
| Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus. | PloS one 20110101 |
| Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. | Gastroenterology 20101101 |
| Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015 |
| Defining primary bile acid diarrhea: making the diagnosis and recognizing the disorder. | Expert review of gastroenterology & hepatology 20101001 |
| On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase. | Journal of lipid research 20100901 |
| Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency. | The Journal of biological chemistry 20100806 |
| Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. | Biochemical and biophysical research communications 20100521 |
| The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. | American journal of physiology. Gastrointestinal and liver physiology 20100301 |
| Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201 |
| Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects. | Physiological research 20100101 |
| ESI-MS/MS quantification of 7alpha-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis. | Clinica chimica acta; international journal of clinical chemistry 20100101 |
| A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20091101 |
| Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090701 |
| Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. | Pharmacogenetics and genomics 20090601 |
| Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients. | Biochemical and biophysical research communications 20090130 |
| Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids. | Scandinavian journal of gastroenterology 20090101 |
| Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients. | Lipids in health and disease 20090101 |
| Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. | Biochemistry 20081223 |
| CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection. | Journal of lipid research 20081201 |
| Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment. | The British journal of nutrition 20081101 |
| Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients. | Steroids 20081001 |
| The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. | Biochemistry 20080812 |
| Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption. | Clinical chemistry 20080601 |
| Decreased bile acid synthesis with total parenteral nutrition. | American journal of surgery 20071101 |
| Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901 |
| Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. | European journal of clinical nutrition 20070801 |
| Age-related changes in bile acid synthesis and hepatic nuclear receptor expression. | European journal of clinical investigation 20070601 |
| On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis. | Journal of lipid research 20070501 |
| Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease. | Hepatology (Baltimore, Md.) 20070501 |
| Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS. | Journal of lipid research 20070201 |
| In silico prediction of pregnane X receptor activators by machine learning approaches. | Molecular pharmacology 20070101 |
| Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. | World journal of gastroenterology 20061221 |
| Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. | Alimentary pharmacology & therapeutics 20061201 |
| Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. | Steroids 20060501 |
| Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption. | European journal of gastroenterology & hepatology 20060401 |
| Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. | Alimentary pharmacology & therapeutics 20060401 |
| Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. | European journal of clinical investigation 20060301 |
| An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation. | Methods in molecular biology (Clifton, N.J.) 20060101 |
| Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study. | European journal of clinical nutrition 20051201 |
| Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. | Gastroenterology 20051101 |
| Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. | Biochimica et biophysica acta 20051001 |
| Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration. | Atherosclerosis 20050901 |
| Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. | Gastroenterology 20050801 |
| Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. | The American journal of cardiology 20050704 |
| High serum phytosterol levels in short bowel patients on parenteral nutrition support. | Clinical nutrition (Edinburgh, Scotland) 20050601 |
| Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. | Journal of lipid research 20050201 |
| Lipoprotein metabolism in patients with anorexia nervosa: a case-control study investigating the mechanisms leading to hypercholesterolaemia. | The British journal of nutrition 20040601 |
| Influence of rifampin on serum markers of cholesterol and bile acid synthesis in men. | International journal of clinical pharmacology and therapeutics 20040601 |
| Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians. | Gastroenterology 20040301 |
| Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans. | Arteriosclerosis, thrombosis, and vascular biology 20040201 |
| Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | Metabolism: clinical and experimental 20040101 |
| Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. | Digestion 20040101 |
| Assay method for mitochondrial sterol 27-hydroxylase with 7alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liver. | Journal of lipid research 20031201 |
| Origin of oxysterols in hepatic bile of patients with biliary infection. | The American journal of gastroenterology 20031001 |
| 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes: evidence for a role of both CYP2D25 and CYP27A1. | Biochemical and biophysical research communications 20030411 |
| Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. | Journal of lipid research 20030401 |
| Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. | Proceedings of the National Academy of Sciences of the United States of America 20030204 |
| Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver. | Biochimica et biophysica acta 20021120 |
| A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | Steroids 20020701 |
| Bowel habits and bile acid malabsorption in the months after cholecystectomy. | The American journal of gastroenterology 20020701 |
| Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol. | Endocrinology 20020501 |
| Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis. | Cancer letters 20010920 |
| Effects of treatment with deoxycholic acid and chenodeoxycholic acid on the hepatic synthesis of cholesterol and bile acids in healthy subjects. | Hepatology (Baltimore, Md.) 20010501 |
| Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20010501 |
| Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. | Journal of lipid research 20010201 |