4-HYDROXYESTRONE
| Title | Journal |
|---|---|
| Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism. | Chemical research in toxicology 20171120 |
| NRF2/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity. | The Journal of biological chemistry 20141107 |
| Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations. | Bulletin of experimental biology and medicine 20120301 |
| Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells. | Journal of Cancer 20120101 |
| Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer. | Ginekologia polska 20111201 |
| Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells. | Carcinogenesis 20110801 |
| Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells. | Life sciences 20110314 |
| Gender is a risk factor for lung cancer. | Medical hypotheses 20110301 |
| Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer? | International journal of women's health 20110101 |
| Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma. | BMC cancer 20110101 |
| Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. | PloS one 20110101 |
| Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. | Chemical research in toxicology 20100816 |
| Degradation of natural estrogen and identification of the metabolites produced by soil isolates of Rhodococcus sp. and Sphingomonas sp. | Journal of bioscience and bioengineering 20100601 |
| Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection. | Talanta 20100415 |
| The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis. | Journal of photochemistry and photobiology. B, Biology 20100121 |
| The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo. | BMC medicine 20100101 |
| Comparison of estrogens and estrogen metabolites in human breast tissue and urine. | Reproductive biology and endocrinology : RB&E 20100101 |
| Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial. | Breast cancer : basic and clinical research 20100101 |
| Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. | Breast cancer research : BCR 20090101 |
| Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells. | The Journal of steroid biochemistry and molecular biology 20080501 |
| Hydroxylated estrogen metabolites influence the proliferation of cultured human monocytes: possible role in synovial tissue hyperplasia. | Clinical and experimental rheumatology 20080101 |
| Evaluation of electrospray ionization and atmospheric pressure chemical ionization for simultaneous detection of estrone and its metabolites using high-performance liquid chromatography/tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201 |
| HPLC for stress-free screening of potential prostate cancer marker catechol estrogens in urine using a diamond-electrode electrochemical and a fluorescence detector. | Journal of separation science 20070901 |
| Effects of a catechol-O-methyltransferase inhibitor on catechol estrogen-induced cellular transformation, chromosome aberrations and apoptosis in Syrian hamster embryo cells. | International journal of cancer 20070415 |
| Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33. | The FEBS journal 20070301 |
| In vitro short-term test evaluation of catecholestrogens genotoxicity. | The Journal of steroid biochemistry and molecular biology 20070101 |
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | Journal of molecular graphics & modelling 20061101 |
| Potential biomarker for early risk assessment of prostate cancer. | The Prostate 20061001 |
| Analysis of fifteen estrogen metabolites using packed column supercritical fluid chromatography-mass spectrometry. | Analytical chemistry 20060301 |
| Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060301 |
| Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. | Cancer research 20060101 |
| Development of monoclonal antibodies to 4-hydroxyestrogen-2-N-acetylcysteine conjugates: immunoaffinity and spectroscopic studies. | Chemical research in toxicology 20051001 |
| Effects of dioxin on metabolism of estrogens in waste incinerator workers. | Archives of environmental & occupational health 20050101 |
| The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17beta-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16alpha-hydroxyestradiol, and 4-hydroxyestrone. | The Journal of endocrinology 20041001 |
| Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. | The Journal of biological chemistry 20040702 |
| Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types. | The Journal of steroid biochemistry and molecular biology 20040701 |
| Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression. | Mutation research 20040604 |
| Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver. | Archives of biochemistry and biophysics 20040601 |
| Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues. | Biochemistry 20040601 |
| Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. | Breast cancer research : BCR 20040101 |
| Spectral characterization of catechol estrogen quinone (CEQ)-derived DNA adducts and their identification in human breast tissue extract. | Chemical research in toxicology 20030901 |
| Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. | Endocrinology 20030801 |
| Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry. | Journal of the American Society for Mass Spectrometry 20030501 |
| Endogenous estradiol metabolites stimulate the in vitro proliferation of human osteoblastic cells. | International journal of clinical pharmacology and therapeutics 20030401 |
| Spectroscopic characterization of the 4-hydroxy catechol estrogen quinones-derived GSH and N-acetylated Cys conjugates. | Chemical research in toxicology 20030301 |
| Stable isotope dilution high-performance liquid chromatography-electrospray ionization mass spectrometry method for endogenous 2- and 4-hydroxyestrones in human urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125 |
| Estradiol metabolism and malignant disease. | Maturitas 20020930 |
| Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers. | The American journal of pathology 20020401 |
| Catecholestrogen sulfation: possible role in carcinogenesis. | Biochemical and biophysical research communications 20020329 |
| Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. | Chemical research in toxicology 20011201 |
| The ability of four catechol estrogens of 17beta-estradiol and estrone to induce DNA adducts in Syrian hamster embryo fibroblasts. | Carcinogenesis 20010901 |
| Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen. | Steroids 20010801 |
| In vitro generation of peroxynitrite by 2- and 4-hydroxyestrogens in the presence of nitric oxide. | Chemical research in toxicology 20010501 |
| Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro. | Chemical research in toxicology 20010101 |
| Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol. | Nutrition and cancer 20010101 |
| Involvement of genotoxic effects in the initiation of estrogen-induced cellular transformation: studies using Syrian hamster embryo cells treated with 17beta-estradiol and eight of its metabolites. | International journal of cancer 20000401 |
| UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites. | Endocrinology 19991201 |
| Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. | Archives of biochemistry and biophysics 19970815 |
| Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. | Drug metabolism and disposition: the biological fate of chemicals 19940101 |
| cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. | Biochemical and biophysical research communications 19930715 |
| Reinduction of the hypnotic effects of thiopental with NSAIDs by decreasing thiopental plasma protein binding in humans. | Acta anaesthesiologica Scandinavica 19930401 |
| Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. | The Journal of pharmacology and experimental therapeutics 19930101 |