Home Other Building Blocks Epibetulinic acid

Epibetulinic acid

CAS No.:
38736-77-5
Catalog Number:
AG00C7VE
Molecular Formula:
Molecular Weight:
Pack Size
Purity
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Product Description
Catalog Number:
AG00C7VE
Chemical Name:
Epibetulinic acid
CAS Number:
38736-77-5
IUPAC Name:
(1R,3aS,5aR,5bR,7aR,9R,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
InChI:
InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23+,24+,27-,28+,29+,30-/m0/s1
InChI Key:
QGJZLNKBHJESQX-ULZDWRHHSA-N
Properties
Complexity:
861  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
456.36g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
456.711g/mol
Monoisotopic Mass:
456.36g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
57.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8.2  
Literature
Title Journal
Synthesis and biological investigation of new carbonic anhydrase IX (CAIX) inhibitors. Chemico-biological interactions 20180325
Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells. Chemico-biological interactions 20170801
Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation. Chemico-biological interactions 20170425
In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses. Chemico-biological interactions 20160225
Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. Bioorganic & medicinal chemistry letters 20160101
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters 20150815
Combined effect of microRNA, nutraceuticals and drug on pancreatic cancer cell lines. Chemico-biological interactions 20150525
Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment. Toxicology and applied pharmacology 20140301
GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death. Cancer letters 20130201
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Food chemistry 20130115
Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L. Food chemistry 20130115
A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana. Food chemistry 20130101
Bioactive oleanane, lupane and ursane triterpene acid derivatives. Molecules (Basel, Switzerland) 20121017
Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. Molecules (Basel, Switzerland) 20121012
Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors. Journal of enzyme inhibition and medicinal chemistry 20121001
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. American journal of physiology. Gastrointestinal and liver physiology 20121001
Investigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids--Langmuir monolayer and synchrotron X-ray scattering study. Journal of colloid and interface science 20120901
Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid. Journal of ethnopharmacology 20120830
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorganic & medicinal chemistry letters 20120815
Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures. Phytotherapy research : PTR 20120801
Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Cell death and differentiation 20120801
Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma (U14) tumor-bearing mice. Die Pharmazie 20120801
Exploration of the antiplatelet activity profile of betulinic acid on human platelets. Journal of agricultural and food chemistry 20120718
Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis. Phytotherapy research : PTR 20120701
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular cancer therapeutics 20120701
Molecular dynamics simulation studies of betulinic acid with human serum albumin. Journal of molecular modeling 20120601
Orthoquinone and naphthalenone derivatives from Berrya ammonilla and their anti-inflammatory activity. Planta medica 20120601
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & medicinal chemistry 20120601
NOXA as critical mediator for drug combinations in polychemotherapy. Cell death & disease 20120601
Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells. Molecules and cells 20120531
Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512
[Chemical constituents of Dolomiaea souliei]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501
Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption. Journal of medicinal chemistry 20120412
Preliminary study of the anticancer applications of mesoporous materials functionalized with the natural product betulinic acid. ChemMedChem 20120401
Rapid separation and determination of betulinic acid from a complex matrix using combination of TLC and RP-HPLC. Pakistan journal of pharmaceutical sciences 20120401
alpha-Mangostin enhances betulinic acid cytotoxicity and inhibits cisplatin cytotoxicity on HCT 116 colorectal carcinoma cells. Molecules (Basel, Switzerland) 20120308
A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives. Natural product communications 20120301
New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorganic & medicinal chemistry letters 20120215
The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation. Chemico-biological interactions 20120205
Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells? Pflugers Archiv : European journal of physiology 20120201
[Study on absorption kinetics of betulic acid in rat's intestines]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201
The natural product betulinic acid inhibits C/EBP family transcription factors. Chembiochem : a European journal of chemical biology 20120123
Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines. Natural product research 20120101
A new fatty aldol ester from the aerial part of Mimosa invisa (Mimosaceae). Natural product research 20120101
Synthesis of bioactive 28-hydroxy-3-oxolup-20(29)-en-30-al with antileukemic activity. Journal of Asian natural products research 20120101
Triterpenes from Callicarpa integerrima Champ. Yao xue xue bao = Acta pharmaceutica Sinica 20120101
Influence of betulinic acid on lymphocyte subsets and humoral immune response in mice. Polish journal of veterinary sciences 20120101
Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas. Indian journal of pharmacology 20120101
CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant & cell physiology 20111201
First self-assembly study of betulinic acid, a renewable nano-sized, 6-6-6-6-5 pentacyclic monohydroxy triterpenic acid. Nanoscale 20111101
Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii. Journal of natural products 20111028
Efficient synthesis of lupane-type saponins via gold(I)-catalyzed glycosylation with glycosyl ortho-alkynylbenzoates as donors. Organic letters 20111021
Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009
Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. Molecular carcinogenesis 20111001
New betulinic acid derivatives as potent proteasome inhibitors. Bioorganic & medicinal chemistry letters 20111001
In vitro effect of combined hybrid molecules from vitamin E analogues and betulinic acid on macrophage activity. Bulletin of experimental biology and medicine 20111001
An amphiphilic conjugate approach toward the design and synthesis of betulinic acid-polyphenol conjugates as inhibitors of the HIV-1 gp41 fusion core formation. ChemMedChem 20110905
Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer research 20110801
[Study on the chemical constituents of Leptopus chineseis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110801
Birch bark extract as therapy for chronic hepatitis C--a pilot study. Phytomedicine : international journal of phytotherapy and phytopharmacology 20110715
Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking. Journal of molecular modeling 20110701
A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat. Antimicrobial agents and chemotherapy 20110701
Constituents of the root of Anemone tomentosa. Archives of pharmacal research 20110701
New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells. Biochimie 20110601
Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress. Nitric oxide : biology and chemistry 20110430
Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. Journal of agricultural and food chemistry 20110413
Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells. Investigational new drugs 20110401
Betulinic acid prevention of d-galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms. The Journal of pharmacy and pharmacology 20110401
Anti-angiogenic effects of betulinic acid administered in nanoemulsion formulation using chorioallantoic membrane assay. Journal of biomedical nanotechnology 20110401
Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells. British journal of pharmacology 20110301
Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. Anti-cancer drugs 20110301
Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. Toxicology 20110227
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytotherapy research : PTR 20110201
Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae). Phytotherapy research : PTR 20110201
Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells. Journal of applied microbiology 20110101
Monolayer behavior of binary systems of betulinic acid and cardiolipin: thermodynamic analyses of Langmuir monolayers and AFM study of Langmuir-Blodgett monolayers. Journal of colloid and interface science 20110101
Synthesis, encapsulation and antitumor activity of new betulin derivatives. Archiv der Pharmazie 20110101
Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia). Journal of nutritional science and vitaminology 20110101
Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. PloS one 20110101
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. BMC cancer 20110101
Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. The American journal of Chinese medicine 20110101
Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions. Radiation oncology (London, England) 20110101
Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. Pharmacological reports : PR 20110101
Betulinic acid inhibits high glucose-induced vascular smooth muscle cells proliferation and migration. Journal of cellular biochemistry 20101215
Redefining the TGR5 triterpenoid binding pocket at the C-3 position. ChemMedChem 20101203
Immunomodulatory effects of betulinic acid from the bark of white birch on mice. Journal of veterinary science 20101201
[Influence of betulinic acid on proliferation, migration, cell cycle and apoptosis of pancreatic cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101
[Advances in the study of structural modifications and biological activities of betulinic acids]. Yao xue xue bao = Acta pharmaceutica Sinica 20101101
Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids. Bioorganic & medicinal chemistry letters 20100915
Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules. Immunopharmacology and immunotoxicology 20100901
Conjugates of betulin derivatives with AZT as potent anti-HIV agents. Bioorganic & medicinal chemistry 20100901
[Betulinic acid ameliorates impairment of endothelium-dependent relaxation induced by oxidative stress in rat aorta]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100901
Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells. International immunopharmacology 20100801
Modulation of apoptosis by natural products for cancer therapy. Planta medica 20100801
Antitumor effect of betulinic acid on human acute leukemia K562 cells in vitro. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100801
Synthesis and anticancer activity of novel betulinic acid and betulin derivatives. Archiv der Pharmazie 20100801
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. International journal of cancer 20100715
Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells. Molecular and cellular biochemistry 20100701
Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma. British journal of cancer 20100629
Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. Bioorganic & medicinal chemistry 20100615
Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals. Journal of agricultural and food chemistry 20100609
Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites. DNA repair 20100604
Anti-angiogenic and cytotoxicity studies of some medicinal plants. Planta medica 20100601
Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity. Bioorganic & medicinal chemistry letters 20100601
[Studies on the triterpenoids of Vitex trifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601
Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC. Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular cancer research : MCR 20100501
In vitro anticancer studies of alpha- and beta-D-glucopyranose betulin anomers. Chemico-biological interactions 20100429
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. Journal of medicinal chemistry 20100422
Antiprotozoal activity of betulinic acid derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology 20100401
Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis. Phytotherapy research : PTR 20100301
Betulinic acid, a natural compound with potent anticancer effects. Anti-cancer drugs 20100301
Anti-leishmanial activity of betulin derivatives. The Journal of antibiotics 20100301
Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20100301
Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7. Pharmaceutical biology 20100301
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. Journal of medicinal chemistry 20100114
Synthesis of a molecularly imprinted polymer for the solid-phase extraction of betulin and betulinic acid from plane bark. Phytochemical analysis : PCA 20100101
Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. Biochemical and biophysical research communications 20100101
Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells. Acta pharmacologica Sinica 20100101
Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis. Bioscience, biotechnology, and biochemistry 20100101
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Molecular cancer 20100101
Rapid validated HPTLC method for estimation of betulinic acid in Nelumbo nucifera (Nymphaeaceae) rhizome extract. Phytochemical analysis : PCA 20100101
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. Journal of medicinal chemistry 20091210
Cellular fingerprints: a novel approach using large-scale cancer cell line data for the identification of potential anticancer agents. Chemical biology & drug design 20091101
Betulin-derived compounds as inhibitors of alphavirus replication. Journal of natural products 20091101
[Studies on the chemical constituents from the seed of Forsythia suspense]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091101
Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet. Journal of agricultural and food chemistry 20091014
Betulinic acid treatment promotes apoptosis in hepatoblastoma cells. International journal of oncology 20091001
[Effect of betulinic acid on inducing apoptosis of human multiple myeloma cell line RPMI-8226]. Zhongguo shi yan xue ye xue za zhi 20091001
Mitochondrial membrane potential disruption pattern in human sperm. Human reproduction (Oxford, England) 20090901
Targeting mitochondrial apoptosis by betulinic acid in human cancers. Drug discovery today 20090901
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity. Bioorganic & medicinal chemistry 20090901
Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. Journal of natural products 20090901
Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorganic & medicinal chemistry letters 20090815
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitology research 20090701
Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorganic & medicinal chemistry letters 20090701
A new lipid and other constituents from the rhizomes of Nelumbo nucifera. Journal of Asian natural products research 20090701
Triterpenoids from the roots of Pterospermum heterophyllum Hance. Journal of Asian natural products research 20090701
Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. Molecules (Basel, Switzerland) 20090604
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. Journal of medicinal chemistry 20090528
Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. European journal of clinical investigation 20090501
Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression. The FEBS journal 20090501
Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules (Basel, Switzerland) 20090424
Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones. Bioorganic & medicinal chemistry letters 20090415
Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana. Planta medica 20090201
Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis : an international journal on programmed cell death 20090201
Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae). Inflammopharmacology 20090201
Peltophorum africanum, a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid. The Tohoku journal of experimental medicine 20090201
Identification and isolation of pharmacologically active triterpenes in Betuale cortex, Betula pendula Roth., Betulaceae. Bosnian journal of basic medical sciences 20090201
Enhancing the divergent activities of betulinic acid via neoglycosylation. Organic letters 20090115
Betulinic acid binding to human serum albumin: a study of protein conformation and binding affinity. Journal of photochemistry and photobiology. B, Biology 20090109
Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke. Molecules (Basel, Switzerland) 20090108
Uapaca genus (Euphorbiaceae), a good source of betulinic acid. Fitoterapia 20090101
Betulinic acid: a natural product with anticancer activity. Molecular nutrition & food research 20090101
Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. Journal of natural products 20090101
Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells. Journal of translational medicine 20090101
[Drug discovery based on classic natural products]. Yao xue xue bao = Acta pharmaceutica Sinica 20090101
Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PloS one 20090101
Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells. Neoplasma 20090101
Chemical composition of the stem bark and leaves of Ficus pandurata Hance. Natural product research 20090101
Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection. Journal of pharmaceutical and biomedical analysis 20081215
Triterpene based compounds with potent anti-maturation activity against HIV-1. Bioorganic & medicinal chemistry letters 20081215
Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells. Molecular carcinogenesis 20081201
Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland. Molecular and cellular biochemistry 20081201
Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081201
Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. Journal of ethnopharmacology 20081120
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. Bioorganic & medicinal chemistry 20081101
Determination of betulinic acid from Orthosiphon stamineus leaf extract in rat plasma. Die Pharmazie 20081101
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. Pharmacology, biochemistry, and behavior 20081001
Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. The Journal of organic chemistry 20080919
Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives. Bioorganic & medicinal chemistry letters 20080915
Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. Journal of natural products 20080801
[Studies on chemical constituents from roots of Pterospermum heterophyllum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801
[Effect of betulinic acid on proliferation and apoptosis in Jurkat cells and its mechanism]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080801
Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cellular signalling 20080701
Nitric oxide induces caspase activity in boar spermatozoa. Theriogenology 20080701
Antibacterial activity of labdane diterpenoids from Stemodia foliosa. Journal of natural products 20080701
[Chemical constituents from herb of Gueldenstaedtia stenophylla]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701
A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation. Natural product research 20080615
Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents. Carbohydrate research 20080505
[RP-HPLC determination of betulinic acid in Callicarpa macrophylla]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401
Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. Investigational new drugs 20080201
Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. Chemical & pharmaceutical bulletin 20080201
[Study on triterpenes from of Ligularia xanthotricha]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1. Antimicrobial agents and chemotherapy 20080101
Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants. Journal of natural products 20080101
HA14-1 is able to reconstitute the impaired mitochondrial pathway of apoptosis in renal cell carcinoma cell lines. Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101
Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer research 20071215
Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis. Journal of ethnopharmacology 20071101
Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS letters 20071016
Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae). Journal of ethnopharmacology 20071008
Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic & clinical pharmacology & toxicology 20071001
[Chemical constituents in the root of Cynanchum auriculatum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001
Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa. Journal of ethnopharmacology 20070905
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of medicinal chemistry 20070823
Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. The Journal of pharmacology and experimental therapeutics 20070801
High-performance thin-layer chromatographic method for quantitative determination of 4alpha-methyl-24beta-ethyl-5alpha-cholesta-14,25-dien-3beta-ol, 24beta-ethylcholesta-5,9(11),22E-trien-3beta-ol, and betulinic acid in Clerodendrum inerme. Journal of separation science 20070801
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities. Molecular cancer therapeutics 20070701
The constituents from the stems of Garcinia cowa Roxb. and their cytotoxic activities. Die Pharmazie 20070701
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer letters 20070618
Triterpenoid pyrazines and benzopyrazines with cytotoxic activity. Journal of natural products 20070401
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer research 20070315
Triterpenoids from Eugenia grandis: structure elucidation by NMR spectroscopy. Magnetic resonance in chemistry : MRC 20070301
Biotransformation of betulinic and betulonic acids by fungi. Phytochemistry 20070301
Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives. Bioorganic & medicinal chemistry letters 20070301
Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC. Journal of pharmaceutical and biomedical analysis 20070219
A new multiparameter flow cytometric method for human semen analysis. Human reproduction (Oxford, England) 20070201
Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae). Phytotherapy research : PTR 20070201
[Biological activity tests of chemical constituents from two Brazilian Labiatae plants]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201
Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Planta medica 20070201
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A. Bioorganic & medicinal chemistry letters 20061215
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents. Bioorganic & medicinal chemistry 20061001
Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn-Schmiedeberg's archives of pharmacology 20061001
Triterpenic and other lipophilic components from industrial cork byproducts. Journal of agricultural and food chemistry 20060906
[Studies on triterpenoids from Potentilla chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901
Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorganic & medicinal chemistry 20060815
A new assault on HIV. Scientific American 20060601
Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion. Planta medica 20060601
Betulinic acid derivatives as anticancer agents: structure activity relationship. Anti-cancer agents in medicinal chemistry 20060501
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives. Bioorganic & medicinal chemistry 20060401
Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status. International journal of cancer 20060301
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines. Journal of natural products 20060301
Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia. Archives of pharmacal research 20060301
Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships. Journal of agricultural and food chemistry 20060208
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. Biological & pharmaceutical bulletin 20060201
Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta. Planta medica 20060201
[Studies on chemical constituents of hairy root of Cassia obtusifolia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201
Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines. International journal of cancer 20060101
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects. Medicinal research reviews 20060101
[Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives]. Bioorganicheskaia khimiia 20060101
Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS. Phytochemical analysis : PCA 20060101
Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro. Doklady. Biochemistry and biophysics 20060101
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Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene 20051020
Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes. Experimental dermatology 20051001
Phospholipid nanosomes. Current drug delivery 20051001
[Chemical constituents from the mangrove plant Ceriops tagal]. Yao xue xue bao = Acta pharmaceutica Sinica 20051001
Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. International journal of oncology 20050901
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[Mitochondrial damage in human sperm caused by the antineoplastic agent betulinic acid]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20050801
Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy. The Journal of pharmacology and experimental therapeutics 20050801
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. Journal of natural products 20050801
Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans. Archives of pharmacal research 20050801
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Lupane triterpenoids from Maytenus species. Journal of natural products 20050701
The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV. Expert opinion on investigational drugs 20050601
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & medicinal chemistry 20050516
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica. Chemistry & biodiversity 20050501
Caspase activation in human spermatozoa in response to physiological and pathological stimuli. Fertility and sterility 20050401
Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl. Toxicology letters 20050315
Sensitization for anticancer drug-induced apoptosis by betulinic Acid. Neoplasia (New York, N.Y.) 20050201
Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. The Journal of pharmacy and pharmacology 20050101
Betulinic acid derivatives as HIV-1 antivirals. Trends in molecular medicine 20050101
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Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells. Pharmacological reports : PR 20050101
Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its derivatives by semi-empirical molecular-orbital method. Anticancer research 20050101
Purification of betulinic acid from Eugenia florida (Myrtaceae) by high-speed counter-current chromatography. Phytochemical analysis : PCA 20050101
Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by alpha-DL-tocopherol. Toxicology letters 20041102
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells. Oncogene 20041007
Immobilized betulinic acid column and its interactions with phospholipase A2 and snake venom proteins. Journal of separation science 20041001
Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. European journal of pharmacology 20040913
Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives. Bioorganic & medicinal chemistry letters 20040802
Betulinic acid-induced apoptosis in leukemia cells. Leukemia 20040801
Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection. Journal of separation science 20040801
Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells. Acta neurochirurgica 20040701
Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells. Anti-cancer drugs 20040701
Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity. Journal of natural products 20040701
Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents. Bioorganic & medicinal chemistry letters 20040621
Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. Journal of agricultural and food chemistry 20040602
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala. Journal of natural products 20040601
New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. Journal of natural products 20040601
Betulinic acid and its derivatives as anti-angiogenic agents. Bioorganic & medicinal chemistry letters 20040503
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. British journal of cancer 20040419
Betulinic acid: a promising anticancer candidate. IDrugs : the investigational drugs journal 20040401
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrobial agents and chemotherapy 20040201
Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. Phytotherapy research : PTR 20040201
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues. Bioorganic & medicinal chemistry 20040102
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Medicinal research reviews 20040101
Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside. Glycoconjugate journal 20040101
Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages. Archives of pharmacal research 20031201
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[Studies on the constituents from the stems of Spatholobus suberectus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta. Journal of natural products 20031101
Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives. Bioorganic & medicinal chemistry letters 20031006
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. Journal of immunology (Baltimore, Md. : 1950) 20030915
A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents. Mini reviews in medicinal chemistry 20030901
Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells. Head & neck 20030901
Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia 20030701
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera. Journal of ethnopharmacology 20030501
A new acylglycosyl sterol from Quisqualis Fructus. Archives of pharmacal research 20030401
New ursolic and betulinic derivatives as potential cytotoxic agents. Journal of enzyme inhibition and medicinal chemistry 20030401
New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. Journal of natural products 20030301
Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytotherapy research : PTR 20030201
Constituents of antibacterial extract of Caesalpinia paraguariensis Burk. Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101
[Epimerization of hydroxyl group in the lupan series of triterpenes]. Bioorganicheskaia khimiia 20030101
[Synthesis and antiviral activity of hydrazides and substituted benzalhydrazides of betulinic acid and its derivatives]. Bioorganicheskaia khimiia 20030101
Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures. Polish journal of pharmacology 20030101
Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM 20030101
[Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives]. Bioorganicheskaia khimiia 20030101
Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Planta medica 20021201
Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. Molecular medicine (Cambridge, Mass.) 20021201
Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clinica chimica acta; international journal of clinical chemistry 20021101
Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. Journal of agricultural and food chemistry 20020925
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Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. The Biochemical journal 20020901
[Study on chemical constituents of rhizome of Anemone raddeana]. Yao xue xue bao = Acta pharmaceutica Sinica 20020901
[Studies on chemical constituents in fruit of Eucalyptus globulus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801
Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical science monitor : international medical journal of experimental and clinical research 20020701
Synthesis of combinatorial libraries based on terpenoid scaffolds. Combinatorial chemistry & high throughput screening 20020501
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. Journal of natural products 20020501
Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Japanese journal of cancer research : Gann 20020401
[Studies on flavoniod constituents of Hedysarum multijugum]. Yao xue xue bao = Acta pharmaceutica Sinica 20020301
Mitochondrial involvement in tracheary element programmed cell death. Cell death and differentiation 20020201
Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101
Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC. Phytochemical analysis : PCA 20020101
[Are mitochondria targets of anticancer drugs responsible for apoptosis?]. Annales de biologie clinique 20020101
Antimycobacterial plant terpenoids. Planta medica 20011101
Development of C-20 modified betulinic acid derivatives as antitumor agents. Bioorganic & medicinal chemistry letters 20010903
A small-molecule antagonist of virion assembly. Expert opinion on investigational drugs 20010901
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. The Journal of investigative dermatology 20010801
Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation. Antimicrobial agents and chemotherapy 20010401
Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent. Melanoma research 20010401
Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. Experimental cell research 20010115
Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564. Antimicrobial agents and chemotherapy 20010101
[Studies on chemical constituents from Buddleja lindleyana Fert]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010101
Oleanane triterpenes from Junellia tridens. Journal of natural products 20001201
Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives. Chemical & pharmaceutical bulletin 20000901
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorganic & medicinal chemistry 19971201
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer research 19971101
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. Journal of medicinal chemistry 19960301
Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action. Journal of medicinal chemistry 19960301
Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry. Journal of medicinal chemistry 19960301
Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells. Proceedings of the National Academy of Sciences of the United States of America 19940426
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. Journal of natural products 19940201
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