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mikamycin B

CAS No.:
3131-03-1
Catalog Number:
AG00C6LL
Molecular Formula:
C45H54N8O10
Molecular Weight:
866.9579
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
1 week
United States
$223
- +
5mg
95%
1 week
United States
$490
- +
10mg
95%
1 week
United States
$757
- +
25mg
95%
1 week
United States
$1473
- +
Product Description
Catalog Number:
AG00C6LL
Chemical Name:
mikamycin B
CAS Number:
3131-03-1
Molecular Formula:
C45H54N8O10
Molecular Weight:
866.9579
MDL Number:
MFCD01940050
IUPAC Name:
N-[3-[[4-(dimethylamino)phenyl]methyl]-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide
InChI:
InChI=1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)
InChI Key:
YGXCETJZBDTKRY-UHFFFAOYSA-N
SMILES:
CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(NC(=O)C2N(C(=O)C(N(C(=O)C3N(C1=O)CCC3)C)Cc1ccc(cc1)N(C)C)CCC(=O)C2)c1ccccc1
NSC Number:
92554
Properties
Complexity:
1700  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
866.396g/mol
Formal Charge:
0
Heavy Atom Count:
63  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
866.973g/mol
Monoisotopic Mass:
866.396g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
228A^2
Undefined Atom Stereocenter Count:
7  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
Characterization of MLS(b) resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types. Microbiology and immunology 20120901
Distribution, characterization and genetic bases of erythromycin resistance in staphylococci and enterococci originating from livestock. Zoonoses and public health 20120501
Comparison of BD Phoenix and bioMérieux Vitek 2 automated systems for the detection of macrolide-lincosamide-streptogramin B resistance among clinical isolates of Staphylococcus. Diagnostic microbiology and infectious disease 20120301
In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates. International journal of antimicrobial agents 20111001
PCR ribotype prevalence and molecular basis of macrolide-lincosamide-streptogramin B (MLSB) and fluoroquinolone resistance in Irish clinical Clostridium difficile isolates. The Journal of antimicrobial chemotherapy 20110901
A study on erm(B)-mediated MLS resistance in Streptococcus pyogenes clinical isolates. Diagnostic microbiology and infectious disease 20110701
Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran. Medical science monitor : international medical journal of experimental and clinical research 20110101
Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy. The Journal of antimicrobial chemotherapy 20101101
Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III-1 genetic clone family. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100901
Macrolide, lincosamide, and streptogramin B-constitutive-type resistance in Corynebacterium pseudodiphtheriticum isolated from upper respiratory tract specimens. Microbial drug resistance (Larchmont, N.Y.) 20100601
Molecular ecology of macrolide-lincosamide-streptogramin B methylases in waste lagoons and subsurface waters associated with swine production. Microbial ecology 20100401
[Investigation of macrolide-lincosamide-streptogramin B (MLS(B)) and telithromycin resistance in clinical strains of staphylococci]. Mikrobiyoloji bulteni 20100401
NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Current opinion in investigational drugs (London, England : 2000) 20100201
Prevalence of erythromycin and clindamycin resistance among clinical isolates of the Streptococcus anginosus group in Germany. Journal of medical microbiology 20090201
Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A). The Journal of antimicrobial chemotherapy 20090101
Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin. Journal of animal science 20080901
Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. International journal of antimicrobial agents 20080401
Foggy D-shaped zone of inhibition in Staphylococcus aureus owing to a dual character of both inducible and constitutive resistance to macrolide-lincosamide-streptogramin B. The Journal of antimicrobial chemotherapy 20080301
Prevalence and mechanisms of erythromycin and clindamycin resistance in clinical isolates of beta-haemolytic streptococci of Lancefield groups A, B, C and G in Seville, Spain. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080101
Macrolide-lincosamide-streptogramin B resistant phenotypes and genotypes for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006. Polish journal of microbiology 20080101
Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids. The Journal of antimicrobial chemotherapy 20070801
Structural insights into the non-additivity effects in the sequence-to-reactivity algorithm for serine peptidases and their inhibitors. Journal of molecular biology 20070323
Detection and prevalence of inducible clindamycin resistance in staphylococci. Journal of medical microbiology 20070301
Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20070301
[The correlation between phenotypes and genotypes of macrolides, lincosamides and streptogramins B resistance in Staphylococcus aureus]. Medycyna doswiadczalna i mikrobiologia 20070101
In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes. Folia microbiologica 20070101
Prevalence and association of PCR ribotypes of Clostridium difficile isolated from symptomatic patients from Warsaw with macrolide-lincosamide-streptogramin B (MLSB) type resistance. Journal of medical microbiology 20060201
Macrolide, lincosamide and streptogramin B resistance in a dominant clone of Australian community methicillin-resistant Staphylococcus aureus. The Journal of antimicrobial chemotherapy 20051101
Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. Journal of the American Chemical Society 20050706
Presence of macrolide-lincosamide-streptogramin B and tetracycline antimicrobials in swine waste treatment processes and amended soil. Water environment research : a research publication of the Water Environment Federation 20050101
Macrolide resistance phenotypes of commensal viridans group streptococci and Gemella spp. and PCR detection of resistance genes. International journal of antimicrobial agents 20040601
Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040515
The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. Journal of molecular biology 20030725
Prevalence and association of macrolide-lincosamide-streptogramin B (MLS(B)) resistance with resistance to moxifloxacin in Clostridium difficile. The Journal of antimicrobial chemotherapy 20030301
[Macrolide resistance phenotypes and genotypes in group G streptococci]. Mikrobiyoloji bulteni 20030101
Purification and biochemical characterization of the ErmSF macrolide-lincosamide-streptogramin B resistance factor protein expressed as a hexahistidine-tagged protein in Escherichia coli. Protein expression and purification 20020601
Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities. The Journal of antimicrobial chemotherapy 20020101
Analysis of macrolide-lincosamide-streptogramin B (MLS(B)) resistance determinant in strains of Clostridium difficile. Microbial drug resistance (Larchmont, N.Y.) 20020101
Streptogramin resistance among Enterococcus faecium isolated from production animals in Denmark in 1997. Microbial drug resistance (Larchmont, N.Y.) 20020101
Unusual inducible cross resistance to macrolides, lincosamides, and streptogramins B by methylase production in clinical isolates of Staphylococcus aureus. Microbial drug resistance (Larchmont, N.Y.) 20010101
Properties