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Home Other Building Blocks Agn 195183

Agn 195183

CAS No.:
367273-07-2
Catalog Number:
AG00C6KT
Molecular Formula:
C22H22ClF2NO4
Molecular Weight:
437.8642
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$473
- +
10mg
98%
1 week
United States
$682
- +
25mg
98%
1 week
United States
$1307
- +
50mg
98%
1 week
United States
$1932
- +
Product Description
Catalog Number:
AG00C6KT
Chemical Name:
Agn 195183
CAS Number:
367273-07-2
Molecular Formula:
C22H22ClF2NO4
Molecular Weight:
437.8642
MDL Number:
MFCD18633237
IUPAC Name:
4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid
InChI:
InChI=1S/C22H22ClF2NO4/c1-21(2)5-6-22(3,4)16-12(21)9-11(18(27)17(16)23)19(28)26-10-7-13(24)15(20(29)30)14(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)
InChI Key:
PNAWUIKCVQSLFG-UHFFFAOYSA-N
SMILES:
O=C(c1cc2c(c(c1O)Cl)C(C)(C)CCC2(C)C)Nc1cc(F)c(c(c1)F)C(=O)O
UNII:
RC87L028HU
Properties
Complexity:
676  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
437.121g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
437.868g/mol
Monoisotopic Mass:
437.121g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
86.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.4  
Literature
Title Journal
Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells. Transplantation 20070227
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. Journal of cellular biochemistry 20060201
Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. Journal of molecular medicine (Berlin, Germany) 20040201
Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorganic & medicinal chemistry letters 20021104
Properties