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Telatinib

CAS No.:
332012-40-5
Catalog Number:
AG00C6JY
Molecular Formula:
C20H16ClN5O3
Molecular Weight:
409.8257
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$237
- +
10mg
98%
1 week
United States
$387
- +
50mg
98%
1 week
United States
$1132
- +
100mg
98%
1 week
United States
$1857
- +
Product Description
Catalog Number:
AG00C6JY
Chemical Name:
Telatinib
CAS Number:
332012-40-5
Molecular Formula:
C20H16ClN5O3
Molecular Weight:
409.8257
MDL Number:
MFCD18251453
IUPAC Name:
4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide
InChI:
InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
InChI Key:
QFCXANHHBCGMAS-UHFFFAOYSA-N
SMILES:
CNC(=O)c1nccc(c1)COc1nnc(c2c1occ2)Nc1ccc(cc1)Cl
UNII:
18P7197Q7J
Properties
Complexity:
548  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
409.094g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
409.83g/mol
Monoisotopic Mass:
409.094g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
102A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1  
Literature
Title Journal
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters 20130801
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. Journal of medicinal chemistry 20121227
The observed correlation between in vivo clinical pharmacokinetic parameters and in vitro potency of VEGFR-2 inhibitors. Can this be used as a prospective guide for the development of novel compounds? Arzneimittel-Forschung 20120401
Phase I evaluation of telatinib, a VEGF receptor tyrosine kinase inhibitor, in combination with bevacizumab in subjects with advanced solid tumors. Annals of oncology : official journal of the European Society for Medical Oncology 20111101
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. Journal of the National Cancer Institute 20110504
Development of second-generation VEGFR tyrosine kinase inhibitors: current status. Current oncology reports 20110401
Targeted therapies for metastatic esophagogastric cancer. Current treatment options in oncology 20110301
Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors. Investigational new drugs 20110201
Common secondary causes of resistant hypertension and rational for treatment. International journal of hypertension 20110101
Vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers. Cardiology research and practice 20110101
Phase I study of telatinib (BAY 57-9352): analysis of safety, pharmacokinetics, tumor efficacy, and biomarkers in patients with colorectal cancer. Vascular cell 20110101
Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors. European journal of medicinal chemistry 20101101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20100901
A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080. Journal of pharmacokinetics and pharmacodynamics 20100801
Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Journal of the National Cancer Institute 20100505
Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20100401
Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090901
Phase I dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours. British journal of cancer 20081104
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20081001
Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research 20080601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20070601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20070101
Properties