Home Other Building Blocks DOV 21947 hydrochloride

DOV 21947 hydrochloride

CAS No.:
410074-74-7
Catalog Number:
AG00C6IM
Molecular Formula:
C11H12Cl3N
Molecular Weight:
264.5787
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$543
- +
10mg
99%
1 week
United States
$890
- +
50mg
99%
1 week
United States
$2557
- +
Product Description
Catalog Number:
AG00C6IM
Chemical Name:
DOV 21947 hydrochloride
CAS Number:
410074-74-7
Molecular Formula:
C11H12Cl3N
Molecular Weight:
264.5787
MDL Number:
MFCD26405807
IUPAC Name:
(1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane;hydrochloride
InChI:
InChI=1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H/t8-,11+;/m1./s1
InChI Key:
KAGBHVBIOJBGBD-NINOIYOQSA-N
SMILES:
Clc1ccc(cc1Cl)[C@@]12CNC[C@H]2C1.Cl
UNII:
R01R720TVG
Properties
Complexity:
245  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
263.004g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
264.574g/mol
Monoisotopic Mass:
263.004g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
12A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
The triple reuptake inhibitor DOV 216,303 induces long-lasting enhancement of brain reward activity as measured by intracranial self-stimulation in rats. European journal of pharmacology 20121015
Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. Journal of molecular neuroscience : MN 20120901
Effects of the triple reuptake inhibitor amitifadine on extracellular levels of monoamines in rat brain regions and on locomotor activity. Synapse (New York, N.Y.) 20120501
Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Journal of psychiatric research 20120101
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. Journal of psychopharmacology (Oxford, England) 20111001
1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors. Bioorganic & medicinal chemistry 20110601
The secrets of a successful clinical trial: compliance, compliance, and compliance. Molecular interventions 20110401
Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The international journal of neuropsychopharmacology 20110301
The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior 20110101
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of pharmacology and experimental therapeutics 20101201
The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. European journal of pharmacology 20100510
The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081201
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics 20080301
Triple reuptake inhibitors ('broad spectrum' antidepressants). CNS & neurological disorders drug targets 20070401
Stereocontrolled synthesis of trisubstituted cyclopropanes: expedient, atom-economical, asymmetric syntheses of (+)-Bicifadine and DOV21947. Organic letters 20060817
Preclinical and clinical pharmacology of DOV 216,303, a 'triple' reuptake inhibitor. CNS drug reviews 20060101
DOV 216,303, a 'triple' reuptake inhibitor: safety, tolerability, and pharmacokinetic profile. Journal of clinical pharmacology 20041201
'Broad spectrum' antidepressants: is more better for the treatment of depression? Life sciences 20031107
Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor. European journal of pharmacology 20030214
Properties