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Pyr-41

CAS No.:
418805-02-4
Catalog Number:
AG00C6HJ
Molecular Formula:
C17H13N3O7
Molecular Weight:
371.3010
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$91
- +
5mg
≥95%
1 week
United States
$135
- +
10mg
98%
1 week
United States
$182
- +
25mg
≥95%
1 week
United States
$308
- +
50mg
98%
1 week
United States
$557
- +
100mg
98%
1 week
United States
$835
- +
Product Description
Catalog Number:
AG00C6HJ
Chemical Name:
Pyr-41
CAS Number:
418805-02-4
Molecular Formula:
C17H13N3O7
Molecular Weight:
371.3010
MDL Number:
MFCD01469983
IUPAC Name:
ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate
InChI:
InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChI Key:
ARGIPZKQJGFSGQ-LCYFTJDESA-N
SMILES:
CCOC(=O)c1ccc(cc1)N1NC(=O)C(=Cc2ccc(o2)[N+](=O)[O-])C1=O
NSC Number:
746131
Properties
Complexity:
664  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
371.075g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
371.305g/mol
Monoisotopic Mass:
371.075g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
135A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.3  
Literature
Title Journal
Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg. Reproductive toxicology (Elmsford, N.Y.) 20180301
Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Molecular neurobiology 20161001
Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells. Chemical research in toxicology 20150420
Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways. Immunology 20140601
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell cycle (Georgetown, Tex.) 20120415
Ubiquitin-activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm-egg coat penetration during porcine fertilization. International journal of andrology 20120401
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. PLoS biology 20111001
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity. Biochemical pharmacology 20110815
The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway. Experimental cell research 20100101
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer research 20071001
Properties