Home Other Building Blocks Nnc 55-0396

Nnc 55-0396

CAS No.:
357400-13-6
Catalog Number:
AG00C6GT
Molecular Formula:
C30H40Cl2FN3O2
Molecular Weight:
564.5619
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$112
- +
5mg
≥98%
1 week
United States
$265
- +
10mg
≥98%
1 week
United States
$407
- +
25mg
≥98%
1 week
United States
$821
- +
Product Description
Catalog Number:
AG00C6GT
Chemical Name:
Nnc 55-0396
CAS Number:
357400-13-6
Molecular Formula:
C30H40Cl2FN3O2
Molecular Weight:
564.5619
MDL Number:
MFCD11878627
IUPAC Name:
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] cyclopropanecarboxylate;dihydrochloride
InChI:
InChI=1S/C30H38FN3O2.2ClH/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27;;/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33);2*1H/t28-,30-;;/m0../s1
InChI Key:
BCCQNBXHUMKLFW-HNQRYHMESA-N
SMILES:
CN(CCC1(CCc2c(C1C(C)C)ccc(c2)F)OC(=O)C1CC1)CCCc1nc2c([nH]1)cccc2.Cl.Cl
UNII:
0A7CE46ERM
Properties
Complexity:
746  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
563.248g/mol
Formal Charge:
0
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
564.567g/mol
Monoisotopic Mass:
563.248g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
58.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca(v)3.2 in mice. Toxicology 20180115
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. British journal of pharmacology 20121001
Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch. American journal of physiology. Cell physiology 20120615
The CatSper channel: a polymodal chemosensor in human sperm. The EMBO journal 20120404
Atypical Ca2+ currents in chromaffin cells from SHR and WKY rat strains result from the deficient expression of a splice variant of the α1D Ca2+ channel. American journal of physiology. Heart and circulatory physiology 20120101
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats. Neuroscience 20110811
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease. The Journal of clinical investigation 20110801
Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation. Cancer investigation 20110601
Basal sympathetic activity generated in neonatal mouse brainstem-spinal cord preparation requires T-type calcium channel subunit 1H. Experimental physiology 20110501
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature 20110317
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology 20101101
Actions of thalidomide in producing vascular relaxations. European journal of pharmacology 20101010
Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens. British journal of pharmacology 20100301
Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation. Cancer letters 20080818
Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovascular drug reviews 20050101
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. The Journal of pharmacology and experimental therapeutics 20040401
Properties