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Betrixaban

CAS No.:
330942-05-7
Catalog Number:
AG00C6EX
Molecular Formula:
C23H22ClN5O3
Molecular Weight:
451.9055
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$207
- +
10mg
98%
1 week
United States
$290
- +
25mg
≥98%
1 week
United States
$361
- +
50mg
≥98%
1 week
United States
$573
- +
100mg
≥98%
1 week
United States
$847
- +
250mg
≥98%
1 week
United States
$1426
- +
Product Description
Catalog Number:
AG00C6EX
Chemical Name:
Betrixaban
CAS Number:
330942-05-7
Molecular Formula:
C23H22ClN5O3
Molecular Weight:
451.9055
MDL Number:
MFCD16038040
IUPAC Name:
N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide
InChI:
InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)
InChI Key:
XHOLNRLADUSQLD-UHFFFAOYSA-N
SMILES:
COc1ccc(c(c1)C(=O)Nc1ccc(cn1)Cl)NC(=O)c1ccc(cc1)C(=N)N(C)C
UNII:
74RWP7W0J9
Properties
Complexity:
668  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
451.141g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
451.911g/mol
Monoisotopic Mass:
451.141g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6  
Literature
Title Journal
The role of factor Xa inhibitors in venous thromboembolism treatment. Vascular health and risk management 20150101
Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vascular health and risk management 20150101
Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa). European heart journal 20130521
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nature medicine 20130401
New oral anticoagulants: a review of the literature with particular emphasis on patients with impaired renal function. Drugs 20120910
ACP Journal Club: review: factor Xa inhibitors reduce DVT more than LMWH in total knee or hip replacement. Annals of internal medicine 20120821
The new oral anticoagulants: a challenge for hospital formularies. Hospital practice (1995) 20120801
The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review. Expert opinion on therapeutic patents 20120601
Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation. Discovery medicine 20120601
Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301
Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation. Nature reviews. Cardiology 20120227
Stroke Prevention in Atrial Fibrillation: Where are We Now? Clinical Medicine Insights. Cardiology 20120101
Current status of new anticoagulants in the management of venous thromboembolism. Advances in hematology 20120101
Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants. Journal of blood medicine 20120101
Emerging anticoagulants. Current medicinal chemistry 20120101
Update on anti-coagulation in atrial fibrillation. QJM : monthly journal of the Association of Physicians 20110901
[Thromboembolic prophylaxis 2011: is warfarin on the wane?]. Giornale italiano di cardiologia (2006) 20110901
Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20110301
New oral anticoagulants: should they replace heparins and warfarin? Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101
Role of factor xa inhibitors in cancer-associated thrombosis: any new data? Advances in hematology 20110101
Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments. Journal of the American College of Cardiology 20101214
New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors. Clinics in chest medicine 20101201
Factor Xa inhibitors: next-generation antithrombotic agents. Journal of medicinal chemistry 20100909
Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban. Journal of clinical pharmacology 20100901
Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation. Current opinion in cardiology 20100701
New anticoagulants for the prevention of venous thromboembolism. Drug design, development and therapy 20100101
Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice. F1000 medicine reports 20100101
Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations. Journal of blood medicine 20100101
Factor Xa inhibitors--new anticoagulants for secondary haemostasis. Hamostaseologie 20090801
New anticoagulants: focus on venous thromboembolism. Current vascular pharmacology 20090701
New anticoagulants for atrial fibrillation. Seminars in thrombosis and hemostasis 20090701
Rivaroxaban -- an oral, direct Factor Xa inhibitor: lessons from a broad clinical study programme. European journal of haematology 20090501
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorganic & medicinal chemistry letters 20090415
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clinical pharmacokinetics 20090101
A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thrombosis and haemostasis 20090101
The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants. Vascular health and risk management 20090101
Emergence of new oral antithrombotics: a critical appraisal of their clinical potential. Vascular health and risk management 20081201
New oral anticoagulants in atrial fibrillation. European heart journal 20080101
Oral factor Xa inhibitors for venous thromboembolism prevention in major orthopedic surgery: a review. Pathophysiology of haemostasis and thrombosis 20080101
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