Home Other Building Blocks (2,3-epoxyphytyl)menaquinone

(2,3-epoxyphytyl)menaquinone

CAS No.:
25486-55-9
Catalog Number:
AG00C2U7
Molecular Formula:
C31H46O3
Molecular Weight:
466.6951
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$300
- +
5mg
≥95%
1 week
United States
$550
- +
Product Description
Catalog Number:
AG00C2U7
Chemical Name:
(2,3-epoxyphytyl)menaquinone
CAS Number:
25486-55-9
Molecular Formula:
C31H46O3
Molecular Weight:
466.6951
MDL Number:
MFCD00870307
IUPAC Name:
7a-methyl-1a-(3,7,11,15-tetramethylhexadec-2-enyl)naphtho[2,3-b]oxirene-2,7-dione
InChI:
InChI=1S/C31H46O3/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-31-29(33)27-19-8-7-18-26(27)28(32)30(31,6)34-31/h7-8,18-20,22-24H,9-17,21H2,1-6H3
InChI Key:
KUTXFBIHPWIDJQ-UHFFFAOYSA-N
SMILES:
CC(CCCC(CCCC(C)C)C)CCC/C(=C/CC12OC2(C)C(=O)c2c(C1=O)cccc2)/C
EC Number:
247-022-9
Properties
Complexity:
737  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
466.345g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
466.706g/mol
Monoisotopic Mass:
466.345g/mol
Rotatable Bond Count:
14  
Topological Polar Surface Area:
46.7A^2
Undefined Atom Stereocenter Count:
4  
Undefined Bond Stereocenter Count:
1  
XLogP3:
10.1  
Literature
Title Journal
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. The Journal of veterinary medical science 20130201
Functional study of the vitamin K cycle in mammalian cells. Blood 20110310
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation. The Journal of biological chemistry 20110304
Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. Journal of pharmacokinetics and pharmacodynamics 20100201
A possible ethanol-catalyzed rearrangement of vitamin K(1) detected by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM 20081201
Structure and function of vitamin K epoxide reductase. Vitamins and hormones 20080101
Vitamin K-dependent carboxylation. Vitamins and hormones 20080101
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry 20070619
Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. The Journal of biological chemistry 20070126
Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proceedings of the National Academy of Sciences of the United States of America 20061219
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thrombosis and haemostasis 20051001
Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. Toxicology 20030801
Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. Blood 20021101
Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. The Journal of pharmacy and pharmacology 20010401
The association of vitamin K status with warfarin sensitivity at the onset of treatment. British journal of haematology 20010301
Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. Cancer 19940901
Patulin biosynthesis: epoxidation of toluquinol and gentisyl alcohol by particulate preparations from Penicillium patulum. Biochemistry 19891114
Properties