Home Other Building Blocks 24-Hydroxycholesterol

24-Hydroxycholesterol

CAS No.:
30271-38-6
Catalog Number:
AG00C2SB
Molecular Formula:
C27H46O2
Molecular Weight:
402.6529
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
2mg
98%
1 week
United States
$307
- +
5mg
98%
1 week
United States
$557
- +
Product Description
Catalog Number:
AG00C2SB
Chemical Name:
24-Hydroxycholesterol
CAS Number:
30271-38-6
Molecular Formula:
C27H46O2
Molecular Weight:
402.6529
MDL Number:
MFCD31544368
IUPAC Name:
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChI:
InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25?,26+,27-/m1/s1
InChI Key:
IOWMKBFJCNLRTC-GHMQSXNDSA-N
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(C(C)C)O)C)C)C1)C
Properties
Complexity:
624  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
402.35g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
402.663g/mol
Monoisotopic Mass:
402.35g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
40.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
7  
Literature
Title Journal
Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. PloS one 20140101
Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat. Acta ophthalmologica 20121101
Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. Investigative ophthalmology & visual science 20121009
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. Journal of neurochemistry 20121001
Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. Neuroscience letters 20120906
Cholesterol loss during glutamate-mediated excitotoxicity. The EMBO journal 20120404
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. Cell death and differentiation 20120301
Interactions of amyloid β peptide 1-40 and cerebrosterol. Neurochemical research 20120301
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells. Neurochemistry international 20120101
Nuclear receptors in nonalcoholic Fatty liver disease. Journal of lipids 20120101
side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. Neuro-degenerative diseases 20120101
Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. Journal of Alzheimer's disease : JAD 20120101
Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients. Lipids in health and disease 20120101
Beta-amyloid peptides enhance the proliferative response of activated CD4CD28 lymphocytes from Alzheimer disease patients and from healthy elderly. PloS one 20120101
Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. Journal of Alzheimer's disease : JAD 20120101
Spatial distribution of the pathways of cholesterol homeostasis in human retina. PloS one 20120101
ABC Transporters and the Alzheimer's Disease Enigma. Frontiers in psychiatry 20120101
Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. Journal of internal medicine 20111001
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. Chemistry and physics of lipids 20110901
Oxidative damage in ischemic stroke revealed using multiple biomarkers. Stroke 20110801
Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. The Journal of biological chemistry 20110722
24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. The Journal of biological chemistry 20110715
Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? Free radical biology & medicine 20110615
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging cell 20110601
Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. Plant foods for human nutrition (Dordrecht, Netherlands) 20110601
Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease? Experimental gerontology 20110401
Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. Journal of proteome research 20110107
Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. Investigative ophthalmology & visual science 20110101
Complex genetic mechanisms in glaucoma: an overview. Indian journal of ophthalmology 20110101
Role of cholesterol 24S-hydroxylase gene polymorphism (rs754203) in primary open angle glaucoma. Molecular vision 20110101
Lipid pathway alterations in Parkinson's disease primary visual cortex. PloS one 20110101
Mechanisms of oxysterol-induced carcinogenesis. Lipids in health and disease 20110101
Oxysterol derivatives of cholesterol in neurodegenerative disorders. Current medicinal chemistry 20110101
Function and comorbidities of apolipoprotein e in Alzheimer's disease. International journal of Alzheimer's disease 20110101
Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. Journal of ophthalmology 20110101
Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Frontiers in neurology 20110101
Processing of endogenous AβPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis. Journal of Alzheimer's disease : JAD 20110101
Lipids, lipoproteins, and age-related macular degeneration. Journal of lipids 20110101
ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. PloS one 20110101
Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC ophthalmology 20110101
Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids in health and disease 20110101
Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study. BMC neurology 20110101
Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PloS one 20110101
Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury. PloS one 20110101
The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. ISRN neurology 20110101
Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Molecular and cellular neurosciences 20101201
LXR-α genomics programmes neuronal death observed in Alzheimer's disease. Apoptosis : an international journal on programmed cell death 20101201
Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. Anticancer research 20100901
The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience 20100811
A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochimica et biophysica acta 20100801
Changes in brain cholesterol metabolome after excitotoxicity. Molecular neurobiology 20100601
Distribution of cholesterol 24-hydroxylase in the monkey brain. Neuroscience bulletin 20100601
Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease. IUBMB life 20100401
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. Brain research 20100310
Vascular pathology in the aged human brain. Acta neuropathologica 20100301
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo. Journal of lipid research 20100201
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Molecular therapy : the journal of the American Society of Gene Therapy 20100101
Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Biochimica et biophysica acta 20100101
Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. PloS one 20100101
Cardiovascular dementia - a different perspective. The open biochemistry journal 20100101
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer disease and associated disorders 20100101
Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. Pharmacology 20100101
The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. BMC ophthalmology 20100101
Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4. Alzheimer's research & therapy 20100101
Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. Investigative ophthalmology & visual science 20091201
Polar metabolite of cholesterol induces rat cognitive dysfunctions. Neuroscience 20091201
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. Neuroscience letters 20091002
24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. Drug metabolism and disposition: the biological fate of chemicals 20091001
Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. Neurobiology of aging 20090601
Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. Biochemistry 20090519
Central nervous system: cholesterol turnover, brain development and neurodegeneration. Biological chemistry 20090401
CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. European psychiatry : the journal of the Association of European Psychiatrists 20090401
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase. Archives of biochemistry and biophysics 20090301
Sterols in the central nervous system. Current opinion in clinical nutrition and metabolic care 20090301
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. Journal of lipid research 20090201
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Molecular neurodegeneration 20090101
Oxysterols as markers of neurological disease--a review. Scandinavian journal of clinical and laboratory investigation 20090101
Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease. Dementia and geriatric cognitive disorders 20090101
Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. PloS one 20090101
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. Journal of neurochemistry 20081201
A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. Bioscience, biotechnology, and biochemistry 20081201
Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. Brain : a journal of neurology 20081101
Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. Analytical biochemistry 20081001
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. Journal of neurotrauma 20080901
Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors. Journal of neurochemistry 20080701
Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. Brain injury 20080701
Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. Free radical biology & medicine 20080401
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. Journal of proteome research 20080401
Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. Neurochemical research 20080301
[Synthesis of sterols oxygenated in the terminal fragment of their side chains]. Bioorganicheskaia khimiia 20080101
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis. PPAR research 20080101
Liver x receptor: a novel therapeutic target. Indian journal of pharmaceutical sciences 20080101
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20071226
Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. Journal of neurochemistry 20071201
Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. Journal of neurochemistry 20071101
Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1. International journal of clinical pharmacology and therapeutics 20071101
Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. Neuroscience letters 20070925
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. Human molecular genetics 20070915
Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis 20070901
Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphisms. Journal of molecular neuroscience : MN 20070901
Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. Biochemical and biophysical research communications 20070720
Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). Lipids 20070701
24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. Journal of neuroscience research 20070515
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. Journal of internal medicine 20070501
Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. Journal of lipid research 20070401
Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. Current eye research 20070301
Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation. The Journal of biological chemistry 20070202
24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. Journal of neurochemistry 20070201
Rediscovery of cerebrosterol. Lipids 20070201
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell metabolism 20070101
[A new synthesis of cerebrosterol and its 24-epimer from lithocholic acid]. Bioorganicheskaia khimiia 20070101
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry. Methods in enzymology 20070101
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. Journal of internal medicine 20061201
Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. Clinical neurology and neurosurgery 20060701
High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. Journal of clinical pharmacology 20060701
Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. Journal of neuropathology and experimental neurology 20060701
24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. The Journal of biological chemistry 20060505
Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. International journal of molecular medicine 20060501
Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease. Expert review of neurotherapeutics 20060501
Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? Neuroscience letters 20060401
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. The Journal of pharmacology and experimental therapeutics 20060301
Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population. International psychogeriatrics 20060301
Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996) 20060201
Circulating biomarkers of cognitive decline and dementia. Clinica chimica acta; international journal of clinical chemistry 20060201
Effect of pravastatin on plasma sterols and oxysterols in men. European journal of clinical pharmacology 20060101
Cholesterol metabolism in the brain: importance of 24S-hydroxylation. Acta neurologica Scandinavica. Supplementum 20060101
Oxysterols and Alzheimer's disease. Acta neurologica Scandinavica. Supplementum 20060101
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. Journal of biomedicine & biotechnology 20060101
Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. Journal of neural transmission (Vienna, Austria : 1996) 20051001
A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. The Journal of clinical psychiatry 20050701
24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. Neuroreport 20050621
Effect of raloxifene and hormone therapy on serum markers of brain and whole-body cholesterol metabolism in postmenopausal women. Maturitas 20050411
Cholesterol homeostasis in neurons and glial cells. Seminars in cell & developmental biology 20050401
Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. The Lancet. Neurology 20050101
Cholesterol and apolipoprotein E in Alzheimer's disease. American journal of Alzheimer's disease and other dementias 20050101
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. PLoS biology 20041001
Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. Neuroscience letters 20040930
Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? Neuroscience letters 20040923
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. Neurobiology of aging 20040901
Differential expression of cholesterol hydroxylases in Alzheimer's disease. The Journal of biological chemistry 20040813
Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. Journal of lipid research 20040801
High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids 20040601
Brain cholesterol: long secret life behind a barrier. Arteriosclerosis, thrombosis, and vascular biology 20040501
Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. Journal of lipid research 20040401
Diagnostic use of cerebral and extracerebral oxysterols. Clinical chemistry and laboratory medicine 20040201
The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. Current Alzheimer research 20040201
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. Journal of lipid research 20040101
Linking lipids, Alzheimer's and LXRs? Nuclear receptor signaling 20040101
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry 20031209
Combination of serum markers related to several mechanisms in Alzheimer's disease. Neurobiology of aging 20031101
24S-hydroxycholesterol: a marker of brain cholesterol metabolism. Pharmacopsychiatry 20030901
Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. Neuroscience letters 20030828
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. Journal of lipid research 20030801
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. The Journal of biological chemistry 20030620
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. Journal of lipid research 20030401
Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Archives of neurology 20030401
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye. Laboratory investigation; a journal of technical methods and pathology 20030301
Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. Neurobiology of aging 20030101
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Archives of neurology 20030101
The role of 24S-hydroxycholesterol in Alzheimer's disease. The journal of nutrition, health & aging 20030101
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. The Journal of biological chemistry 20021213
Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. Neuroscience letters 20021018
Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. The Journal of biological chemistry 20020913
Metabolism of 4 beta -hydroxycholesterol in humans. The Journal of biological chemistry 20020830
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. Neuroscience letters 20020510
Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. Archives of neurology 20020201
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. Journal of psychiatric research 20020101
Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Molecular psychiatry 20020101
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neuroscience letters 20011113
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. The Journal of biological chemistry 20011019
From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. The Journal of biological chemistry 20011005
Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. Acta paediatrica (Oslo, Norway : 1992) 20010601
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. Journal of lipid research 20010301
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. Journal of lipid research 20010101
Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. Journal of neural transmission (Vienna, Austria : 1996) 20010101
24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). Journal of lipid research 20001001
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. The Journal of biological chemistry 20000602
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. The Journal of biological chemistry 19970207
24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. Biochimica et biophysica acta 19930224
Properties