5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE
| Title | Journal |
|---|---|
| Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation. | Chemico-biological interactions 20171225 |
| 4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells. | Toxicology letters 20170205 |
| Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. | Toxicology and applied pharmacology 20170201 |
| Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. | Archives of toxicology 20170101 |
| Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury. | Toxicology letters 20161116 |
| Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68). | Cellular and molecular gastroenterology and hepatology 20161101 |
| Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway. | Toxicology letters 20160906 |
| Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis. | Journal of cellular and molecular medicine 20160701 |
| Fipronil promotes adipogenesis via AMPKα-mediated pathway in 3T3-L1 adipocytes. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160601 |
| Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation. | Molecular nutrition & food research 20160301 |
| AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function. | PloS one 20160101 |
| Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK. | Life sciences 20150901 |
| Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway. | Toxicology letters 20150416 |
| Resveratrol induces cell apoptosis in adipocytes via AMPK activation. | Biochemical and biophysical research communications 20150220 |
| Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. | The Journal of toxicological sciences 20150201 |
| Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. | Cell death & disease 20141201 |
| Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. | European journal of pain (London, England) 20141101 |
| Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1. | Pharmacological research 20141101 |
| AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. | The FEBS journal 20141001 |
| Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140601 |
| Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes. | Molecular nutrition & food research 20140501 |
| Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. | British journal of pharmacology 20140501 |
| Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1. | Journal of lipid research 20140301 |
| Kir6.2-containing ATP-sensitive K(+) channel is required for cardioprotection of resveratrol in mice. | Cardiovascular diabetology 20140101 |
| Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130301 |
| Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway. | Die Pharmazie 20130201 |
| Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice. | Diabetologia 20130101 |
| Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. | PloS one 20130101 |
| AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signaling and inhibits NO-induced relaxation. | European journal of pharmacology 20121115 |
| Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells. | Diabetologia 20121101 |
| Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. | Journal of lipid research 20121101 |
| Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator. | Endocrinology 20121101 |
| AMP-activated protein kinase stimulates myostatin expression in C2C12 cells. | Biochemical and biophysical research communications 20121012 |
| AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway. | Melanoma research 20121001 |
| AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20121001 |
| The Arabidopsis F-box protein AtFBS1 interacts with 14-3-3 proteins. | Plant science : an international journal of experimental plant biology 20121001 |
| Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide. | Journal of muscle research and cell motility 20121001 |
| AMP-activated protein kinase upregulates glucose uptake in thyroid PCCL3 cells independent of thyrotropin. | Thyroid : official journal of the American Thyroid Association 20121001 |
| Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. | American journal of physiology. Gastrointestinal and liver physiology 20120915 |
| Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. | The Journal of nutritional biochemistry 20120901 |
| Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901 |
| Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells. | The Journal of pharmacology and experimental therapeutics 20120901 |
| Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice. | Planta medica 20120901 |
| The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. | American journal of physiology. Endocrinology and metabolism 20120815 |
| Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. | Molecular pharmacology 20120801 |
| Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons. | The Journal of endocrinology 20120801 |
| AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle. | Cell and tissue research 20120801 |
| Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. | The Journal of biological chemistry 20120706 |
| AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. | British journal of pharmacology 20120701 |
| Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet. | American journal of physiology. Cell physiology 20120615 |
| Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. | The Journal of biological chemistry 20120608 |
| Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. | Investigative ophthalmology & visual science 20120601 |
| In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. | Metabolism: clinical and experimental 20120501 |
| PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation. | Molecular biology reports 20120501 |
| Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. | American journal of physiology. Endocrinology and metabolism 20120501 |
| A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle. | Diabetes 20120501 |
| AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol. | Endocrinology 20120501 |
| Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism. | Mechanisms of ageing and development 20120501 |
| AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. | Circulation research 20120427 |
| Vinorelbine-induced oxidative injury in human endothelial cells mediated by AMPK/PKC/NADPH/NF-κB pathways. | Cell biochemistry and biophysics 20120401 |
| AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. | The Biochemical journal 20120401 |
| AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats. | Journal of hypertension 20120401 |
| Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. | Cancer prevention research (Philadelphia, Pa.) 20120401 |
| Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. | Biochemical and biophysical research communications 20120323 |
| Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter. | Molecular pharmacology 20120301 |
| AMP-activated protein kinase connects cellular energy metabolism to KATP channel function. | Journal of molecular and cellular cardiology 20120201 |
| Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase. | International journal of oncology 20120201 |
| AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. | Journal of cellular biochemistry 20120201 |
| AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. | Nature medicine 20120201 |
| Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile. | Mitochondrion 20120101 |
| Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle. | American journal of physiology. Cell physiology 20120101 |
| Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK). | Molecular and cellular biochemistry 20120101 |
| AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy. | Diabetologia 20120101 |
| Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism? | Medical hypotheses 20120101 |
| Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry (UPLC-Q-ToF-MS). | Analytical and bioanalytical chemistry 20120101 |
| Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. | Biological & pharmaceutical bulletin 20120101 |
| Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. | PloS one 20120101 |
| Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake. | Neuroendocrinology 20120101 |
| AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells. | PloS one 20120101 |
| Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. | PloS one 20120101 |
| MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. | PloS one 20120101 |
| Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells. | The Journal of toxicological sciences 20120101 |
| 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells. | Biochemical and biophysical research communications 20111209 |
| Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. | Blood 20111208 |
| Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways. | Stem cells and development 20111201 |
| Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20111201 |
| 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. | The Journal of pharmacology and experimental therapeutics 20111201 |
| Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology. | American journal of physiology. Cell physiology 20111201 |
| AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. | Arteriosclerosis, thrombosis, and vascular biology 20111201 |
| 5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells. | International journal of radiation oncology, biology, physics 20111201 |
| A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection. | The Yale journal of biology and medicine 20111201 |
| AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. | The International journal of artificial organs 20111201 |
| Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. | The Journal of biological chemistry 20111125 |
| Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation. | Investigative ophthalmology & visual science 20111125 |
| Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts. | Biochemical and biophysical research communications 20111118 |
| Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations. | Toxicology and applied pharmacology 20111115 |
| AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle. | Biochemical and biophysical research communications 20111104 |
| Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes. | Molecular and cellular endocrinology 20111015 |
| Central AMP-activated protein kinase affects sympathetic nerve activity in rats. | Neuroscience letters 20111010 |
| Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. | Journal of clinical pharmacology 20111001 |
| The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide-ribonucleoside. | The Journal of endocrinology 20111001 |
| Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway. | The American journal of pathology 20111001 |
| Angiotensin II upregulates protein phosphatase 2Cα and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting. | Hypertension (Dallas, Tex. : 1979) 20111001 |
| Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20111001 |
| Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose. | Molecules (Basel, Switzerland) 20110921 |
| Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. | Toxicology and applied pharmacology 20110915 |
| Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast. | The Journal of biological chemistry 20110902 |
| AMP-activated protein kinase regulates normal rat somatotroph cell function and growth of rat pituitary adenomatous cells. | Pituitary 20110901 |
| Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats. | Journal of physiology and biochemistry 20110901 |
| Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice. | American journal of physiology. Endocrinology and metabolism 20110901 |
| Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle. | Human molecular genetics 20110901 |
| Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content. | Journal of applied physiology (Bethesda, Md. : 1985) 20110901 |
| Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity. | Journal of lipid research 20110901 |
| Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells. | Anatomy & cell biology 20110901 |
| Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. | Investigative ophthalmology & visual science 20110822 |
| Antagonistic control of muscle cell size by AMPK and mTORC1. | Cell cycle (Georgetown, Tex.) 20110815 |
| AICAR and Compound C regulate food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low body weight. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110801 |
| Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I. | Molecular endocrinology (Baltimore, Md.) 20110801 |
| Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway. | Chinese medical journal 20110801 |
| AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. | Neuroscience letters 20110725 |
| In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis. | Cell metabolism 20110706 |
| Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells. | American journal of respiratory cell and molecular biology 20110701 |
| Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes. | Amino acids 20110701 |
| AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes. | International journal of molecular medicine 20110701 |
| Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. | Journal of cellular physiology 20110701 |
| AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway. | Archives of biochemistry and biophysics 20110701 |
| Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle. | American journal of physiology. Regulatory, integrative and comparative physiology 20110701 |
| LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology. | Cell cycle (Georgetown, Tex.) 20110701 |
| Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade. | Cell calcium 20110701 |
| Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α. | The Journal of membrane biology 20110701 |
| Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise. | The Journal of veterinary medical science 20110601 |
| A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland. | American journal of physiology. Cell physiology 20110601 |
| AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes. | American journal of physiology. Endocrinology and metabolism 20110601 |
| α₂-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes. | Journal of neurochemistry 20110601 |
| Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. | The Journal of clinical investigation 20110601 |
| AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation. | Biochimica et biophysica acta 20110601 |
| Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase. | Chinese medical journal 20110601 |
| Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. | Nutrition research (New York, N.Y.) 20110601 |
| AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake. | Archives of biochemistry and biophysics 20110515 |
| AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5. | The Journal of biological chemistry 20110506 |
| Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). | Molecular and biochemical parasitology 20110501 |
| Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report. | Arteriosclerosis, thrombosis, and vascular biology 20110501 |
| AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. | American journal of physiology. Endocrinology and metabolism 20110501 |
| Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. | Clinical and experimental pharmacology & physiology 20110501 |
| Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase. | Molecular endocrinology (Baltimore, Md.) 20110501 |
| Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction. | Oral oncology 20110501 |
| Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice. | Hypertension (Dallas, Tex. : 1979) 20110501 |
| Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. | Nature immunology 20110501 |
| Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet. | Drug testing and analysis 20110501 |
| Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice. | FEBS letters 20110420 |
| AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. | Science (New York, N.Y.) 20110408 |
| Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells. | Journal of cellular physiology 20110401 |
| Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm. | Acta physiologica (Oxford, England) 20110401 |
| Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients. | Biochimica et biophysica acta 20110401 |
| Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. | The Journal of pharmacology and experimental therapeutics 20110401 |
| Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions. | American journal of physiology. Heart and circulatory physiology 20110401 |
| Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. | The Journal of biological chemistry 20110401 |
| Activation of AMP-kinase by policosanol requires peroxisomal metabolism. | Lipids 20110401 |
| Leptin controls ketone body utilization in hypothalamic neuron. | Neuroscience letters 20110303 |
| Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle. | Metabolism: clinical and experimental 20110301 |
| Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. | Free radical biology & medicine 20110301 |
| AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia. | Molecular cancer therapeutics 20110301 |
| Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle. | Diabetes 20110301 |
| Identification of aneuploidy-selective antiproliferation compounds. | Cell 20110218 |
| Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction. | Journal of immunology (Baltimore, Md. : 1950) 20110215 |
| Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo. | Journal of cardiothoracic and vascular anesthesia 20110201 |
| Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation. | American journal of physiology. Endocrinology and metabolism 20110201 |
| Plasticity in the purine-thiamine metabolic network of Salmonella. | Genetics 20110201 |
| Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. | Clinical and experimental pharmacology & physiology 20110201 |
| Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep. | American journal of physiology. Regulatory, integrative and comparative physiology 20110201 |
| Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase. | Molecular membrane biology 20110201 |
| Endurance factors improve hippocampal neurogenesis and spatial memory in mice. | Learning & memory (Cold Spring Harbor, N.Y.) 20110201 |
| AMP-activated protein kinase inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells. | Cardiovascular drugs and therapy 20110201 |
| The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. | Diabetes 20110201 |
| Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding. | Diabetes 20110201 |
| AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells. | Biochemical and biophysical research communications 20110128 |
| AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle. | Life sciences 20110117 |
| Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L. | The Journal of biological chemistry 20110107 |
| Does long-term metformin treatment increase cardiac lipoprotein lipase? | Metabolism: clinical and experimental 20110101 |
| Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice. | Cardiovascular research 20110101 |
| Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent. | American journal of physiology. Heart and circulatory physiology 20110101 |
| Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. | American journal of physiology. Heart and circulatory physiology 20110101 |
| Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| An invertebrate hyperglycemic model for the identification of anti-diabetic drugs. | PloS one 20110101 |
| Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription. | International journal of biological sciences 20110101 |
| Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. | PloS one 20110101 |
| The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK? | BMC neuroscience 20110101 |
| The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. | Mechanisms of ageing and development 20110101 |
| Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound. | PloS one 20110101 |
| Metabolic specialization of mouse embryonic stem cells. | Cold Spring Harbor symposia on quantitative biology 20110101 |
| Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients. | PloS one 20110101 |
| Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition. | Oncogene 20101216 |
| Adenosine regulates Sertoli cell function by activating AMPK. | Molecular and cellular endocrinology 20101215 |
| Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. | Cancer research 20101215 |
| AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis. | Biochemical pharmacology 20101201 |
| Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells. | American journal of physiology. Cell physiology 20101201 |
| AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. | American journal of physiology. Regulatory, integrative and comparative physiology 20101201 |
| AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. | American journal of physiology. Renal physiology 20101201 |
| AMPK as a therapeutic target in renal cell carcinoma. | Cancer biology & therapy 20101201 |
| AMPK signaling: a targetable tumor suppressor pathway? | Cancer biology & therapy 20101201 |
| AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. | The Journal of biological chemistry 20101112 |
| AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). | Diabetologia 20101101 |
| Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain. | Chemical biology & drug design 20101101 |
| [Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101101 |
| Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. | The Journal of biological chemistry 20101022 |
| AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway. | Biochemical pharmacology 20101015 |
| Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. | The Biochemical journal 20101015 |
| 5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB. | Immunology and cell biology 20101001 |
| Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. | Peptides 20101001 |
| Hypothalamic AMP-activated protein kinase regulates glucose production. | Diabetes 20101001 |
| Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. | Diabetes 20101001 |
| Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation. | Molecular reproduction and development 20101001 |
| Studies on ligand binding to histidine triad nucleotide binding protein 1. | Bioorganic & medicinal chemistry 20100915 |
| AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds. | The Journal of experimental biology 20100915 |
| Coordinated maintenance of muscle cell size control by AMP-activated protein kinase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100901 |
| {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. | American journal of physiology. Endocrinology and metabolism 20100901 |
| PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20100901 |
| AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK. | Molecular endocrinology (Baltimore, Md.) 20100901 |
| Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes. | Journal of cellular biochemistry 20100815 |
| AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons. | Neuroscience 20100811 |
| Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100801 |
| AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. | Bone 20100801 |
| A pharmacological activator of AMP-activated protein kinase protects hypoxic neurons in a concentration-dependent manner. | Neurochemical research 20100801 |
| Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and proliferation. | Cryobiology 20100801 |
| Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle. | Journal of applied physiology (Bethesda, Md. : 1985) 20100801 |
| AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARalpha, but not PPARgamma, in rat insulinoma cell line INS-1. | Acta pharmacologica Sinica 20100801 |
| 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner. | The Journal of toxicological sciences 20100801 |
| siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells. | The Journal of toxicological sciences 20100801 |
| AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival. | Biochemical and biophysical research communications 20100716 |
| Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. | Arteriosclerosis, thrombosis, and vascular biology 20100701 |
| The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. | American journal of physiology. Gastrointestinal and liver physiology 20100701 |
| Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. | American journal of physiology. Renal physiology 20100701 |
| Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro. | Acta pharmacologica Sinica 20100701 |
| Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. | British journal of pharmacology 20100701 |
| Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. | The Journal of biological chemistry 20100618 |
| To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris). | The Journal of experimental biology 20100615 |
| AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. | Biochemical and biophysical research communications 20100604 |
| AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. | American journal of respiratory cell and molecular biology 20100601 |
| Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion. | Arteriosclerosis, thrombosis, and vascular biology 20100601 |
| Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. | The Journal of pharmacology and experimental therapeutics 20100601 |
| Stimulators of AMP-activated kinase (AMPK) inhibit seawater- but not cAMP-induced oocyte maturation in a marine worm: Implications for interactions between cAMP and AMPK signaling. | Molecular reproduction and development 20100601 |
| In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake. | Pflugers Archiv : European journal of physiology 20100601 |
| Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells. | Anticancer research 20100601 |
| Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes. | American journal of physiology. Heart and circulatory physiology 20100501 |
| Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts. | Experimental & molecular medicine 20100430 |
| AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. | Circulation research 20100402 |
| Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. | Diabetologia 20100401 |
| Quantification of urinary AICAR concentrations as a matter of doping controls. | Analytical and bioanalytical chemistry 20100401 |
| Short-term AMP-regulated protein kinase activation enhances insulin-sensitive fatty acid uptake and increases the effects of insulin on fatty acid oxidation in L6 muscle cells. | Experimental biology and medicine (Maywood, N.J.) 20100401 |
| Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. | Experimental & molecular medicine 20100331 |
| AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. | The Journal of biological chemistry 20100319 |
| Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation. | Oncogene 20100318 |
| Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways. | Experimental cell research 20100310 |
| Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes. | Journal of applied physiology (Bethesda, Md. : 1985) 20100301 |
| Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase . | Biochemistry 20100202 |
| Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species. | Free radical research 20100201 |
| Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. | American journal of physiology. Cell physiology 20100201 |
| Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia. | Naunyn-Schmiedeberg's archives of pharmacology 20100201 |
| Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction. | Cardiovascular drugs and therapy 20100201 |
| AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures. | Neurotoxicology 20100101 |
| Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells. | Journal of endocrinological investigation 20100101 |
| Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Metabolic regulation of neuronal plasticity by the energy sensor AMPK. | PloS one 20100101 |
| PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts. | Molecular medicine (Cambridge, Mass.) 20100101 |
| Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures. | Pharmacological reports : PR 20100101 |
| Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells. | Islets 20100101 |
| Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells. | Biochemical and biophysical research communications 20091218 |
| Development of hepatic fibrosis occurs normally in AMPK-deficient mice. | Clinical science (London, England : 1979) 20091214 |
| Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation. | The Journal of biological chemistry 20091211 |
| Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells. | Atherosclerosis 20091201 |
| The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics. | The international journal of biochemistry & cell biology 20091201 |
| SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase. | Virus research 20091201 |
| Osteoblast differentiation is functionally associated with decreased AMP kinase activity. | Journal of cellular physiology 20091201 |
| CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. | American journal of physiology. Regulatory, integrative and comparative physiology 20091201 |
| Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes. | FEBS letters 20091119 |
| Anergic T cells are metabolically anergic. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101 |
| Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. | Diabetologia 20091101 |
| Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids. | American journal of physiology. Endocrinology and metabolism 20091101 |
| Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. | Biochemical and biophysical research communications 20091016 |
| AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. | Science (New York, N.Y.) 20091016 |
| Police find range of drugs after trawling bins used by Tour de France cyclists. | BMJ (Clinical research ed.) 20091013 |
| Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway. | European journal of pharmacology 20091012 |
| C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. | The Journal of biological chemistry 20091009 |
| Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. | Diabetes 20091001 |
| Chronic activation of 5'-AMP-activated protein kinase changes myosin heavy chain expression in growing pigs. | Journal of animal science 20091001 |
| Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice. | American journal of physiology. Endocrinology and metabolism 20091001 |
| Fatty acid oxidation and meiotic resumption in mouse oocytes. | Molecular reproduction and development 20090901 |
| AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. | American journal of physiology. Cell physiology 20090901 |
| Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. | The Journal of endocrinology 20090901 |
| Central AMPK contributes to sleep homeostasis in mice. | Neuropharmacology 20090901 |
| Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes. | Clinical science (London, England : 1979) 20090814 |
| The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. | Proceedings of the National Academy of Sciences of the United States of America 20090804 |
| Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity. | European journal of clinical investigation 20090801 |
| AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism. | American journal of physiology. Endocrinology and metabolism 20090801 |
| Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20090801 |
| Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. | Annals of the New York Academy of Sciences 20090801 |
| Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. | Annals of the New York Academy of Sciences 20090801 |
| Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR-induced AMPK activation. | Obesity (Silver Spring, Md.) 20090701 |
| PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice. | American journal of physiology. Endocrinology and metabolism 20090701 |
| Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation. | American journal of physiology. Endocrinology and metabolism 20090701 |
| Effects of AMPK activators on the sub-cellular distribution of fatty acid transporters CD36 and FABPpm. | Archives of physiology and biochemistry 20090701 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases myocardial glucose uptake during reperfusion and induces late pre-conditioning: potential role of AMP-activated protein kinase. | Basic & clinical pharmacology & toxicology 20090701 |
| Adiponectin decreases pyruvate dehydrogenase kinase 4 gene expression in obese- and diabetic-derived myotubes. | Diabetes, obesity & metabolism 20090701 |
| Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. | Cancer research 20090701 |
| Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways. | Genes & development 20090615 |
| Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). | Cell biology and toxicology 20090601 |
| Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma. | Molecular and cellular biochemistry 20090601 |
| Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. | Journal of molecular and cellular cardiology 20090601 |
| Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes. | American journal of physiology. Regulatory, integrative and comparative physiology 20090601 |
| Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats. | Diabetologia 20090601 |
| AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. | Biochemical pharmacology 20090601 |
| Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells. | Clinical and experimental immunology 20090601 |
| Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. | Neuroscience letters 20090522 |
| Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. | Circulation 20090519 |
| Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. | Journal of medicinal chemistry 20090514 |
| Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. | Oncogene 20090507 |
| Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance. | Endocrinology 20090501 |
| A myosin II ATPase inhibitor reduces force production, glucose transport, and phosphorylation of AMPK and TBC1D1 in electrically stimulated rat skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20090501 |
| Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. | American journal of physiology. Endocrinology and metabolism 20090501 |
| Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. | American journal of physiology. Endocrinology and metabolism 20090501 |
| AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. | Acta physiologica (Oxford, England) 20090501 |
| AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle. | The Journal of physiology 20090501 |
| AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. | Nature 20090423 |
| The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis. | The Journal of physiology 20090415 |
| Regulation of erythrocyte survival by AMP-activated protein kinase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401 |
| Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. | Journal of lipid research 20090401 |
| Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum. | Biochimica et biophysica acta 20090401 |
| Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate. | American journal of physiology. Regulatory, integrative and comparative physiology 20090401 |
| AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. | American journal of physiology. Cell physiology 20090401 |
| AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. | Clinical science (London, England : 1979) 20090401 |
| AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. | Journal of cellular and molecular medicine 20090401 |
| [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae]. | Genetika 20090401 |
| AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. | Experimental & molecular medicine 20090331 |
| [Doping in the next generation: wringing extra performance from the genotype]. | MMW Fortschritte der Medizin 20090319 |
| AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D. | The Journal of biological chemistry 20090306 |
| Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090304 |
| Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. | American journal of respiratory cell and molecular biology 20090301 |
| Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090301 |
| Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. | Biochimica et biophysica acta 20090301 |
| Exercise: it's the real thing! | Nutrition reviews 20090301 |
| Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells. | Hypertension research : official journal of the Japanese Society of Hypertension 20090301 |
| AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. | Circulation research 20090227 |
| Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. | Biochemical and biophysical research communications 20090227 |
| Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. | Endocrinology 20090201 |
| Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. | American journal of physiology. Cell physiology 20090201 |
| AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase. | Microcirculation (New York, N.Y. : 1994) 20090201 |
| A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell. | Hypertension research : official journal of the Japanese Society of Hypertension 20090201 |
| 2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase. | Neuroscience letters 20090116 |
| AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase. | Biochemical and biophysical research communications 20090116 |
| Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase. | Bioorganic & medicinal chemistry 20090115 |
| Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition. | Journal of cellular physiology 20090101 |
| Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise. | American journal of physiology. Endocrinology and metabolism 20090101 |
| Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts. | Endocrine journal 20090101 |
| Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle. | American journal of physiology. Cell physiology 20090101 |
| Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. | American journal of physiology. Endocrinology and metabolism 20090101 |
| Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells. | American journal of physiology. Cell physiology 20090101 |
| Inhibition of cervical cancer cell growth through activation of upstream kinases of AMP-activated protein kinase. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20090101 |
| Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries. | PloS one 20090101 |
| Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase. | Advances in experimental medicine and biology 20090101 |
| Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha. | Journal of medicinal chemistry 20081225 |
| Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. | Biochemistry 20081216 |
| AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise. | The Journal of physiology 20081215 |
| AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. | The Journal of biological chemistry 20081205 |
| Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. | Arteriosclerosis, thrombosis, and vascular biology 20081201 |
| The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro. | American journal of physiology. Endocrinology and metabolism 20081201 |
| Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. | Diabetes 20081201 |
| AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. | The Journal of physiology 20081201 |
| Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli. | Journal of molecular histology 20081201 |
| Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. | The Journal of biological chemistry 20081121 |
| Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. | Biochemical and biophysical research communications 20081121 |
| Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways. | American journal of physiology. Cell physiology 20081101 |
| Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment. | Journal of applied physiology (Bethesda, Md. : 1985) 20081101 |
| Is ZMP the toxic metabolite in Lesch-Nyhan disease? | Medical hypotheses 20081101 |
| Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. | Journal of biochemistry 20081101 |
| AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers. | American journal of physiology. Lung cellular and molecular physiology 20081101 |
| Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20081101 |
| Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. | Molecular endocrinology (Baltimore, Md.) 20081101 |
| Are 'exercise pills' the answer to the growing problem of physical inactivity? | British journal of sports medicine 20081101 |
| AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. | European journal of pharmacology 20081024 |
| The exercise pill--too good to be true? | The New England journal of medicine 20081023 |
| AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. | Arteriosclerosis, thrombosis, and vascular biology 20081001 |
| Globular adiponectin stimulates glucose transport in type 2 diabetic muscle. | Diabetes/metabolism research and reviews 20081001 |
| Can patients with type 2 diabetes be treated with 5'-AMP-activated protein kinase activators? | Diabetologia 20081001 |
| Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. | Diabetologia 20081001 |
| Small molecules can have big effects on endurance. | Nature chemical biology 20081001 |
| Potential role of lipin-1 in exercise-induced mitochondrial biogenesis. | Biochemical and biophysical research communications 20080926 |
| The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells. | Molecular and cellular endocrinology 20080924 |
| Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. | Circulation 20080923 |
| AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells. | The Journal of physiology 20080915 |
| Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. | Endocrinology 20080901 |
| AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels. | Journal of molecular endocrinology 20080901 |
| Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. | American journal of physiology. Lung cellular and molecular physiology 20080901 |
| Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. | American journal of physiology. Cell physiology 20080901 |
| AMPK and PPARdelta agonists are exercise mimetics. | Cell 20080808 |
| Na(+)-K (+) pump location and translocation during muscle contraction in rat skeletal muscle. | Pflugers Archiv : European journal of physiology 20080801 |
| Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance. | American journal of physiology. Endocrinology and metabolism 20080801 |
| AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. | Bone 20080801 |
| Effect of fasting on PPARgamma and AMPK activity in adipocytes. | Diabetes research and clinical practice 20080801 |
| Can exercise mimetics substitute for exercise? | Cell metabolism 20080801 |
| SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. | The Journal of biological chemistry 20080718 |
| Role of AMP-activated protein kinase in the control of appetite. | Journal of neuroendocrinology 20080701 |
| AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)-JNK (c-Jun N-terminal kinase)-ATF3 (activating transcription factor 3) pathway. | Biochemical and biophysical research communications 20080613 |
| Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. | Experimental cell research 20080610 |
| Enterostatin inhibition of angiogenesis: possible role of pAMPK and vascular endothelial growth factor A (VEGF-A). | International journal of obesity (2005) 20080601 |
| AMP-activated protein kinase is essential for survival in chronic hypoxia. | Biochemical and biophysical research communications 20080530 |
| Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. | The Journal of biological chemistry 20080411 |
| Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase. | Endocrinology 20080401 |
| 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes. | Endocrinology 20080401 |
| Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. | American journal of physiology. Renal physiology 20080401 |
| alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments. | The Journal of biological chemistry 20080314 |
| AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. | The Journal of biological chemistry 20080307 |
| Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. | Molecular endocrinology (Baltimore, Md.) 20080301 |
| AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions. | Journal of applied physiology (Bethesda, Md. : 1985) 20080301 |
| The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats. | Journal of neuroendocrinology 20080301 |
| Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. | American journal of physiology. Regulatory, integrative and comparative physiology 20080301 |
| Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells. | Investigative ophthalmology & visual science 20080301 |
| AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. | Journal of pharmacological sciences 20080301 |
| IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells. | Domestic animal endocrinology 20080201 |
| Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism. | Journal of applied physiology (Bethesda, Md. : 1985) 20080201 |
| AMP-activated protein kinase phosphorylates transcription factors of the CREB family. | Journal of applied physiology (Bethesda, Md. : 1985) 20080201 |
| Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. | Hepatology (Baltimore, Md.) 20080201 |
| High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. | Hepatology (Baltimore, Md.) 20080201 |
| Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. | Journal of neuroscience methods 20080130 |
| Transcriptional mechanism of suppression of insulin gene expression by AMP-activated protein kinase activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in beta-cells. | Biochemical and biophysical research communications 20080125 |
| AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade. | Biochemical pharmacology 20080115 |
| AMPK activation with AICAR provokes an acute fall in plasma [K+]. | American journal of physiology. Cell physiology 20080101 |
| Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes. | Archives of medical research 20080101 |
| Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions. | Cancer cell 20080101 |
| An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. | Cancer cell 20080101 |
| Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. | PloS one 20080101 |
| Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. | Molecular cancer 20080101 |
| AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. | PloS one 20080101 |
| Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101 |
| AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. | Molecular and cellular biochemistry 20071201 |
| LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. | American journal of physiology. Endocrinology and metabolism 20071201 |
| Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. | American journal of physiology. Endocrinology and metabolism 20071201 |
| AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells. | Acta pharmacologica Sinica 20071201 |
| Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes. | Current diabetes reports 20071201 |
| Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. | The Journal of biological chemistry 20071109 |
| Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes. | American journal of physiology. Endocrinology and metabolism 20071101 |
| Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes. | Endocrinology 20071101 |
| Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. | American journal of physiology. Endocrinology and metabolism 20071101 |
| A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia. | Endocrinology 20071101 |
| Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20071101 |
| Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle. | Biochemical and biophysical research communications 20071019 |
| Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. | The Biochemical journal 20071015 |
| Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20071001 |
| Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. | Experimental cell research 20071001 |
| Structural insight into AMPK regulation: ADP comes into play. | Structure (London, England : 1993) 20071001 |
| Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. | The Journal of biological chemistry 20070914 |
| AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations. | Diabetes 20070901 |
| Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms. | American journal of physiology. Cell physiology 20070901 |
| Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists. | Molecular & cellular biomechanics : MCB 20070901 |
| Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha. | Experimental & molecular medicine 20070831 |
| Fatty acid synthase gene regulation in primary hypothalamic neurons. | Neuroscience letters 20070823 |
| Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro. | Molecular reproduction and development 20070801 |
| Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle. | The Journal of physiology 20070801 |
| Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells. | British journal of pharmacology 20070801 |
| AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes. | Bioscience, biotechnology, and biochemistry 20070701 |
| Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice. | The Journal of physiology 20070615 |
| Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress. | Regulatory peptides 20070607 |
| AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. | American journal of physiology. Endocrinology and metabolism 20070601 |
| A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. | American journal of physiology. Endocrinology and metabolism 20070601 |
| Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells. | American journal of physiology. Endocrinology and metabolism 20070601 |
| S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. | Cell metabolism 20070601 |
| Role of glycogen content in insulin resistance in human muscle cells. | Journal of cellular physiology 20070501 |
| Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. | American journal of physiology. Endocrinology and metabolism 20070501 |
| Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP. | Acta crystallographica. Section D, Biological crystallography 20070501 |
| Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. | The Journal of biological chemistry 20070427 |
| Resveratrol stimulates AMP kinase activity in neurons. | Proceedings of the National Academy of Sciences of the United States of America 20070424 |
| An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside. | Bioorganic & medicinal chemistry letters 20070415 |
| AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. | Cellular signalling 20070401 |
| Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes. | Biology of reproduction 20070401 |
| Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus. | American journal of physiology. Regulatory, integrative and comparative physiology 20070401 |
| Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase. | Journal of animal science 20070401 |
| Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy. | Journal of cellular biochemistry 20070401 |
| AMP-activated protein kinase mediates carotid body excitation by hypoxia. | The Journal of biological chemistry 20070316 |
| Meiotic induction by heat stress in mouse oocytes: involvement of AMP-activated protein kinase and MAPK family members. | Biology of reproduction 20070301 |
| Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle. | Journal of applied physiology (Bethesda, Md. : 1985) 20070301 |
| Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK). | Biology of reproduction 20070301 |
| Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. | Endocrinology 20070301 |
| Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: a way of protecting rat steatotic livers. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301 |
| Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation. | The Journal of biological chemistry 20070216 |
| AMP-activated protein kinase in metabolic control and insulin signaling. | Circulation research 20070216 |
| Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. | Cell metabolism 20070207 |
| Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects? | Antioxidants & redox signaling 20070201 |
| Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase. | American journal of physiology. Cell physiology 20070101 |
| 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. | American journal of physiology. Heart and circulatory physiology 20070101 |
| Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. | American journal of physiology. Cell physiology 20070101 |
| Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle. | American journal of physiology. Endocrinology and metabolism 20070101 |
| Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. | Diabetologia 20070101 |
| Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. | Free radical biology & medicine 20070101 |
| Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. | Annals of the New York Academy of Sciences 20070101 |
| Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. | Molecular cancer 20070101 |
| Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues. | Nucleosides, nucleotides & nucleic acids 20070101 |
| Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead. | Journal of medicinal chemistry 20061228 |
| [Effects of globular adiponectin, glucose and free fatty acid on AMPK and ACC phosphorylation in INS-1 beta cells]. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218 |
| Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. | Molecular pharmacology 20061201 |
| AMP-activated protein kinase and the regulation of autophagic proteolysis. | The Journal of biological chemistry 20061117 |
| Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol. | The Journal of biological chemistry 20061110 |
| Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion. | American journal of physiology. Endocrinology and metabolism 20061101 |
| Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle. | Endocrinology 20061101 |
| AICAR inhibits the Na+/H+ exchanger in rat hearts--possible contribution to cardioprotection. | Pflugers Archiv : European journal of physiology 20061101 |
| The effects of 5-aminoimidazole-4-carboxamide riboside on the pancreas in neonatal streptozotocin-diabetic rats. | Acta diabetologica 20061101 |
| Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. | The Journal of biological chemistry 20061027 |
| Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. | Cancer research 20061015 |
| TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. | Cellular signalling 20061001 |
| Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. | Diabetes 20061001 |
| Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. | Diabetes 20061001 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. | The Journal of biological chemistry 20060908 |
| Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation. | American journal of physiology. Endocrinology and metabolism 20060901 |
| The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. | The Journal of clinical endocrinology and metabolism 20060901 |
| Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis. | The American journal of pathology 20060901 |
| The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901 |
| Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. | Molecular cancer therapeutics 20060901 |
| 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. | Journal of neuroscience research 20060815 |
| Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060802 |
| Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. | Molecular and cellular biochemistry 20060801 |
| Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. | Diabetes 20060801 |
| Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti. | Biochemistry 20060711 |
| A(1) adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. | Neurotoxicology 20060701 |
| Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. | American journal of physiology. Endocrinology and metabolism 20060701 |
| AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. | Diabetes 20060701 |
| Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. | Diabetes 20060701 |
| S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. | Gastroenterology 20060701 |
| AMP-activated protein kinase activation modulates progesterone secretion in granulosa cells from hen preovulatory follicles. | The Journal of endocrinology 20060701 |
| Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. | Hypertension (Dallas, Tex. : 1979) 20060601 |
| AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. | Biochemical pharmacology 20060528 |
| Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone. | Biochemical and biophysical research communications 20060512 |
| Human resistin promotes macrophage lipid accumulation. | Diabetologia 20060501 |
| AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1. | Biochemical and biophysical research communications 20060421 |
| Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. | The Biochemical journal 20060401 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. | Diabetes 20060401 |
| 5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism. | Cancer research 20060401 |
| AMPK regulation of mouse oocyte meiotic resumption in vitro. | Developmental biology 20060315 |
| Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. | American journal of physiology. Endocrinology and metabolism 20060301 |
| Oleic acid uptake by in vitro English sparrow skeletal muscle. | Journal of experimental zoology. Part A, Comparative experimental biology 20060301 |
| AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: mediation by alpha1-adrenoceptors causing glucose uptake. | Diabetes 20060301 |
| AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. | Biochemical and biophysical research communications 20060203 |
| AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. | Biochemical and biophysical research communications 20060203 |
| Role of 5'-AMP-activated protein kinase in stimulation of glucose transport in response to inhibition of oxidative phosphorylation. | American journal of physiology. Cell physiology 20060201 |
| Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. | Journal of lipid research 20060201 |
| Activation of AMP-activated protein kinase enhances angiotensin ii-induced proliferation in cardiac fibroblasts. | Hypertension (Dallas, Tex. : 1979) 20060201 |
| Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | Immunology and cell biology 20060201 |
| Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. | Diabetes 20060101 |
| A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein. | Molecular biotechnology 20060101 |
| Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? | Advances in experimental medicine and biology 20060101 |
| AMPK or ZMPK? | Medical hypotheses 20060101 |
| A role for hypothalamic malonyl-CoA in the control of food intake. | The Journal of biological chemistry 20051202 |
| AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK. | Biochemical and biophysical research communications 20051202 |
| Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase. | American journal of physiology. Endocrinology and metabolism 20051201 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin. | American journal of physiology. Endocrinology and metabolism 20051201 |
| Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation. | Journal of hepatology 20051201 |
| Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. | American journal of physiology. Endocrinology and metabolism 20051201 |
| Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling. | Diabetologia 20051201 |
| Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo. | Diabetologia 20051201 |
| AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. | Alcoholism, clinical and experimental research 20051201 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. | The Journal of biological chemistry 20051125 |
| AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle. | The Journal of biological chemistry 20051125 |
| AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. | Circulation research 20051028 |
| Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression. | Circulation research 20051014 |
| Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. | American journal of physiology. Endocrinology and metabolism 20051001 |
| Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. | Endocrinology 20051001 |
| DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae. | Eukaryotic cell 20051001 |
| AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. | Journal of applied physiology (Bethesda, Md. : 1985) 20050901 |
| Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle. | The Journal of physiology 20050901 |
| Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. | European journal of pharmacology 20050822 |
| The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. | The Journal of biological chemistry 20050812 |
| Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. | The Journal of physiology 20050801 |
| Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. | Life sciences 20050729 |
| Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701 |
| 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. | Journal of immunology (Baltimore, Md. : 1950) 20050701 |
| The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. | Oncogene 20050616 |
| Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. | American journal of physiology. Endocrinology and metabolism 20050601 |
| AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle. | The Journal of physiology 20050601 |
| AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle. | The Journal of physiology 20050601 |
| Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. | Diabetologia 20050601 |
| Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. | The Journal of biological chemistry 20050527 |
| Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. | The EMBO journal 20050518 |
| Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. | American journal of physiology. Endocrinology and metabolism 20050501 |
| Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. | Genetics 20050501 |
| AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. | Circulation research 20050429 |
| The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. | FEBS letters 20050425 |
| Long-term AICAR administration and exercise prevents diabetes in ZDF rats. | Diabetes 20050401 |
| Synthesis of a methylene analog of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate (ZMP). | Bioscience, biotechnology, and biochemistry 20050401 |
| A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis. | The Journal of biological chemistry 20050325 |
| Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. | Cancer research 20050315 |
| AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. | Biochemical and biophysical research communications 20050311 |
| Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. | The Biochemical journal 20050301 |
| AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. | American journal of physiology. Endocrinology and metabolism 20050301 |
| Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism. | Diabetes 20050301 |
| Dual mechanisms regulating AMPK kinase action in the ischemic heart. | Circulation research 20050218 |
| Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio. | American journal of physiology. Regulatory, integrative and comparative physiology 20050201 |
| MEK inhibitors block AICAR-induced maturation in mouse oocytes by a MAPK-independent mechanism. | Molecular reproduction and development 20050201 |
| Glucose transport by English sparrow (Passer domesticus) skeletal muscle: have we been chirping up the wrong tree? | Journal of experimental zoology. Part A, Comparative experimental biology 20050201 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. | Diabetes 20050201 |
| Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. | Diabetes 20050201 |
| Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. | Endocrinology 20050101 |
| Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. | Diabetes 20050101 |
| Preparation of 5-amino-4-imidazole-N-succinocarboxamide ribotide, 5-amino-4-imidazole-N-succinocarboxamide riboside and succinyladenosine, compounds usable in diagnosis and research of adenylosuccinate lyase deficiency. | Journal of inherited metabolic disease 20050101 |
| Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents. | Nucleosides, nucleotides & nucleic acids 20050101 |
| AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. | Carcinogenesis 20041201 |
| Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. | The Biochemical journal 20041201 |
| Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. | Toxicological sciences : an official journal of the Society of Toxicology 20041201 |
| The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. | Diabetes 20041201 |
| AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. | The Journal of biological chemistry 20041112 |
| AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo. | American journal of physiology. Endocrinology and metabolism 20041101 |
| Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. | American journal of physiology. Endocrinology and metabolism 20041101 |
| Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. | Diabetologia 20041101 |
| AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20041001 |
| Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels. | Circulation research 20041001 |
| The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. | Arthritis and rheumatism 20041001 |
| Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. | Transplantation 20040915 |
| Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. | American journal of physiology. Endocrinology and metabolism 20040901 |
| AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females. | The Journal of clinical endocrinology and metabolism 20040901 |
| Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. | FEBS letters 20040827 |
| AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. | Biochemical and biophysical research communications 20040813 |
| Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. | Endocrinology 20040801 |
| Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. | American journal of physiology. Endocrinology and metabolism 20040801 |
| Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. | Diabetes 20040801 |
| Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. | The Journal of biological chemistry 20040730 |
| AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. | Circulation 20040727 |
| AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo. | Diabetes 20040701 |
| 5'-aminoimidazole-4-carboxyamide-ribonucleoside-activated glucose transport is not prevented by nitric oxide synthase inhibition in rat isolated skeletal muscle. | Clinical and experimental pharmacology & physiology 20040701 |
| Insulin-nonspecific reduction in skeletal muscle glucose transport in high-fat-fed rats. | Metabolism: clinical and experimental 20040701 |
| MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. | American journal of physiology. Cell physiology 20040601 |
| AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. | American journal of human genetics 20040601 |
| AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide. | Diabetes 20040601 |
| 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. | Biochemical and biophysical research communications 20040528 |
| Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. | Biochemical pharmacology 20040515 |
| C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. | The Journal of biological chemistry 20040507 |
| A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts. | Journal of molecular biology 20040507 |
| Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. | The Journal of biological chemistry 20040423 |
| Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. | The Journal of biological chemistry 20040416 |
| AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. | Biochemical and biophysical research communications 20040409 |
| Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates. | The Journal of biological chemistry 20040326 |
| Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). | The Biochemical journal 20040315 |
| Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. | Biochemistry 20040210 |
| Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle. | American journal of physiology. Endocrinology and metabolism 20040201 |
| 5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-kappaB in mouse Neuro 2a neuroblastoma cells. | Neuroscience letters 20040116 |
| Multiple independent kinase cascades are targeted by hyperosmotic stress but only one activates stress kinase p38. | Experimental cell research 20040115 |
| 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040114 |
| Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. | The Journal of biological chemistry 20040109 |
| Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose. | The Biochemical journal 20040101 |
| Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles. | Canadian journal of physiology and pharmacology 20031101 |
| Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes. | The Journal of biological chemistry 20031003 |
| Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients. | Diabetologia 20031001 |
| Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. | Journal of applied physiology (Bethesda, Md. : 1985) 20030901 |
| Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. | Endocrinology 20030901 |
| The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901 |
| Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. | The Journal of biological chemistry 20030822 |
| AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions. | The Journal of physiology 20030815 |
| AMP-activated protein kinase and muscle glucose uptake. | Acta physiologica Scandinavica 20030801 |
| AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. | Acta physiologica Scandinavica 20030801 |
| Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. | The Journal of biological chemistry 20030718 |
| Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. | Diabetes 20030701 |
| PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations. | American journal of physiology. Cell physiology 20030601 |
| Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. | American journal of physiology. Cell physiology 20030501 |
| Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. | Blood 20030501 |
| 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. | Diabetes 20030501 |
| [Physiological roles of AMP-activated protein kinase (AMPK)]. | Medecine sciences : M/S 20030501 |
| Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. | Journal of applied physiology (Bethesda, Md. : 1985) 20030401 |
| 5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms. | American journal of physiology. Regulatory, integrative and comparative physiology 20030401 |
| A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals. | Biochemical Society transactions 20030201 |
| Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'. | Biochemical Society transactions 20030201 |
| Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. | The Journal of biological chemistry 20030110 |
| Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase. | Diabetes 20030101 |
| A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. | Genes to cells : devoted to molecular & cellular mechanisms 20030101 |
| AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20021201 |
| ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. | FEBS letters 20021120 |
| Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. | FEBS letters 20021106 |
| AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20021101 |
| Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells. | American journal of physiology. Endocrinology and metabolism 20021101 |
| AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. | American journal of physiology. Endocrinology and metabolism 20021101 |
| Hemodynamic actions of acute ethanol after resuscitation from traumatic brain injury. | The Journal of trauma 20021101 |
| AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. | Diabetes 20021001 |
| Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. | FEBS letters 20020828 |
| Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. | Endocrinology 20020801 |
| Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. | European journal of biochemistry 20020801 |
| Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes. | NMR in biomedicine 20020801 |
| AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. | The Journal of biological chemistry 20020705 |
| Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. | Diabetes 20020701 |
| Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport. | The Journal of biological chemistry 20020628 |
| Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations. | Biochemical and biophysical research communications 20020621 |
| Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. | American journal of physiology. Endocrinology and metabolism 20020601 |
| Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle. | American journal of physiology. Endocrinology and metabolism 20020601 |
| Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). | Journal of cell science 20020601 |
| The fixM flavoprotein modulates inhibition by AICAR or 5'AMP of respiratory and nitrogen fixation gene expression in Sinorhizobium meliloti. | Molecular plant-microbe interactions : MPMI 20020601 |
| AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. | Biochemical and biophysical research communications 20020510 |
| Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+). | American journal of physiology. Endocrinology and metabolism 20020501 |
| A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. | Developmental biology 20020501 |
| Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. | Endocrinology 20020401 |
| An mRNA splice variant of the AFX gene with altered transcriptional activity. | The Journal of biological chemistry 20020308 |
| Effect of AICAR treatment on glycogen metabolism in skeletal muscle. | Diabetes 20020301 |
| Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). | The Biochemical journal 20020215 |
| Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. | The Journal of biological chemistry 20020208 |
| Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. | Diabetes 20020201 |
| 5-amino-4-imidazolecarboxamide riboside confers strong tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent fashion. | Biochemical and biophysical research communications 20020111 |
| Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. | Diabetes 20020101 |
| 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. | Diabetologia 20020101 |
| 5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice. | Diabetologia 20011201 |
| Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. | The Journal of biological chemistry 20011102 |
| AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4. | Journal of applied physiology (Bethesda, Md. : 1985) 20011101 |
| Role of AMP-activated protein kinase in mechanism of metformin action. | The Journal of clinical investigation 20011015 |
| Regulation of myocardial fatty acid oxidation by substrate supply. | American journal of physiology. Heart and circulatory physiology 20011001 |
| Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. | Biochemical and biophysical research communications 20010921 |
| The effects of AICAR on adipocyte differentiation of 3T3-L1 cells. | Biochemical and biophysical research communications 20010907 |
| Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. | Journal of applied physiology (Bethesda, Md. : 1985) 20010901 |
| Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. | American journal of physiology. Endocrinology and metabolism 20010801 |
| AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. | Journal of molecular neuroscience : MN 20010801 |
| Calculation of relative binding free energy differences for fructose 1,6-bisphosphatase inhibitors using the thermodynamic cycle perturbation approach. | Journal of the American Chemical Society 20010704 |
| Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. | Diabetes 20010701 |
| Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. | Circulation research 20010622 |
| Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway. | The Journal of biological chemistry 20010601 |
| Combination therapy that targets secondary pulmonary changes after abdominal trauma. | Shock (Augusta, Ga.) 20010601 |
| Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. | Diabetes 20010501 |
| Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro. | Biochemical and biophysical research communications 20010427 |
| Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase. | Biochemical and biophysical research communications 20010420 |
| Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. | The Biochemical journal 20010415 |
| Acute exposure to AICAR increases glucose transport in mouse EDL and soleus muscle. | Biochemical and biophysical research communications 20010413 |
| A purine-related metabolite negatively regulates fixNOQP expression in Sinorhizobium meliloti by modulation of fixK expression. | Molecular plant-microbe interactions : MPMI 20010401 |
| The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes. | FEBS letters 20010202 |
| Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. | Diabetes 20010101 |
| Nitrogen-dependent accumulation of cytokinins in root and the translocation to leaf: implication of cytokinin species that induces gene expression of maize response regulator. | Plant & cell physiology 20010101 |
| Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase. | Biochemistry 19990309 |
| AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. | The American journal of physiology 19971201 |
| 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? | European journal of biochemistry 19950415 |
| Carboxylases in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme. | Biochemistry 19941004 |
| N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. | Biochemistry 19940301 |
| Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes. | Molecular endocrinology (Baltimore, Md.) |