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Eprotirome

CAS No.:
355129-15-6
Catalog Number:
AG00C0VS
Molecular Formula:
C18H17Br2NO5
Molecular Weight:
487.1393
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$335
- +
Product Description
Catalog Number:
AG00C0VS
Chemical Name:
Eprotirome
CAS Number:
355129-15-6
Molecular Formula:
C18H17Br2NO5
Molecular Weight:
487.1393
MDL Number:
MFCD11045847
IUPAC Name:
3-[3,5-dibromo-4-(4-hydroxy-3-propan-2-ylphenoxy)anilino]-3-oxopropanoic acid
InChI:
InChI=1S/C18H17Br2NO5/c1-9(2)12-7-11(3-4-15(12)22)26-18-13(19)5-10(6-14(18)20)21-16(23)8-17(24)25/h3-7,9,22H,8H2,1-2H3,(H,21,23)(H,24,25)
InChI Key:
VPCSYAVXDAUHLT-UHFFFAOYSA-N
SMILES:
O=C(Nc1cc(Br)c(c(c1)Br)Oc1ccc(c(c1)C(C)C)O)CC(=O)O
UNII:
958AQ7B6R1
Properties
Complexity:
492  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
486.945g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
487.144g/mol
Monoisotopic Mass:
484.947g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
95.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5  
Literature
Title Journal
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorganic & medicinal chemistry 20120601
Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia. Core evidence 20120101
Familial hypercholesterolemia: present and future management. Current cardiology reports 20111201
Lipoprotein(a): medical treatment options for an elusive molecule. Current pharmaceutical design 20110101
Association between the interleukin-6 promoter polymorphism -174G/C and serum lipoprotein(a) concentrations in humans. PloS one 20110101
Lipid lowering with thyroid hormone and thyromimetics. Current opinion in lipidology 20101201
Lipoprotein(a) as a cardiovascular risk factor: current status. European heart journal 20101201
Thyroid hormones, mitochondrial bioenergetics and lipid handling. Current opinion in endocrinology, diabetes, and obesity 20101001
Thyroid hormone receptor and lipid regulation. Current opinion in investigational drugs (London, England : 2000) 20101001
Lipids: Eprotirome shows promise as a novel way to target dyslipidemia. Nature reviews. Endocrinology 20100701
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (London, England) 20100508
Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. The New England journal of medicine 20100311
Recent advances in preventing cardiovascular disorders by managing lipid levels. F1000 medicine reports 20100101
The resurgence of thyromimetics as lipid-modifying agents. Current opinion in investigational drugs (London, England : 2000) 20090901
Hotline sessions presented at the American College of Cardiology Congress 2009. Clinical research in cardiology : official journal of the German Cardiac Society 20090601
[Thyroid hormone analogs: an important biological supply and new therapeutic possibilities]. Annales d'endocrinologie 20080901
Selective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress. Expert opinion on investigational drugs 20080501
Properties