Home Other Building Blocks 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

CAS No.:
415697-08-4
Catalog Number:
AG00C0BQ
Molecular Formula:
C20H22N2O5S
Molecular Weight:
402.4641
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$251
- +
10mg
99%
1 week
United States
$418
- +
25mg
99%
1 week
United States
$807
- +
Product Description
Catalog Number:
AG00C0BQ
Chemical Name:
2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
CAS Number:
415697-08-4
Molecular Formula:
C20H22N2O5S
Molecular Weight:
402.4641
MDL Number:
MFCD06798326
IUPAC Name:
ethyl 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-1,3-thiazolidine-4-carboxylate
InChI:
InChI=1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
InChI Key:
ZVYIJXLMBWCGHP-UHFFFAOYSA-N
SMILES:
CCOC(=O)C1CSC(N1)Cc1ccc(cc1)OCc1ccc(cc1)[N+](=O)[O-]
Properties
Complexity:
513  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
402.125g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
402.465g/mol
Monoisotopic Mass:
402.125g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
119A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes. Neurochemistry international 20120501
High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. British journal of pharmacology 20120401
Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons. American journal of physiology. Regulatory, integrative and comparative physiology 20120401
Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels. Acta physiologica (Oxford, England) 20101101
The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Molecular pharmacology 20090901
A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets. Cell calcium 20090501
The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. Journal of neurophysiology 20090301
Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes. European journal of pharmacology 20071114
Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells. FEBS letters 20071002
Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells. Journal of pharmacological sciences 20070901
Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor. Annals of the New York Academy of Sciences 20070301
Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Annals of the New York Academy of Sciences 20070301
YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Molecular pharmacology 20061201
The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency. Experimental eye research 20061101
[Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. Clinical calcium 20040801
The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Molecular pharmacology 20040701
Properties