API-2
| Title | Journal |
|---|---|
| Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells. | Toxicology in vitro : an international journal published in association with BIBRA 20180301 |
| Why are most phospholipidosis inducers also hERG blockers? | Archives of toxicology 20171201 |
| Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway. | Toxicology letters 20150805 |
| Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression. | International journal of molecular medicine 20131001 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Inhibitory roles of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis. | Endocrinology 20130201 |
| Akt or phosphoinositide-3-kinase inhibition reverses cardio-protection in Toll-like receptor 2 deficient mice. | Resuscitation 20121101 |
| Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling. | Journal of molecular and cellular cardiology 20121001 |
| Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. | Cancer research 20120901 |
| The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. | Cancer discovery 20120701 |
| Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. | Translational research : the journal of laboratory and clinical medicine 20120601 |
| AKT inhibition by triciribine alone or as combination therapy for growth control of gastroenteropancreatic neuroendocrine tumors. | International journal of oncology 20120301 |
| Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells. | Toxicology 20120226 |
| FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. | PloS one 20120101 |
| IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. | The Journal of biological chemistry 20111028 |
| AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. | Biological psychiatry 20110915 |
| Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. | Stem cells and development 20110701 |
| JAM-A regulates epithelial proliferation through Akt/β-catenin signalling. | EMBO reports 20110401 |
| Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia. | Journal of cellular physiology 20110301 |
| Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. | Endocrinology 20110201 |
| 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells. | The Prostate 20101101 |
| Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef. | Antimicrobial agents and chemotherapy 20100401 |
| Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin: similarities with a model of endogenous hyperleptinemia. | Endocrinology 20100301 |
| Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle. | Molecular and cellular endocrinology 20100205 |
| Chronic hyperleptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin. | Peptides 20100101 |
| A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. | PloS one 20100101 |
| 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway. | Chemical research in toxicology 20091201 |
| Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. | European journal of obstetrics, gynecology, and reproductive biology 20090901 |
| The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. | International journal of cancer 20090815 |
| Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D. | Gene therapy 20090401 |
| [Akt enzyme: new therapeutic target in cancer and diabetes?]. | Orvosi hetilap 20090222 |
| High-throughput screening compatible cell-based assay for interrogating activated notch signaling. | Assay and drug development technologies 20090201 |
| Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. | The Biochemical journal 20090101 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells. | Journal of cellular physiology 20081101 |
| The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. | Bioorganic & medicinal chemistry 20080901 |
| Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB. | Neuropeptides 20080601 |
| MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. | Cancer research 20080115 |
| Resistin, an adipocytokine, offers protection against acute myocardial infarction. | Journal of molecular and cellular cardiology 20071101 |
| Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. | Clinical cancer research : an official journal of the American Association for Cancer Research 20071001 |
| Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines. | Biochemical and biophysical research communications 20060210 |
| Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer. | Current opinion in investigational drugs (London, England : 2000) 20051201 |
| Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine. | Journal of medicinal chemistry 20050602 |
| Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents. | Bioorganic & medicinal chemistry letters 20040705 |
| An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. | Nucleosides, nucleotides & nucleic acids 20040101 |
| Synthesis and antiviral activity of 2-substituted analogs of triciribine. | Nucleosides, nucleotides & nucleic acids 20031201 |
| Synthesis of carbocyclic analogs of 2',3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin, and 2',3'-dideoxytriciribine. | Nucleosides, nucleotides & nucleic acids 20010101 |
| Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation. | Journal of medicinal chemistry 20000615 |
| Phosphorylation of triciribine is necessary for activity against HIV type 1. | AIDS research and human retroviruses 19981010 |
| Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. | AIDS research and human retroviruses 19930401 |
| Dual mechanisms of inhibition of DNA synthesis by triciribine. | Cancer research 19900815 |