Home Other Building Blocks DESMOSTEROL

DESMOSTEROL

CAS No.:
313-04-2
Catalog Number:
AG00BZJX
Molecular Formula:
C27H44O
Molecular Weight:
384.6377
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$96
- +
5mg
≥98%
1 week
United States
$135
- +
10mg
≥98%
1 week
United States
$193
- +
25mg
≥98%
1 week
United States
$348
- +
Product Description
Catalog Number:
AG00BZJX
Chemical Name:
DESMOSTEROL
CAS Number:
313-04-2
Molecular Formula:
C27H44O
Molecular Weight:
384.6377
MDL Number:
MFCD00056432
IUPAC Name:
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChI:
InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI Key:
AVSXSVCZWQODGV-DPAQBDIFSA-N
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC=C(C)C)C)C)C1)C
EC Number:
206-236-2
UNII:
ANP93865R8
Properties
Complexity:
641  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
384.339g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
384.648g/mol
Monoisotopic Mass:
384.339g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
20.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8.3  
Literature
Title Journal
Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. Toxicology in vitro : an international journal published in association with BIBRA 20160401
Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. The Journal of biological chemistry 20151016
E2012-induced cataract and its predictive biomarkers. Toxicological sciences : an official journal of the Society of Toxicology 20140101
Alzheimer's disease: brain desmosterol levels. Journal of Alzheimer's disease : JAD 20130101
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. Journal of lipid research 20121101
Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. Clinical chemistry 20121101
Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice. Brain research 20121022
Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20121001
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 20120928
The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochimica et biophysica acta 20120901
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. Molecular neurobiology 20120801
A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. Journal of lipid research 20120701
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorganic & medicinal chemistry 20120701
Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell metabolism 20120502
Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. Journal of the American Chemical Society 20120425
Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. Biophysical journal 20120404
Inorganic nitrogen, sterols and bacterial source tracking as tools to characterize water quality and possible contamination sources in surface water. Water research 20120315
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. Cell death and differentiation 20120301
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Brain imaging and behavior 20120301
Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biology of reproduction 20120301
Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. Journal of lipid research 20120301
The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum. Journal of molecular endocrinology 20120201
Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. Current eye research 20120201
Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. Journal of atherosclerosis and thrombosis 20120101
Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. Experimental diabetes research 20120101
Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacognosy magazine 20120101
Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PloS one 20120101
Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. International journal of Alzheimer's disease 20120101
Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Current gerontology and geriatrics research 20120101
A highly specific and sensitive quantification analysis of the sterols in silkworm larvae by high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Analytical biochemistry 20111215
Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215
Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. Biochimica et biophysica acta 20111201
Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. Atherosclerosis 20111201
Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry. Integrative zoology 20111201
Chance and serendipity in science: two examples from my own career. The Journal of biological chemistry 20111104
Biosynthesis of cholesterol and other sterols. Chemical reviews 20111012
Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? Biochimica et biophysica acta 20111001
Membrane cholesterol as a mediator of the neuroprotective effects of estrogens. Neuroscience 20110915
The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter. European journal of human genetics : EJHG 20110901
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS genetics 20110901
Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. American journal of medical genetics. Part A 20110701
Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. Plant foods for human nutrition (Dordrecht, Netherlands) 20110601
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of lipid research 20110301
Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. Current pharmaceutical biotechnology 20110201
Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women. Genes & nutrition 20110201
HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C. Clinica chimica acta; international journal of clinical chemistry 20110114
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. Journal of hepatology 20110101
Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study. Lipids in health and disease 20110101
Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. Lipids in health and disease 20110101
Lipid pathway alterations in Parkinson's disease primary visual cortex. PloS one 20110101
The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. Journal of clinical lipidology 20110101
Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. Journal of nutrition and metabolism 20110101
Sterol composition in larvae of the silkworm, Bombyx mori. Bioscience, biotechnology, and biochemistry 20110101
Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders. Dermato-endocrinology 20110101
Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf. Pharmacognosy magazine 20110101
Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori. PloS one 20110101
The role of soluble fiber intake in patients under highly effective lipid-lowering therapy. Nutrition journal 20110101
Bioactivities from marine algae of the genus Gracilaria. International journal of molecular sciences 20110101
Molecular basis for certain neuroprotective effects of thyroid hormone. Frontiers in molecular neuroscience 20110101
Enteric microbiome metabolites correlate with response to simvastatin treatment. PloS one 20110101
Genome characterization of the oleaginous fungus Mortierella alpina. PloS one 20110101
The ELBA force field for coarse-grain modeling of lipid membranes. PloS one 20110101
Statins: past and present. Heart views : the official journal of the Gulf Heart Association 20110101
Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. Asian journal of andrology 20101101
Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. The Journal of steroid biochemistry and molecular biology 20101101
The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. IUBMB life 20101101
Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin. Journal of cardiovascular pharmacology 20101001
Subcellular organelle lipidomics in TLR-4-activated macrophages. Journal of lipid research 20100901
New insights into the molecular mechanisms of general anaesthetics. British journal of pharmacology 20100901
Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. The Journal of steroid biochemistry and molecular biology 20100801
Alterations of cholesterol precursor levels in Alzheimer's disease. Biochimica et biophysica acta 20100801
Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100801
Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801
Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy. Atherosclerosis 20100701
Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. International journal of andrology 20100601
Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men. Nutrition, metabolism, and cardiovascular diseases : NMCD 20100601
Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. Metabolism: clinical and experimental 20100601
A historical perspective on the discovery of statins. Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511
Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. Atherosclerosis 20100501
Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. Animal reproduction science 20100401
Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes 20100201
Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. Journal of lipid research 20100101
Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. Arteriosclerosis, thrombosis, and vascular biology 20100101
Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. Journal of neurochemistry 20100101
Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. Journal of Alzheimer's disease : JAD 20100101
Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. Lipids in health and disease 20100101
Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes. PloS one 20100101
Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain. BMC medical genomics 20100101
A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. PloS one 20100101
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Molecular systems biology 20100101
The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle. PloS one 20100101
Perspective on plasma membrane cholesterol efflux and spermatozoal function. Journal of human reproductive sciences 20100101
Sterols from the Madagascar sponge Fascaplysinopsis sp. Marine drugs 20100101
Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study. Nutrition, metabolism, and cardiovascular diseases : NMCD 20091001
Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. Biochimica et biophysica acta 20091001
Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. Journal of lipid research 20090901
Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715
[Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. Postepy higieny i medycyny doswiadczalnej (Online) 20090713
New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. Frontiers in neuroendocrinology 20090701
Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. The American Journal of dermatopathology 20090701
Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. The British journal of nutrition 20090601
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. Neurochemical research 20090601
Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. Journal of diabetes 20090601
Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. The Biochemical journal 20090513
How essential is cholesterol? The Biochemical journal 20090513
High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. Journal of andrology 20090101
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). Neurochemical research 20090101
Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? Pediatric rheumatology online journal 20090101
Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. Biochemical and biophysical research communications 20081212
Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. Journal of inherited metabolic disease 20081201
Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. Journal of molecular endocrinology 20081101
Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. The Journal of chemical physics 20081021
Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 20081001
Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. Pharmacogenetics and genomics 20081001
Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. Endocrinology 20080901
Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. Steroids 20080801
Discovering oxysterols in plasma: a window on the metabolome. Journal of proteome research 20080801
Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1. Neuropsychiatric disease and treatment 20080801
Cholesterol substitution increases the structural heterogeneity of caveolae. The Journal of biological chemistry 20080523
Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. Biochemistry 20080520
SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080501
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401
Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. The British journal of dermatology 20080401
Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20080105
Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. Atherosclerosis 20080101
Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. Current medical research and opinion 20080101
Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. BMC systems biology 20080101
Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Reproductive biology and endocrinology : RB&E 20080101
Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic (Copenhagen, Denmark) 20071101
Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. Arteriosclerosis, thrombosis, and vascular biology 20071001
The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. Atherosclerosis 20070901
Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. Hepatology (Baltimore, Md.) 20070901
Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. Journal of structural biology 20070801
Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. Clinica chimica acta; international journal of clinical chemistry 20070801
Seasonal and geographical variations of sterol composition in snow crab hepatopancreas and pelagic fish viscera from Eastern Quebec. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20070701
Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Molecular genetics and metabolism 20070501
Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Analytica chimica acta 20070404
Assessing the nature of lipid raft membranes. PLoS computational biology 20070201
[Factors modulating parameters of cholesterol homeostasis in the metabolic syndrome]. Casopis lekaru ceskych 20070101
Quantifying raft proteins in neonatal mouse brain by 'tube-gel' protein digestion label-free shotgun proteomics. Proteome science 20070101
Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption. Clinica chimica acta; international journal of clinical chemistry 20061201
Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. Atherosclerosis 20061001
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of biological chemistry 20060922
Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060914
Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. The Journal of biological chemistry 20060804
Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. Experimental cell research 20060801
Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells. Biochemical and biophysical research communications 20060630
DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 20060601
HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. Lipids 20060601
Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. Biophysical journal 20060501
DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis. The Journal of investigative dermatology 20060301
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. The Journal of biological chemistry 20060217
Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. Transplantation 20060215
Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. Neuroreport 20060206
Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. The Journal of pediatrics 20060201
Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. The Journal of biological chemistry 20060106
Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease. Menopause (New York, N.Y.) 20060101
Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. Rapid communications in mass spectrometry : RCM 20060101
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. Journal of neurochemistry 20051101
Recent insights into the Smith-Lemli-Opitz syndrome. Clinical genetics 20051101
Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit. Prenatal diagnosis 20051101
Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. Biophysical journal 20051001
Reductions in cholesterol and synaptic markers in association cortex in mood disorders. Bipolar disorders 20051001
Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation. Cryobiology 20050801
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. Molecular endocrinology (Baltimore, Md.) 20050701
A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study. Chemistry and physics of lipids 20050701
Lipid composition of deep-sea hydrothermal vent tubeworm Riftia pachyptila, crabs Munidopsis subsquamosa and Bythograea thermydron, mussels Bathymodiolus sp. and limpets Lepetodrilus spp. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20050601
Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. Analytical and bioanalytical chemistry 20050401
Desmosterol may replace cholesterol in lipid membranes. Biophysical journal 20050301
[Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20041201
Secretion of sterols and the NPC2 protein from primary astrocytes. The Journal of biological chemistry 20041119
Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. Cryobiology 20041001
Oxysteroids: a new class of steroids with autocrine and paracrine functions. Trends in endocrinology and metabolism: TEM 20041001
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. Journal of lipid research 20040901
An HPLC method for the quantification of sterols in edible seaweeds. Biomedical chromatography : BMC 20040401
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. Journal of lipid research 20040301
Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. The Journal of clinical endocrinology and metabolism 20040301
Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. Journal of chemical ecology 20040301
Effectiveness of twenty, twenty-five diazacholesterol, avian gonadotropin-releasing hormone, and chicken riboflavin carrier protein for inhibiting reproduction in Coturnix quail. Poultry science 20040201
Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC developmental biology 20040101
Reactive oxygen species and sperm cells. Reproductive biology and endocrinology : RB&E 20040101
Generation of viable cholesterol-free mice. Science (New York, N.Y.) 20031219
Novel sterols synthesized via the CYP27A1 metabolic pathway. Archives of biochemistry and biophysics 20031201
Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. European journal of clinical investigation 20031101
Formal synthesis of squalamine from desmosterol. Chemical & pharmaceutical bulletin 20031001
Decrease in order of human sperm lipids during capacitation. Biology of reproduction 20030801
Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. The Journal of biological chemistry 20030530
Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. Journal of lipid research 20030401
Structural features of sterols required to inhibit human sperm capacitation. Biology of reproduction 20030401
Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Molecular and cellular biology 20030201
On the role of liver X receptors in lipid accumulation in adipocytes. Molecular endocrinology (Baltimore, Md.) 20030201
First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids 20030201
Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. Neurobiology of aging 20030101
Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. Journal of agricultural and food chemistry 20030101
Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. American journal of medical genetics 20021215
Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism: clinical and experimental 20021201
Specificity of the commonly used enzymatic assay for plasma cholesterol determination. Journal of clinical pathology 20021101
Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. Atherosclerosis 20020901
Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. The Biochemical journal 20020815
Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. Journal of lipid research 20020801
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. Journal of lipid research 20020701
Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). Lipids 20020601
Influence of simvastatin, pravastatin, and BM 15.766 on neutral sterols in liver and testis of guinea pigs. Metabolism: clinical and experimental 20020401
Interannual and between species comparison of the lipids, fatty acids and sterols of Antarctic krill from the US AMLR Elephant Island survey area. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20020401
Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. Journal of lipid research 20020301
Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet. The British journal of nutrition 20020301
Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes. Clinica chimica acta; international journal of clinical chemistry 20020201
[Synthesis of C24-functionalized hydroxysterols]. Bioorganicheskaia khimiia 20020101
Short-term LDL cholesterol-lowering efficacy of plant stanol esters. BMC cardiovascular disorders 20020101
Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study. Pediatric research 20011201
Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. Journal of chromatography. A 20011123
Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. American journal of human genetics 20011001
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Leukemia 20010901
Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. Journal of lipid research 20010701
Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus. Journal of chemical ecology 20010601
Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. Biochimica et biophysica acta 20010402
Interannual variations in the lipids of the Antarctic pteropods Clione limacina and Clio pyramidata. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010301
Progestins block cholesterol synthesis to produce meiosis-activating sterols. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301
Clofibrate-induced myotonia in the rat. Experientia 19781215
[Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. Annales pharmaceutiques francaises 19721201
Properties