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Picroside II

CAS No.:
39012-20-9
Catalog Number:
AG00BYG2
Molecular Formula:
C23H28O13
Molecular Weight:
512.4606
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Product Description
Catalog Number:
AG00BYG2
Chemical Name:
Picroside II
CAS Number:
39012-20-9
Molecular Formula:
C23H28O13
Molecular Weight:
512.4606
MDL Number:
MFCD00135962
IUPAC Name:
[2-(hydroxymethyl)-10-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-5-yl] 4-hydroxy-3-methoxybenzoate
InChI:
InChI=1S/C23H28O13/c1-31-12-6-9(2-3-11(12)26)20(30)34-18-10-4-5-32-21(14(10)23(8-25)19(18)36-23)35-22-17(29)16(28)15(27)13(7-24)33-22/h2-6,10,13-19,21-22,24-29H,7-8H2,1H3/t10?,13-,14?,15-,16+,17-,18?,19?,21?,22+,23?/m1/s1
InChI Key:
AKNILCMFRRDTEY-MRFBWRKESA-N
SMILES:
OCC1OC(OC2OC=CC3C2C2(CO)OC2C3OC(=O)c2ccc(c(c2)OC)O)C(C(C1O)O)O
EC Number:
254-247-6
Properties
Complexity:
839  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
512.153g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
512.464g/mol
Monoisotopic Mass:
512.153g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
197A^2
Undefined Atom Stereocenter Count:
6  
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.4  
Literature
Title Journal
The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes. Pharmaceutical biology 20121001
Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways. International journal of molecular medicine 20120801
TLC densitometric quantification of picrosides (picroside-I and picroside-II) in Picrorhiza kurroa and its substitute Picrorhiza scrophulariiflora and their antioxidant studies. Biomedical chromatography : BMC 20120101
Primary study for the therapeutic dose and time window of picroside II in treating cerebral ischemic injury in rats. International journal of molecular sciences 20120101
Assessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs. Xenobiotica; the fate of foreign compounds in biological systems 20110701
Online HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry. Indian journal of experimental biology 20100301
Anti-inflammation effects of picroside 2 in cerebral ischemic injury rats. Behavioral and brain functions : BBF 20100101
Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. International journal of molecular sciences 20100101
Simultaneous determination of sugars and picrosides in Picrorhiza species using ultrasonic extraction and high-performance liquid chromatography with evaporative light scattering detection. Journal of chromatography. A 20080620
A sensitive and selective RP-HPLC method for simultaneous determination of picroside-I and picroside-II in rat plasma and its application in pharmacokinetics studies. Journal of separation science 20071001
The neuroprotective effect of picroside II from hu-huang-lian against oxidative stress. The American journal of Chinese medicine 20070101
Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2. Pharmacological reports : PR 20070101
Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. World journal of gastroenterology 20050628
Inhibitory effect of picroside II on hepatocyte apoptosis. Acta pharmacologica Sinica 20050601
Determination of picroside II in dog plasma by HPLC and its application in a pharmacokinetics study. Biomedical chromatography : BMC 20050501
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life sciences 20020830
Properties