Home Other Building Blocks MECLIZINE HYDROCHLORIDE (500 MG)

MECLIZINE HYDROCHLORIDE (500 MG)

CAS No.:
31884-77-2
Catalog Number:
AG00BY2Z
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%(HPLC)
In Stock USA
United States
$47
- +
25mg
98%(HPLC)
In Stock USA
United States
$84
- +
100mg
98%(HPLC)
In Stock USA
United States
$156
- +
Product Description
Catalog Number:
AG00BY2Z
Chemical Name:
MECLIZINE HYDROCHLORIDE (500 MG)
CAS Number:
31884-77-2
MDL Number:
MFCD00941489
IUPAC Name:
1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride
InChI:
InChI=1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2
InChI Key:
KDLHYOMCWBWLMM-UHFFFAOYSA-N
Properties
Complexity:
448  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
4  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
480.15g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
481.886g/mol
Monoisotopic Mass:
480.15g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
7.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochemical pharmacology 20151001
Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs. Pakistan journal of pharmaceutical sciences 20120101
Pharmaceutical countermeasures have opposite effects on the utricles and semicircular canals in man. Audiology & neuro-otology 20120101
No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20110401
Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. The Journal of pharmacology and experimental therapeutics 20110301
Helix 11 dynamics is critical for constitutive androstane receptor activity. Structure (London, England : 1993) 20110112
Quantification of meclizine in human plasma by high performance liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110101
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nature biotechnology 20100301
Biphasic dosing regimen of meclizine for prevention of postoperative nausea and vomiting in a high-risk population. AANA journal 20100201
Withdrawal symptoms after discontinuation of transdermal scopolamine therapy: treatment with meclizine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091115
Vertigo - part 2 - management in general practice. Australian family physician 20080601
Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070601
Spectrophotometric methods for the simultaneous analysis of meclezine hydrochloride and pyridoxine hydrochloride in bulk drug and pharmaceutical formulations. Pakistan journal of pharmaceutical sciences 20070401
Airsickness prevention in helicopter passengers. Aviation, space, and environmental medicine 20070401
Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. AANA journal 20070201
Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug metabolism reviews 20060101
Motion-sickness medications for aircrew: impact on psychomotor performance. Aviation, space, and environmental medicine 20050601
Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime. The Annals of pharmacotherapy 20041101
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Molecular endocrinology (Baltimore, Md.) 20041001
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20040901
The successful use of meclizine in panic disorder. The Journal of clinical psychiatry 20040901
Effects of drug countermeasures for space motion sickness on working memory in humans. Neurotoxicology and teratology 20040101
Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis. Analytical and bioanalytical chemistry 20030701
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. European journal of pharmacology 20030221
Delivery outcome after the use of meclozine in early pregnancy. European journal of epidemiology 20030101
Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiological genomics 20021029
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis 20020415
Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010501
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 20010101
Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201
Development of urinary retention during treatment with clozapine and meclizine. The American journal of psychiatry 19940401
Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. Journal of clinical pharmacology 19921101
Memory loss, confusion, and disorientation in an elderly woman taking meclizine. Journal of the American Geriatrics Society 19870501
Drug-induced extrapyramidal signs in chronic liver disease--a case report. Clinical toxicology 19770101
Properties