4-HYDROPEROXY CYCLOPHOSPHAMIDE
Title | Journal |
---|---|
Effects of four chemotherapeutic agents, bleomycin, etoposide, cisplatin, and cyclophosphamide, on DNA damage and telomeres in a mouse spermatogonial cell line. | Biology of reproduction 20140401 |
Methylated chrysin reduced cell proliferation, but antagonized cytotoxicity of other anticancer drugs in acute lymphoblastic leukemia. | Anti-cancer drugs 20120401 |
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. | Chemico-biological interactions 20120105 |
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. | PloS one 20120101 |
Teratogen responsive signaling pathways in organogenesis stage mouse limbs. | Reproductive toxicology (Elmsford, N.Y.) 20090401 |
Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065. | Fertility and sterility 20090101 |
The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide. | Current cancer drug targets 20080501 |
4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. | Cell death and differentiation 20080201 |
Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay. | Cytometry. Part B, Clinical cytometry 20070701 |
Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. | Toxicological sciences : an official journal of the Society of Toxicology 20070701 |
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. | Investigational new drugs 20070201 |
RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. | Cancer chemotherapy and pharmacology 20070101 |
Teratogen-induced activation of p53 in early postimplantation mouse embryos. | Toxicological sciences : an official journal of the Society of Toxicology 20070101 |
Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells. | Experimental hematology 20061101 |
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation. | Journal of medicinal chemistry 20060713 |
Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries. | Toxicological sciences : an official journal of the Society of Toxicology 20060401 |
Cyclophosphamide enhances TNF-alpha-induced apoptotic cell death in murine vascular endothelial cell. | FEBS letters 20060306 |
Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer. | Anti-cancer drugs 20050701 |
Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde. | The Journal of pharmacology and experimental therapeutics 20050101 |
Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide. | Free radical biology & medicine 20040915 |
Alterations in gene expression induced in day-9 mouse embryos exposed to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP): analysis using cDNA microarrays. | Toxicological sciences : an official journal of the Society of Toxicology 20040601 |
Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040115 |
Teratogen-induced activation of caspase-6 and caspase-7 in early postimplantation mouse embryos. | Cell biology and toxicology 20030801 |
4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20030301 |
Teratogen-induced activation of the mitochondrial apoptotic pathway in the yolk sac of day 9 mouse embryos. | Birth defects research. Part A, Clinical and molecular teratology 20030201 |
Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35. | Cancer research 20021201 |
Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. | Cancer research 20021201 |
Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2). | Biochemical pharmacology 20021015 |
Kinetic analysis of the reactions of 4-hydroperoxycyclophosphamide and acrolein with glutathione, mesna, and WR-1065. | Drug metabolism and disposition: the biological fate of chemicals 20020801 |
Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. | Toxicology and applied pharmacology 20020601 |
Autologous bone marrow transplantation with 4-hydroperoxycyclophosphamide purging for acute myeloid leukaemia beyond first remission: a 10-year experience. | British journal of haematology 20020601 |
Purging in autologous hematopoietic stem cell transplantation using adenosine triphosphate (ATP) and 4-hydroperoxycyclophosphamide (4-HC). | Leukemia research 20020501 |
Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines. | Cancer treatment and research 20020101 |
Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. | Teratology 20011201 |
DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. | Clinical cancer research : an official journal of the American Association for Cancer Research 20011101 |
L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model. | Neurosurgery 20010201 |
Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene. | Molecular therapy : the journal of the American Society of Gene Therapy 20010101 |
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. | Cancer research 20001001 |
De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality. | The Journal of biological chemistry 19960517 |
Immediate hypersensitivity reaction to cyclophosphamide. | Arthritis and rheumatism 19940701 |
Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis. | Cancer research 19921115 |
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds. | European journal of cancer 19810601 |