(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol
| Title | Journal |
|---|---|
| Efficient stabilization of phosphodiester (PO), phosphorothioate (PS), and 2'-O-methoxy (2'-OMe) DNA·RNA hybrid duplexes by amino sugars. | Biochemistry 20120710 |
| Synthesis and antibacterial activity of novel neamine derivatives: preponderant role of the substituent position on the neamine core. | Organic & biomolecular chemistry 20120628 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Nature chemical biology 20111009 |
| Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond. | Bioorganic & medicinal chemistry letters 20110815 |
| Understanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal A-site. | PLoS computational biology 20110701 |
| The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative? | Biochimica et biophysica acta 20110601 |
| Influence of charge and structure on the coordination chemistry of copper aminoglycosides. | Dalton transactions (Cambridge, England : 2003) 20110227 |
| Identification of ligands for the Tau exon 10 splicing regulatory element RNA by using dynamic combinatorial chemistry. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110207 |
| Biosynthesis of ribostamycin derivatives by reconstitution and heterologous expression of required gene sets. | Applied biochemistry and biotechnology 20110201 |
| NMR and amber analysis of the neamine pharmacophore for the design of novel aminoglycoside antibiotics. | Bioorganic chemistry 20110201 |
| Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains. | Bioorganic & medicinal chemistry 20110101 |
| Neamine inhibits cell proliferation, migration, and invasion in H7402 human hepatoma cells. | Saudi medical journal 20101201 |
| Aminoglycoside binding to Oxytricha nova telomeric DNA. | Biochemistry 20101116 |
| Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity. | Journal of medicinal chemistry 20100513 |
| Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. | Biochemistry 20100309 |
| The nebramycin aminoglycoside profiles of Streptomyces tenebrarius and their characterization using an integrated liquid chromatography-electrospray ionization-tandem mass spectrometric analysis. | Analytica chimica acta 20100219 |
| Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. | Bioorganic & medicinal chemistry 20100215 |
| Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. | Journal of medicinal chemistry 20100114 |
| Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. | PloS one 20100101 |
| Synthesis and transfection properties of a series of lipidic neamine derivatives. | Bioconjugate chemistry 20091101 |
| Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations. | Organic & biomolecular chemistry 20091021 |
| Enantioseparation by MEKC using a ligand exchange-based chiral pseudostationary phase. | Electrophoresis 20090801 |
| Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. | Bioorganic & medicinal chemistry letters 20090415 |
| Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090315 |
| Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoring. | Journal of chemical information and modeling 20090201 |
| Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine. | Analytical and bioanalytical chemistry 20090101 |
| Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. | Chemistry (Weinheim an der Bergstrasse, Germany) 20090101 |
| Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics. | Perspectives in medicinal chemistry 20090101 |
| Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. | Biochemistry 20081202 |
| Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. | Bioorganic & medicinal chemistry letters 20081015 |
| Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. | Journal of the American Chemical Society 20080820 |
| Identification of tobramycin impurities for quality control process monitoring using high-performance anion-exchange chromatography with integrated pulsed amperometric detection. | Journal of pharmaceutical and biomedical analysis 20080805 |
| Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography. | Journal of chromatography. A 20080328 |
| Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption. | The Journal of antibiotics 20080201 |
| Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. | Biopolymers 20080101 |
| Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. | The FEBS journal 20071201 |
| Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA. | Organic letters 20071025 |
| Design and synthesis of a structurally constrained aminoglycoside. | The Journal of organic chemistry 20070706 |
| Unique O-ribosylation in the biosynthesis of butirosin. | Bioorganic & medicinal chemistry 20070701 |
| Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. | Bioorganic & medicinal chemistry 20070601 |
| Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. | Bioorganic & medicinal chemistry 20070601 |
| Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery. | Journal of the American Chemical Society 20070321 |
| Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. | Chembiochem : a European journal of chemical biology 20070212 |
| Determination of neomycin sulfate and impurities using high-performance anion-exchange chromatography with integrated pulsed amperometric detection. | Journal of pharmaceutical and biomedical analysis 20070104 |
| Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. | Oligonucleotides 20070101 |
| Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. | Nucleic acids symposium series (2004) 20070101 |
| Synthesis and antibacterial activity of novel neamine derivatives. | Bioorganic & medicinal chemistry letters 20061215 |
| Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. | Bioorganic & medicinal chemistry letters 20061001 |
| Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies. | Journal of medicinal chemistry 20060907 |
| A molecular dynamics simulation study of an aminoglycoside/A-site RNA complex: conformational and hydration patterns. | Biochimie 20060801 |
| Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides. | The FEBS journal 20060701 |
| Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat. | Bioorganic & medicinal chemistry 20060415 |
| Determination of tobramycin and impurities using high-performance anion exchange chromatography with integrated pulsed amperometric detection. | Journal of pharmaceutical and biomedical analysis 20060303 |
| Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. | Chemistry & biology 20060201 |
| Cationic polyamines inhibit anthrax lethal factor protease. | BMC pharmacology 20060101 |
| Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051215 |
| The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides. | Bioorganic & medicinal chemistry letters 20051115 |
| Neamine dimers targeting the HIV-1 TAR RNA. | Bioorganic & medicinal chemistry letters 20051101 |
| The RNA-bound conformation of neamine as determined by transferred NOE experiments. | Chembiochem : a European journal of chemical biology 20050701 |
| Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. | Bioorganic & medicinal chemistry letters 20050415 |
| Structure-activity relationships of aminoglycoside-arginine conjugates that bind HIV-1 RNAs as determined by fluorescence and NMR spectroscopy. | FEBS letters 20041119 |
| Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands. | Journal of the American Chemical Society 20041006 |
| A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. | Journal of medicinal chemistry 20040923 |
| Disaccharide mimetics of the aminoglycoside antibiotic neamine. | Chembiochem : a European journal of chemical biology 20040906 |
| Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics. | Pflugers Archiv : European journal of physiology 20040501 |
| Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. | Biochemistry 20040309 |
| Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues. | Organic letters 20040219 |
| Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step. | Antiviral research 20031101 |
| Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide. | Journal of molecular biology 20030227 |
| Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. | Chemistry & biology 20020601 |
| Design of novel antibiotics that bind to the ribosomal acyltransfer site. | Journal of the American Chemical Society 20020403 |
| An efficient synthesis of mimetics of neamine for RNA recognition. | Organic letters 20010531 |
| Study of aminoglycoside-nucleic acid interactions by an HPLC method. | Bioorganic & medicinal chemistry letters 20010423 |
| Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. | Bioorganic & medicinal chemistry letters 20010226 |
| Which aminoglycoside ring is most important for binding? A hydropathic analysis of gentamicin, paromomycin, and analogues. | Bioorganic & medicinal chemistry letters 20010122 |
| Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element. | Nucleosides, nucleotides & nucleic acids 20000101 |
| Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. | Cell 19930924 |
| Screening for new compounds with antiherpes activity. | Antiviral research 19841001 |