Home Other Building Blocks B-HT 920 DIHYDROCHLORIDE

B-HT 920 DIHYDROCHLORIDE

CAS No.:
36085-73-1
Catalog Number:
AG00BXDS
Molecular Formula:
C10H17Cl2N3S
Molecular Weight:
282.2331
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥95%
1 week
United States
$133
- +
10mg
≥95%
1 week
United States
$194
- +
50mg
≥95%
1 week
United States
$630
- +
100mg
99%
1 week
United States
$1107
- +
Product Description
Catalog Number:
AG00BXDS
Chemical Name:
B-HT 920 DIHYDROCHLORIDE
CAS Number:
36085-73-1
Molecular Formula:
C10H17Cl2N3S
Molecular Weight:
282.2331
MDL Number:
MFCD00274573
IUPAC Name:
6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride
InChI:
InChI=1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H
InChI Key:
DPQAXNSOFFYKDS-UHFFFAOYSA-N
SMILES:
C=CCN1CCc2c(CC1)nc(s2)N.Cl.Cl
UNII:
9R6E1D8H1O
Properties
Complexity:
210  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
281.052g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
282.227g/mol
Monoisotopic Mass:
281.052g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
70.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells. Neurotoxicology 20101201
[Dopaminergic neuroprotection and reconstruction of neural network tiara]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001
Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa). Journal of clinical pharmacy and therapeutics 20090601
Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report. European journal of neurology 20090201
Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells. European journal of pharmacology 20081119
The frequency of cardiac valvular regurgitation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20080515
Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Movement disorders : official journal of the Movement Disorder Society 20080430
Mechanism of decongestant activity of alpha 2-adrenoceptor agonists. Pulmonary pharmacology & therapeutics 20080101
Pharmacological modulation of dopaminergic brain activity and its reflection in spectral frequencies of the rat electropharmacogram. Neuropsychobiology 20080101
alpha2-adrenoceptor agonists as nasal decongestants. Pulmonary pharmacology & therapeutics 20070101
Pre-junctional alpha2-adrenoceptors modulation of the nitrergic transmission in the pig urinary bladder neck. Neurourology and urodynamics 20070101
Antagonistic activity of ascorbic acid (vitamin C) on dopaminergic modulation: apomorphine-induced stereotypic behavior in mice. Pharmacology 20060101
Immunohistochemical and functional evidence for a noradrenergic regulation in the horse penile deep dorsal vein. International journal of impotence research 20041201
Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca. European journal of pharmacology 20040405
Effects of an alpha2-adrenoceptor agonist in nasal mucosa. Archives of physiology and biochemistry 20031001
Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area. Neuroscience letters 20030821
Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neuroscience research 20030801
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. The Journal of pharmacology and experimental therapeutics 20030401
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries. Fundamental & clinical pharmacology 20020801
Impaired endothelial alpha-2 adrenergic receptor-mediated vascular relaxation in the fructose-fed rat. Hypertension research : official journal of the Japanese Society of Hypertension 20020301
Influence of sildenafil on central dopamine-mediated behaviour in male rats. Life sciences 20020215
alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. British journal of pharmacology 20011001
Identification of the dopamine autoreceptor in the guinea-pig retina as D(2) receptor using novel subtype-selective antagonists. British journal of pharmacology 20010801
Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. Biochemical pharmacology 20010501
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. European journal of pharmacology 20010406
Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein. European journal of pharmacology 20010216
Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells. Journal of pharmacological and toxicological methods 20010101
Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the cat. American journal of rhinology 20010101
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. British journal of pharmacology 20000401
Talipexole protects dopaminergic neurons from methamphetamine toxicity in C57BL/6N mouse. Neuroscience letters 19980515
Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats. Methods and findings in experimental and clinical pharmacology 19970901
Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland. The Journal of pharmacology and experimental therapeutics 19960401
Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat. Pharmacology, biochemistry, and behavior 19950501
D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptor participation in experimental catalepsy in rats. Psychopharmacology 19920101
Alpha 2-adrenoceptor-mediated inhibition of prolactin release in suckling- or fenfluramine-induced hyperprolactinemia. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 19910501
Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine. Pharmacology 19910101
Alpha 2-adrenoceptor-blocking properties of midaglizole (DG-5128) in rats. Archives internationales de pharmacodynamie et de therapie 19900101
Comparison of the effects of haloperidol, remoxipride and raclopride on 'pre'- and postsynaptic dopamine receptors in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology 19880401
Pharmacological characterization of spinal alpha adrenoceptors related to blood pressure control in rats. The Journal of pharmacology and experimental therapeutics 19870101
Imidazole has similar behavioural effects to yohimbine. Psychopharmacology 19860101
Behavioural pharmacology of imidazole, a potential antidepressant agent. Archives internationales de pharmacodynamie et de therapie 19851001
Properties