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THIOURIC ACID

CAS No.:
2002-60-0
Catalog Number:
AG00BIHX
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00BIHX
Chemical Name:
THIOURIC ACID
CAS Number:
2002-60-0
MDL Number:
MFCD00871830
IUPAC Name:
6-sulfanylidene-7,9-dihydro-3H-purine-2,8-dione
InChI:
InChI=1S/C5H4N4O2S/c10-4-6-1-2(7-4)8-5(11)9-3(1)12/h(H4,6,7,8,9,10,11,12)
InChI Key:
SXHQUGJSTGOXMD-UHFFFAOYSA-N
UNII:
7F23ZQP3EM
NSC Number:
46380
Properties
Complexity:
334  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
184.005g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
184.173g/mol
Monoisotopic Mass:
184.005g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.3  
Literature
Title Journal
Thiopurine-induced toxicity is associated with dysfunction variant of the human molybdenum cofactor sulfurase gene (xanthinuria type II). Toxicology and applied pharmacology 20180620
Study of drug metabolism by xanthine oxidase. International journal of molecular sciences 20120101
Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines. BMC cancer 20110101
State-of-the-art: Immunosuppression and biologic therapy. Digestive diseases (Basel, Switzerland) 20100101
The development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia--an exploratory study. European journal of clinical pharmacology 20091101
Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease. Alimentary pharmacology & therapeutics 20080915
The role of xanthine oxidase in thiopurine metabolism: a case report. Therapeutic drug monitoring 20071201
In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase. Drug metabolism and pharmacokinetics 20070801
Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Biochemistry. Biokhimiia 20070201
Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol. BMC biochemistry 20070101
Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells. BMC cancer 20060101
HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients. International journal of clinical pharmacology and therapeutics 19951201
Properties