manitimus
| Title | Journal |
|---|---|
| The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro. | Hepatology (Baltimore, Md.) 20120701 |
| A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation. | BMC nephrology 20120101 |
| Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy. | Transplantation 20101027 |
| Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat. | Folia biologica 20100101 |
| Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20091201 |
| The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells. | Transplantation proceedings 20090601 |
| Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. | International journal of molecular medicine 20090301 |
| The new immunosuppressive agent FK778 attenuates neointima formation in an experimental venous bypass graft model. | Vascular pharmacology 20090101 |
| FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model. | Intervirology 20090101 |
| FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101 |
| Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778. | Transplantation 20080327 |
| The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model. | Eye (London, England) 20071201 |
| The effect of FK778 on the progression of chronic allograft nephropathy in a rat model. | Transplantation 20070327 |
| Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection? | Transplantation proceedings 20070301 |
| The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells. | Blood 20070101 |
| Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides? | Cardiology 20070101 |
| Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation. | Journal of leukocyte biology 20070101 |
| FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101 |
| Prolonged survival with FK778 (malononitrilamide) monotherapy after small bowel transplantation: a large animal study. | Transplantation proceedings 20070101 |
| The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. | Transplantation proceedings 20061201 |
| The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | Transplantation proceedings 20061001 |
| Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease. | Transplant international : official journal of the European Society for Organ Transplantation 20060401 |
| FK778: new cellular and molecular mechanisms of action. | Transplantation proceedings 20060401 |
| Role of FK778 alone or in combination with tacrolimus or mTOR inhibitors as an immunomodulator of immunofunctions: in vitro evaluation of T cell proliferation and the expression of lymphocyte surface antigens. | International journal of immunopathology and pharmacology 20060101 |
| FK778 does not impair intestinal allograft absorption in a preclinical model of total small bowel transplantation. | Transplantation proceedings 20060101 |
| FK778 and tacrolimus combination therapy to control acute rejection after pig intestinal transplantation. | Transplantation proceedings 20060101 |
| FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051101 |
| Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778. | Transplantation 20051027 |
| 2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis. | Journal of vascular and interventional radiology : JVIR 20050701 |
| FK-778 Astellas. | Current opinion in investigational drugs (London, England : 2000) 20050501 |
| The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse. | Transplantation proceedings 20050501 |
| Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. | Transplantation 20050115 |
| Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. | Antiviral research 20050101 |
| FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506. | Transplantation proceedings 20050101 |
| In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Efficacy of malononitrilamide FK778 in a preclinical model of small bowel transplantation. | Transplantation proceedings 20050101 |
| Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV. | Transplantation proceedings 20050101 |
| FK778, a synthetic malononitrilamide. | Yonsei medical journal 20041231 |
| FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation. | Transplantation 20041215 |
| FK778: a powerful immunosuppressive, but will it really be good for you? | Transplantation 20040715 |
| The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. | Transplantation 20040715 |
| FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. | Transplantation 20040715 |
| New drugs to improve transplant outcomes. | Transplantation 20040515 |
| The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent. | Transplantation 20040227 |
| New immunosuppressive strategies in renal transplant recipients. | Journal of nephrology 20040101 |
| Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. | Transplantation 20031215 |
| Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. | Transplantation 20030815 |
| Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat. | Transplantation 20030615 |
| Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts. | Transplantation 20030515 |
| In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates. | Transplant international : official journal of the European Society for Organ Transplantation 20030501 |
| FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts. | Transplantation 20030427 |
| Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates. | Transplantation 20030427 |
| Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs. | Transplantation 20030427 |
| Modified noble plication for the prevention of intestinal intussusception after renal transplantation in dogs. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20030101 |
| Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood from non-human primates and healthy human volunteers. | Transplant immunology 20030101 |
| A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs. | Surgery 20020701 |
| An evaluation of combined immunosuppression with MNA 715 and microemulsified cyclosporine on renal allograft rejection in mismatched mongrel dogs. | Veterinary surgery : VS 20020101 |
| Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice. | Transplantation proceedings 20010501 |
| Efficacy of malononitrilamide 715 as immunosuppressant, alone or in combination with cyclosporin, in allogeneic foetal rat pancreatic transplantation. | Transplantation proceedings 20010501 |
| Development of a novel drug for transplantation: current results and future perspectives. | Transplantation proceedings 20010501 |
| Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects? | European journal of biochemistry 20010301 |
| Leflunomide analog, MNA-715, plus cyclosporine reduces renal allograft rejection in mismatched dogs. | Transplantation proceedings 20010101 |
| Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. | Biochemical pharmacology 19981101 |
| Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria. | Biochemical pharmacology 19981015 |