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Imisopasem Manganese

CAS No.:
218791-21-0
Catalog Number:
AG00BGEQ
Molecular Formula:
C21H40Cl2Mn2N5-
Molecular Weight:
543.3579
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
2mg
1 week
United States
$207
- +
5mg
1 week
United States
$307
- +
10mg
1 week
United States
$457
- +
25mg
1 week
United States
$807
- +
50mg
1 week
United States
$1290
- +
100mg
1 week
United States
$1707
- +
Product Description
Catalog Number:
AG00BGEQ
Chemical Name:
Imisopasem Manganese
CAS Number:
218791-21-0
Molecular Formula:
C21H40Cl2Mn2N5-
Molecular Weight:
543.3579
MDL Number:
MFCD09954128
IUPAC Name:
manganese(2+);(4R,9R,14R,19R)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride
InChI:
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1
InChI Key:
WXEMWBBXVXHEPU-XNPJUPKFSA-L
SMILES:
[Cl-][Mn]1234([Cl-])([Mn+])[NH]5CC[NH]1[C@H]1[C@H]([NH]2Cc2n4c(C[NH]3[C@H]3[C@H]5CCCC3)ccc2)CCCC1
UNII:
2Q6R3259KS
Properties
Complexity:
381  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
4  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
482.165g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
483.384g/mol
Monoisotopic Mass:
482.165g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
61A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. Chemico-biological interactions 20170625
Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. Journal of immunotherapy (Hagerstown, Md. : 1997) 20110601
Anesthetic-induced oxidative stress and potential protection. TheScientificWorldJournal 20100101
NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets. American journal of physiology. Lung cellular and molecular physiology 20091001
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells. Thrombosis research 20090901
Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of immunotherapy (Hagerstown, Md. : 1997) 20080501
Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. Free radical biology & medicine 20050815
Reduced development of experimental periodontitis by treatment with M40403, a superoxide dismutase mimetic. European journal of pharmacology 20050601
Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis. Arthritis and rheumatism 20050601
Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-D-aspartate-mediated hyperalgesia. Pain 20040901
M40403 prevents myocardial injury induced by acute hyperglycaemia in perfused rat heart. European journal of pharmacology 20040816
A newly identified role for superoxide in inflammatory pain. The Journal of pharmacology and experimental therapeutics 20040601
Superoxide: a key player in hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040101
Blockade of N-methyl-D-aspartate receptors by phencyclidine causes the loss of corticostriatal neurons. Neuroscience 20040101
Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. British journal of pharmacology 20030701
Effects of the SOD mimetic, M40403, on prostaglandin production in an in vivo model of ischemia and reperfusion in rat heart. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030401
Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. The Journal of pharmacology and experimental therapeutics 20030101
An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Molecular medicine (Cambridge, Mass.) 20020901
A role for superoxide in gentamicin-mediated nephropathy in rats. European journal of pharmacology 20020816
Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. British journal of pharmacology 20020701
Superoxide, superoxide dismutase and ischemic injury. Current opinion in investigational drugs (London, England : 2000) 20020601
Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion. Journal of andrology 20020101
Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic. Arthritis and rheumatism 20011201
Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis. European journal of pharmacology 20011130
Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. British journal of pharmacology 20010901
Computer-aided design (CAD) of Mn(II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme. Inorganic chemistry 20010409
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. British journal of pharmacology 20010201
Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. British journal of pharmacology 20010101
Properties