The combination of OLmesartan and a CAlcium channel blocker (azelnidipine) or candesartan and a calcium channel blocker (amlodipine) in type 2 diabetic hypertensive patients: the OLCA study.

Diabetes & vascular disease research 20121001

Getting a sense for signals: regulation of the plant iron deficiency response.

Biochimica et biophysica acta 20120901

The zinc homeostasis network of land plants.

Biochimica et biophysica acta 20120901

Production of N-acetyl cis-4-hydroxy-L-proline by the yeast N-acetyltransferase Mpr1.

Journal of bioscience and bioengineering 20120801

Association of changes in ambulatory arterial stiffness index and pulse wave velocity during antihypertensive treatment: the J-CORE study.

American journal of hypertension 20120801

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

Molecular cell 20120713

A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.

The Journal of biological chemistry 20120706

Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like α·β blocker.

Journal of cardiology 20120701

Senescence-induced iron mobilization in source leaves of barley (Hordeum vulgare) plants.

The New phytologist 20120701

Combined effect of angiotensin II receptor blocker and either a calcium channel blocker or diuretic on day-by-day variability of home blood pressure: the Japan Combined Treatment With Olmesartan and a Calcium-Channel Blocker Versus Olmesartan and Diuretics Randomized Efficacy Study.

Hypertension (Dallas, Tex. : 1979) 20120601

Calcium antagonist added to angiotensin receptor blocker: a recipe for reducing blood pressure variability?: evidence from day-by-day home blood pressure monitoring.

Hypertension (Dallas, Tex. : 1979) 20120601

Nicotianamine functions in the Phloem-based transport of iron to sink organs, in pollen development and pollen tube growth in Arabidopsis.

The Plant cell 20120601

Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis.

Plant physiology 20120401

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.

The Journal of biological chemistry 20120309

Mechanistic study on degradation of azelnidipine solution under radical initiator-based oxidative conditions.

Journal of pharmaceutical and biomedical analysis 20120305

Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity.

Hypertension research : official journal of the Japanese Society of Hypertension 20120301

Enhancement of anthraquinone production in Morinda citrifolia cell suspension cultures after stimulation of the proline cycle with two proline analogs.

Biotechnology letters 20120301

Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.

British journal of pharmacology 20120201

Identification of Zn-nicotianamine and Fe-2'-Deoxymugineic acid in the phloem sap from rice plants (Oryza sativa L.).

Plant & cell physiology 20120201

Nicotianamine in zinc and iron homeostasis.

The Plant cell 20120201

Elevated nicotianamine levels in Arabidopsis halleri roots play a key role in zinc hyperaccumulation.

The Plant cell 20120201

Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis.

The Plant cell 20120201

Analysis of iron-phytosiderophore complexes in soil related samples: LC-ESI-MS/MS versus CE-MS.

Electrophoresis 20120201

Effects of ring contraction on the conformational preferences of α-substituted proline analogs.

Biopolymers 20120101

Olmesartan medoxomil and azelnidipine therapy in patients with hypertension and chronic kidney disease in Japan.

Journal of nephrology 20120101

Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101

Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney disease: a randomized controlled study.

American journal of nephrology 20120101

Solid state characterizations and analysis of stability in azelnidipine polymorphs.

Chemical & pharmaceutical bulletin 20120101

Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells.

International heart journal 20120101

Genetic and biochemical approaches for studying the yellow stripe-like transporter family in plants.

Current topics in membranes 20120101

Bio-available zinc in rice seeds is increased by activation tagging of nicotianamine synthase.

Plant biotechnology journal 20111001

Synthesis, antiproliferative activity and DNA binding study of mixed ammine/cyclohexylamine platinum(II) complexes with 1-(substituted benzyl) azetidine-3, 3-dicarboxylates.

European journal of medicinal chemistry 20111001

Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity.

FEBS letters 20110902

Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation.

Journal of neuroscience research 20110901

The binding of aluminum to mugineic acid and related compounds as studied by potentiometric titration.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110801

Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria.

Cardiovascular drugs and therapy 20110801

Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria.

Hypertension research : official journal of the Japanese Society of Hypertension 20110801

L-/T-type Ca channel blockers for kidney protection: ready for sophisticated use of Ca channel blockers.

Hypertension research : official journal of the Japanese Society of Hypertension 20110801

Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.

PLoS genetics 20110801

Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats.

The Journal of surgical research 20110701

A novel transcription factor, ERD15 (Early Responsive to Dehydration 15), connects endoplasmic reticulum stress with an osmotic stress-induced cell death signal.

The Journal of biological chemistry 20110603

Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease.

Clinical cardiology 20110601

The role of transition metal homeostasis in plant seed development.

Current opinion in plant biology 20110601

Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis.

The Plant cell 20110501

Urinary albumin excretion during angiotensin II receptor blockade: comparison of combination treatment with a diuretic or a calcium-channel blocker.

American journal of hypertension 20110401

Reduction of albuminuria with antihypertensive treatment: is more always better?

American journal of hypertension 20110401

Association between aldosterone induced by antihypertensive medication and arterial stiffness reduction: the J-CORE study.

Atherosclerosis 20110301

Phytosiderophore efflux transporters are crucial for iron acquisition in graminaceous plants.

The Journal of biological chemistry 20110218

Co-treatment with azelinidipine and olmesartan inhibits advanced glycation end products (AGEs) elicited down-regulation of adiponectin mRNA levels in cultured adipocytes partly via its anti-oxidative property.

International journal of cardiology 20110121

N-aminoazetidinecarboxylic acid: direct access to a small-ring hydrazino acid.

The Journal of organic chemistry 20110121

Use of recombinantly produced 15N3-labelled nicotianamine for fast and sensitive stable isotope dilution ultra-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry.

Analytical and bioanalytical chemistry 20110101

Transcriptome profiling of the rice blast fungus during invasive plant infection and in vitro stresses.

BMC genomics 20110101

Comparison of combination therapy of olmesartan plus azelnidipine or hydrochlorothiazide on renal and vascular damage in SHR/NDmcr-cp rats.

Kidney & blood pressure research 20110101

Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo University (ALPS-J).

Circulation journal : official journal of the Japanese Circulation Society 20110101

Comparative effects of azelnidipine and amlodipine on myocardial function and mortality after ischemia/reperfusion in dogs.

Journal of pharmacological sciences 20110101

Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1.

BMC biology 20110101

Intravascular ultrasound parameters in non-inferiority trial.

Circulation journal : official journal of the Japanese Circulation Society 20110101

The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.

PloS one 20110101

Effects of Azelnidipine plus OlmesaRTAn versus amlodipine plus olmesartan on central blood pressure and left ventricular mass index: the AORTA study.

Vascular health and risk management 20110101

Functional compounds in fermented buckwheat sprouts.

Bioscience, biotechnology, and biochemistry 20110101

Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).

Cardiovascular diabetology 20110101

Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis.

Cardiovascular diabetology 20110101

Mugineic acid derivatives as molecular probes for the mechanistic elucidation of iron acquisition in barley.

Angewandte Chemie (International ed. in English) 20101217

Azelnidipine-induced chyloperitoneum in a patient with microscopic polyangiitis.

Clinical and experimental nephrology 20101001

A 9 bp cis-element in the promoters of class I small heat shock protein genes on chromosome 3 in rice mediates L-azetidine-2-carboxylic acid and heat shock responses.

Journal of experimental botany 20101001

Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures.

Plant physiology 20100901

Plant Physiology. On the inside.

Plant physiology 20100901

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

Bioorganic & medicinal chemistry letters 20100801

The application of the yeast N-acetyltransferase MPR1 gene and the proline analogue L-azetidine-2-carboxylic acid as a selectable marker system for plant transformation.

Journal of experimental botany 20100601

Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients.

The American journal of the medical sciences 20100501

[Heavy metal absorption, transportation and accumulation mechanisms in hyperaccumulator Thlaspi caerulescens].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20100501

Effects of combination olmesartan medoxomil plus azelnidipine versus monotherapy with either agent on 24-hour ambulatory blood pressure and pulse rate in Japanese patients with essential hypertension: additional results from the REZALT study.

Clinical therapeutics 20100501

Misincorporation of the proline homologue Aze (azetidine-2-carboxylic acid) into recombinant myelin basic protein.

Phytochemistry 20100401

Response to zinc deficiency of two rice lines with contrasting tolerance is determined by root growth maintenance and organic acid exudation rates, and not by zinc-transporter activity.

The New phytologist 20100401

Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice.

Circulation journal : official journal of the Japanese Circulation Society 20100401

Complexation of metals by phytosiderophores revealed by CE-ESI-MS and CE-ICP-MS.

Electrophoresis 20100401

Toward mechanistic elucidation of iron acquisition in barley: efficient synthesis of mugineic acids and their transport activities.

Chemical record (New York, N.Y.) 20100401

Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog.

Basic & clinical pharmacology & toxicology 20100201

Heterologous expression of Saccharomyces cerevisiae MPR1 gene confers tolerance to ethanol and L: -azetidine-2-carboxylic acid in Hansenula polymorpha.

Journal of industrial microbiology & biotechnology 20100201

[Enantiomeric separation of azelnidipine by high performance liquid chromatography with chiral stationary phase].

Se pu = Chinese journal of chromatography 20100201

Azelnidipine, a long-acting calcium channel blocker, could control hypertension without decreasing cerebral blood flow in post-ischemic stroke patients. A 123I-IMP SPECT follow-up study.

Hypertension research : official journal of the Japanese Society of Hypertension 20100101

[Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system].

Clinical calcium 20100101

Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients.

Internal medicine (Tokyo, Japan) 20100101

Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

Nicotianamine, a novel enhancer of rice iron bioavailability to humans.

PloS one 20100101

Cytokine reducing effect of azelnidipine in human peripheral blood mononuclear cells.

Biological & pharmaceutical bulletin 20100101

Studies on the mechanism of antihypertensive action by nicotianamine.

Journal of nutritional science and vitaminology 20100101

Azelnidipine and amlodipine: a comparison of their effects and safety in a randomized double-blinded clinical trial in Chinese essential hypertensive patients.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

Nicotianamine forms complexes with Zn(II) in vivo.

Metallomics : integrated biometal science 20100101

Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage.

Cardiovascular diabetology 20100101

Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091201

A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study.

Hypertension research : official journal of the Japanese Society of Hypertension 20091201

Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension 20091101

MPR1 as a novel selection marker in Saccharomyces cerevisiae.

Yeast (Chichester, England) 20091101

A highly sensitive, quick and simple quantification method for nicotianamine and 2'-deoxymugineic acid from minimum samples using LC/ESI-TOF-MS achieves functional analysis of these components in plants.

Plant & cell physiology 20091101

Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients.

Hypertension (Dallas, Tex. : 1979) 20091001

Central blood pressure under angiotensin and calcium channel blockade.

Hypertension (Dallas, Tex. : 1979) 20091001

Impact of azelnidipine treatment on left ventricular diastolic performance in patients with hypertension and mild diastolic dysfunction: multi-center study with echocardiography.

Hypertension research : official journal of the Japanese Society of Hypertension 20091001

Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation.

American journal of hypertension 20091001

Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo university (ALPS-J).

Cardiovascular drugs and therapy 20091001

Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats.

Journal of hypertension 20090901

Highly efficient and enantioselective biotransformations of racemic azetidine-2-carbonitriles and their synthetic applications.

The Journal of organic chemistry 20090821

OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints.

Plant molecular biology 20090801

Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

Bioorganic & medicinal chemistry letters 20090801

Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers.

Journal of cardiovascular pharmacology 20090701

Engineering of the yeast antioxidant enzyme Mpr1 for enhanced activity and stability.

Biotechnology and bioengineering 20090601

Combination use of immune complexes and a Ca2(+) channel blocker azelnidipine enhances interleukin-12 p40 secretion without T helper type 17 cytokine secretion in human monocyte-derived dendritic cells.

Clinical and experimental immunology 20090601

The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses.

Plant physiology 20090501

The heat-induced gamma-H2AX response does not play a role in hyperthermic cell killing.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090501

Therapeutic strategy for ischemic stroke.

Neurochemical research 20090401

Chronotropic effects of azelnidipine, a slow- and long-acting dihydropyridine-type calcium channel blocker, in anesthetized dogs: a comparison with amlodipine.

Journal of cardiovascular pharmacology 20090401

Time course analysis of gene expression over 24 hours in Fe-deficient barley roots.

Plant molecular biology 20090301

Azelnidipine inhibits aldosterone synthesis and secretion in human adrenocortical cell line NCI-H295R.

European journal of pharmacology 20090301

Increased sensitivity to iron deficiency in Arabidopsis thaliana overaccumulating nicotianamine.

Journal of experimental botany 20090301

Rice OsYSL15 is an iron-regulated iron(III)-deoxymugineic acid transporter expressed in the roots and is essential for iron uptake in early growth of the seedlings.

The Journal of biological chemistry 20090206

Engineering of the yeast ubiquitin ligase Rsp5: isolation of a new variant that induces constitutive inactivation of the general amino acid permease Gap1.

FEMS yeast research 20090201

Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists.

American journal of hypertension 20090201

The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis.

The Plant cell 20090201

Time-course study and effects of drying method on concentrations of gamma-aminobutyric acid, flavonoids, anthocyanin, and 2''-hydroxynicotianamine in leaves of buckwheats.

Journal of agricultural and food chemistry 20090114

Genetically engineered rice containing larger amounts of nicotianamine to enhance the antihypertensive effect.

Plant biotechnology journal 20090101

Metal movement within the plant: contribution of nicotianamine and yellow stripe 1-like transporters.

Annals of botany 20090101

Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors.

ChemMedChem 20090101

Nicotianamine and histidine/proline are, respectively, the most important copper chelators in xylem sap of Brassica carinata under conditions of copper deficiency and excess.

Journal of experimental botany 20090101

Azetidine-2-carboxylic acid in the food chain.

Phytochemistry 20090101

Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi.

PloS one 20090101

Synthesis and biological activity of nicotianamine and analogues.

Advances in experimental medicine and biology 20090101

Comparative effects of olmesartan and azelnidipine on atrial structural remodeling in spontaneously hypertensive rats.

Pharmacology 20090101

Gene and stem cell therapy in ischemic stroke.

Cell transplantation 20090101

Comparative pharmacodynamics of olmesartan and azelnidipine in patients with hypertension: a population pharmacokinetic/pharmacodynamic analysis.

Drug metabolism and pharmacokinetics 20090101

Beneficial effects of combination therapy with olmesartan and azelnidipine in murine polycystic kidneys.

Kidney & blood pressure research 20090101

The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20090101

Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair.

The Kurume medical journal 20090101

Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension.

Cardiovascular research 20081201

Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation.

Biomaterials 20081201

Renoprotective effect of azelnidipine in rats.

Biological & pharmaceutical bulletin 20081201

Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.

Journal of cardiovascular pharmacology 20081201

Hemodynamic influences of azelnidipine, a novel calcium channel blocker, on cerebral circulation in hypertensive patients with ischemic white matter lesions.

Hypertension research : official journal of the Japanese Society of Hypertension 20081201

Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis.

Journal of neuropathology and experimental neurology 20081101

A novel unifying hypothesis of multiple sclerosis.

Journal of neuropathology and experimental neurology 20081101

Additional renoprotective effects of azelnidipine combined with angiotensin receptor blockers in patients with diabetic nephropathy.

Clinical nephrology 20081101

Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20081001

Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers.

Die Pharmazie 20080801

In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diabetes (ATTEST) study.

Hypertension research : official journal of the Japanese Society of Hypertension 20080801

In vivo imaging of renal redox status during azelnidipine treatment.

Hypertension research : official journal of the Japanese Society of Hypertension 20080801

Identification of amino acid residues essential for the yeast N-acetyltransferase Mpr1 activity by site-directed mutagenesis.

FEMS yeast research 20080601

Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy.

Hypertension research : official journal of the Japanese Society of Hypertension 20080601

Formation of metal-nicotianamine complexes as affected by pH, ligand exchange with citrate and metal exchange. A study by electrospray ionization time-of-flight mass spectrometry.

Rapid communications in mass spectrometry : RCM 20080501

Deoxymugineic acid increases Zn translocation in Zn-deficient rice plants.

Plant molecular biology 20080401

Effects of azelnidipine on the autonomic functions and its influence on arterial stiffness and endothelial functions.

Journal of cardiology 20080401

Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction.

The Journal of organic chemistry 20080307

Spectroscopic studies on the interaction of azelnidipine with bovine serum albumin.

International journal of pharmaceutics 20080303

Effects of antihypertensive drugs and exercise training on insulin sensitivity in spontaneously hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20080301

Distribution of L-azetidine-2-carboxylate N-acetyltransferase in yeast.

Bioscience, biotechnology, and biochemistry 20080201

Azelnidipine has anti-atherosclerotic effects independent of its blood pressure-lowering actions in monkeys and mice.

Atherosclerosis 20080101

Isotopomer-based metabolomic analysis by NMR and mass spectrometry.

Methods in cell biology 20080101

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery.

BMC cell biology 20080101

Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure.

Endocrine journal 20071201

Mutation in nicotianamine aminotransferase stimulated the Fe(II) acquisition system and led to iron accumulation in rice.

Plant physiology 20071201

Prevention of neuronal damage by calcium channel blockers with antioxidative effects after transient focal ischemia in rats.

Brain research 20071024

CE of phytosiderophores and related metal species in plants.

Electrophoresis 20071001

Hsp70-GlcNAc-binding activity is released by stress, proteasome inhibition, and protein misfolding.

Biochemical and biophysical research communications 20070921

The rice bHLH protein OsIRO2 is an essential regulator of the genes involved in Fe uptake under Fe-deficient conditions.

The Plant journal : for cell and molecular biology 20070801

Nicotianamine preferentially inhibits Angiotensin I-converting enzyme.

Journal of nutritional science and vitaminology 20070801

Antioxidative effects of azelnidipine on mesangial cell proliferation induced by highly concentrated insulin.

European journal of pharmacology 20070719

Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Iron utilization and metabolism in plants.

Current opinion in plant biology 20070601

Azelnidipine reduces urinary protein excretion and urinary liver-type fatty acid binding protein in patients with hypertensive chronic kidney disease.

The American journal of the medical sciences 20070601

Effects of new calcium channel blocker, azelnidipine, and amlodipine on baroreflex sensitivity and ambulatory blood pressure.

Journal of cardiovascular pharmacology 20070601

Effect of benidipine on simvastatin metabolism in human liver microsomes.

Drug metabolism and pharmacokinetics 20070601

The expression of iron homeostasis-related genes during rice germination.

Plant molecular biology 20070501

[Responses to iron-deficiency stress by graminaceous plants].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20070501

The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction.

Journal of pharmacological sciences 20070401

Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20070401

Highly sensitive quantitative analysis of nicotianamine using LC/ESI-TOF-MS with an internal standard.

Bioscience, biotechnology, and biochemistry 20070201

Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes.

Cardiovascular drugs and therapy 20070201

Determination of azelnidipine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20070117

TcYSL3, a member of the YSL gene family from the hyper-accumulator Thlaspi caerulescens, encodes a nicotianamine-Ni/Fe transporter.

The Plant journal : for cell and molecular biology 20070101

Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20070101

Effects of calcium channel blocker azelnidipine on experimental abdominal aortic aneurysms.

Surgery today 20070101

A practical synthesis of the phytosiderophore 2'-deoxymugineic acid: a key to the mechanistic study of iron acquisition by graminaceous plants.

Angewandte Chemie (International ed. in English) 20070101

Relationships of nicotianamine and other amino acids with nickel, zinc and iron in Thlaspi hyperaccumulators.

The New phytologist 20070101

Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity.

Arzneimittel-Forschung 20070101

SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition.

European journal of pharmacology 20061215

Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan.

The Journal of pharmacology and experimental therapeutics 20061201

Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients: effects of azelnidipine.

Hypertension research : official journal of the Japanese Society of Hypertension 20061201

Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

The actions of azelnidipine, a dihydropyridine-derivative Ca antagonist, on voltage-dependent Ba2+ currents in guinea-pig vascular smooth muscle.

British journal of pharmacology 20061101

Cloning and characterization of deoxymugineic acid synthase genes from graminaceous plants.

The Journal of biological chemistry 20061027

Anion exchange liquid chromatography--inductively coupled plasma-mass spectrometry detection of the Co2+, Cu2+, Fe3+ and Ni2+ complexes of mugineic and deoxymugineic acid.

Journal of chromatography. A 20061006

The calcium-channel blocker, azelnidipine, enhances the inhibitory action of AT1 receptor blockade on ischemic brain damage.

Journal of hypertension 20061001

Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.

Journal of hypertension 20061001

Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley.

The Plant journal : for cell and molecular biology 20061001

Azelnidipine down-regulates renal angiotensin-converting enzyme and mineralocorticoid receptor mRNA in diabetic hypertensive rats.

Journal of pharmacological sciences 20061001

Efficacy of azelnidipine on home blood pressure and pulse rate in patients with essential hypertension: comparison with amlodipine.

Hypertension research : official journal of the Japanese Society of Hypertension 20061001

Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.

European journal of pharmacology 20060928

A third-generation, long-acting, dihydropyridine calcium antagonist, azelnidipine, attenuates stent-associated neointimal formation in non-human primates.

Journal of hypertension 20060901

S-Adenosyl-L-methionine: beyond the universal methyl group donor.

Phytochemistry 20060801

[Novel actions of calcium channel blockers].

Nihon rinsho. Japanese journal of clinical medicine 20060801

[Study on the structure activity relationship of a phytosiderophore, mugineic acid].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060701

Metabolic engineering of Saccharomyces cerevisiae producing nicotianamine: potential for industrial biosynthesis of a novel antihypertensive substrate.

Bioscience, biotechnology, and biochemistry 20060601

Genetically modified cyanobacterium Nostoc muscorum overproducing proline in response to salinity and osmotic stresses.

Journal of biosciences 20060601

The transition metal chelator nicotianamine is synthesized by filamentous fungi.

FEBS letters 20060529

Azetidine-2-carboxylic acid in garden beets (Beta vulgaris).

Phytochemistry 20060501

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

The Biochemical journal 20060401

The special five-membered ring of proline: An experimental and theoretical investigation of alkali metal cation interactions with proline and its four- and six-membered ring analogues.

The journal of physical chemistry. A 20060323

Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats.

The Journal of pharmacology and experimental therapeutics 20060301

An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour.

Phytochemistry 20060301

Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells.

Journal of cardiovascular pharmacology 20060201

Distinct yet linked: chaperone networks in the eukaryotic cytosol.

Genome biology 20060101

Investigation of 1,3-dipolar cycloaddition reactions of unsaturated nitrones in ionic liquids.

Nucleosides, nucleotides & nucleic acids 20060101

The newly developed calcium antagonist, azelnidipine, increases drain volume in continuous ambulatory peritoneal dialysis patients.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101

Expression of the Saccharomyces cerevisiae MPR1 gene encoding N-acetyltransferase in Zygosaccharomyces rouxii confers resistance to L-azetidine-2-carboxylate.

Folia microbiologica 20060101

Root-to-shoot long-distance circulation of nicotianamine and nicotianamine-nickel chelates in the metal hyperaccumulator Thlaspi caerulescens.

Journal of experimental botany 20060101

Azelnidipine, a new long-acting calcium-channel blocker, inhibits tumour necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells.

The Journal of international medical research 20060101

Protein synthesis upon acute nutrient restriction relies on proteasome function.

Science (New York, N.Y.) 20051223

A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading.

The Plant journal : for cell and molecular biology 20051201

Effects of a new calcium channel blocker, azelnidipine, on systemic hemodynamics and renal sympathetic nerve activity in spontaneously hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20051201

Increased nicotianamine biosynthesis confers enhanced tolerance of high levels of metals, in particular nickel, to plants.

Plant & cell physiology 20051101

Practical asymmetric preparation of azetidine-2-carboxylic acid.

The Journal of organic chemistry 20051028

Efficient route to (S)-azetidine-2-carboxylic acid.

Bioscience, biotechnology, and biochemistry 20051001

Nicotianamine over-accumulation confers resistance to nickel in Arabidopsis thaliana.

Transgenic research 20051001

Functional effects of Japanese style fermented soy sauce (shoyu) and its components.

Journal of bioscience and bioengineering 20050901

Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice.

Journal of hypertension 20050701

Effect of azelnidipine on angiotensin II-mediated growth-promoting signaling in vascular smooth muscle cells.

Molecular pharmacology 20050501

Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response.

Molecular and biochemical parasitology 20050501

Mg-dechelation activity in radish cotyledons with artificial and native substrates, Mg-chlorophyllin a and chlorophyllide a.

Plant physiology and biochemistry : PPB 20050501

Stereoselective allyl amine synthesis through enantioselective addition of diethylzinc and [1,3]-chirality transfer: synthesis of lentiginosine and polyoxamic acid derivative.

Chemistry (Weinheim an der Bergstrasse, Germany) 20050304

Amino acid-azetidine chimeras: synthesis of enantiopure 3-substituted azetidine-2-carboxylic acids.

The journal of peptide research : official journal of the American Peptide Society 20050201

Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).

British journal of pharmacology 20050101

Unique atheroprotective property of azelnidipine, a dihydropyridine-based calcium antagonist.

Medical hypotheses 20050101

Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture.

Neuroscience 20050101

Renoprotective effects of azelnidipine, a dihydropyridine-based calcium antagonist in advanced glycation end product (AGE)-injected rats.

International journal of tissue reactions 20050101

Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and downregulation of pigment epithelium-derived factor mRNA levels in microvascular endothelial cells.

Drugs under experimental and clinical research 20050101

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

The Journal of biological chemistry 20041231

Azetidine-induced accumulation of class I small heat shock proteins in the soluble fraction provides thermotolerance in soybean seedlings.

Plant & cell physiology 20041201

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress.

The Journal of biological chemistry 20041126

Characterization of the genomic structures and selective expression profiles of nine class I small heat shock protein genes clustered on two chromosomes in rice (Oryza sativa L.).

Plant molecular biology 20041101

Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.

Hypertension research : official journal of the Japanese Society of Hypertension 20041001

Arabidopsis Yellow Stripe-Like2 (YSL2): a metal-regulated gene encoding a plasma membrane transporter of nicotianamine-metal complexes.

The Plant journal : for cell and molecular biology 20040801

OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem.

The Plant journal : for cell and molecular biology 20040801

Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties.

Journal of cardiovascular pharmacology 20040501

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.

Biochemical and biophysical research communications 20040430

Biliary excretion of azelnidipine, a calcium antagonist, in rats.

Journal of gastroenterology and hepatology 20040401

ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.

The Journal of biological chemistry 20040305

Expression of a novel yeast gene that detoxifies the proline analog azetidine-2-carboxylate confers resistance during tobacco seed germination, callus and shoot formation.

Plant cell reports 20040301

Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.

Hypertension (Dallas, Tex. : 1979) 20040201

Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast.

Yeast (Chichester, England) 20040201

Antioxidant effect of a new calcium antagonist, azelnidipine, in cultured human arterial endothelial cells.

The Journal of international medical research 20040101

Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells.

Cell biology international 20040101

[Pharmacological profiles and clinical effects of azelnidipine, a long-acting calcium channel blocker].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20031201

Enantiospecific total synthesis of (-)-polyoxamic acid using 2,3-aziridino-gamma-lactone methodology.

The Journal of organic chemistry 20031128

Metabotropic receptor-mediated Ca2+ signaling elevates mitochondrial Ca2+ and stimulates oxidative metabolism in hippocampal slice cultures.

Journal of neurophysiology 20030801

Discovery of an extended bundle sheath in Ricinus communis L. and its role as a temporal storage compartment for the iron chelator nicotianamine.

Planta 20030701

Role of nicotianamine in the intracellular delivery of metals and plant reproductive development.

The Plant cell 20030601

Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure.

Hypertension research : official journal of the Japanese Society of Hypertension 20030301

Structure-activity relationships of dynorphin analogs substituted in positions 2 and 3.

Biopolymers 20030101

Azelnidipine. CS 905, Calblock, RS 9054.

Drugs in R&D 20030101

Characterization of novel acetyltransferases found in budding and fission yeasts that detoxify a proline analogue, azetidine-2-carboxylic acid.

Journal of biochemistry 20030101

Azelnidipine.

Drugs 20030101

Activation of glutamate transporters in rods inhibits presynaptic calcium currents.

Visual neuroscience 20030101

Novel function of ascorbic acid as an angiostatic factor.

Angiogenesis 20030101

Reduced Cd accumulation in Zea mays: a protective role for phytosiderophores?

Environmental science & technology 20021215

Polymorphism of the MPR1 gene required for toxic proline analogue resistance in the Saccharomyces cerevisiae complex species.

Yeast (Chichester, England) 20021201

Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae.

The Journal of biological chemistry 20021122

Asymmetric synthesis of polyhydroxy alpha-amino acids with the sulfinimine-mediated asymmetric strecker reaction: 2-amino 2-deoxy L-xylono-1,5-lactone (polyoxamic acid lactone).

The Journal of organic chemistry 20021101

Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination.

The Journal of biological chemistry 20020913

FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.

The Plant cell 20020801

Revisiting the metal-binding chemistry of nicotianamine and 2'-deoxymugineic acid. Implications for iron nutrition in strategy II plants.

Plant physiology 20020801

Differential expression of two stress-inducible hsp70 genes by various stressors.

Experimental & molecular medicine 20020531

Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a calcium antagonist: beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal ablation.

Hypertension research : official journal of the Japanese Society of Hypertension 20020501

cDNA microarray analysis of gene expression during Fe-deficiency stress in barley suggests that polar transport of vesicles is implicated in phytosiderophore secretion in Fe-deficient barley roots.

The Plant journal : for cell and molecular biology 20020401

A novel acetyltransferase found in Saccharomyces cerevisiae Sigma1278b that detoxifies a proline analogue, azetidine-2-carboxylic acid.

The Journal of biological chemistry 20011109

Fe homeostasis in plant cells: does nicotianamine play multiple roles in the regulation of cytoplasmic Fe concentration?

Planta 20011001

Determination of phytosiderophores by anion-exchange chromatography with pulsed amperometric detection.

Journal of chromatography. A 20010914

Real-time [11C]methionine translocation in barley in relation to mugineic acid phytosiderophore biosynthesis.

Planta 20010901

Improving rice yields--ironing out the details.

Nature biotechnology 20010501

In vivo evidence that Ids3 from Hordeum vulgare encodes a dioxygenase that converts 2'-deoxymugineic acid to mugineic acid in transgenic rice.

Planta 20010401

Coinduction of two low-molecular-weight stress proteins, alpha B crystallin and HSP28, by heat or arsenite stress in human glioma cells.

Journal of biochemistry 19931101

Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker.

Japanese journal of pharmacology 19890901