Home Other Building Blocks Zotarolimus

Zotarolimus

CAS No.:
221877-54-9
Catalog Number:
AG00BF84
Molecular Formula:
C52H79N5O12
Molecular Weight:
966.2100
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥ 98% (Assay: anhydrous basis)
1 week
United States
$140
- +
5mg
≥ 98% (Assay: anhydrous basis)
1 week
United States
$265
- +
10mg
98%
1 week
United States
$457
- +
25mg
≥ 98% (Assay: anhydrous basis)
1 week
United States
$696
- +
Product Description
Catalog Number:
AG00BF84
Chemical Name:
Zotarolimus
CAS Number:
221877-54-9
Molecular Formula:
C52H79N5O12
Molecular Weight:
966.2100
MDL Number:
MFCD09752954
IUPAC Name:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-12-[(2R)-1-[(1S,3R,4S)-3-methoxy-4-(tetrazol-1-yl)cyclohexyl]propan-2-yl]-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
InChI:
InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
InChI Key:
CGTADGCBEXYWNE-JUKNQOCSSA-N
SMILES:
CO[C@@H]1C[C@@H](CC[C@@H]1n1cnnn1)C[C@H]([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H](CC[C@H]2C)C[C@H](OC)/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C1)C)/C)O)OC)C)C)/C)C
UNII:
H4GXR80IZE
Properties
Complexity:
1890  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
15  
Defined Bond Stereocenter Count:
4  
Exact Mass:
965.573g/mol
Formal Charge:
0
Heavy Atom Count:
69  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
966.227g/mol
Monoisotopic Mass:
965.573g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
219A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.9  
Literature
Title Journal
Endothelial progenitor cell response to antiproliferative drug exposure. Atherosclerosis 20121101
Stent thrombosis and major clinical events at 3 years after zotarolimus-eluting or sirolimus-eluting coronary stent implantation: a randomised, multicentre, open-label, controlled trial. Lancet (London, England) 20121020
A new strategy for discontinuation of dual antiplatelet therapy: the RESET Trial (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation). Journal of the American College of Cardiology 20121009
Comparison of twelve-month outcomes after percutanous coronary intervention with everolimus-eluting versus zotarolimus-eluting or sirolimus-eluting stents from the PROENCY (PROmus ENdeavor CYpher) registry. The Journal of invasive cardiology 20121001
Vascular healing in drug-eluting stents: differential drug-associated response of limus-eluting stents in a preclinical model of stent implantation. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20121001
Unprotected left main coronary artery stenting with zotarolimus (Endeavor) drug-eluting stents: a single center retrospective experience. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120801
Optical coherence tomographic comparison of neointimal coverage between sirolimus- and resolute zotarolimus-eluting stents at 9 months after stent implantation. The international journal of cardiovascular imaging 20120801
Frequency and impact of bleeding in elective coronary stent clinical trials--utility of three commonly used definitions. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120801
Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression. Journal of cardiovascular pharmacology 20120801
Short- and long-term outcomes with drug-eluting and bare-metal coronary stents: a mixed-treatment comparison analysis of 117 762 patient-years of follow-up from randomized trials. Circulation 20120612
Inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter. Clinical research in cardiology : official journal of the German Cardiac Society 20120601
Gender differences in patients treated with the zotarolimus-eluting stent at a tertiary medical center. The Journal of invasive cardiology 20120601
Limus is not limus--a proposal to adjust terminology in the context of drug-eluting stents. Journal of cardiovascular pharmacology 20120501
Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial. Circulation 20120424
A randomized controlled trial in second-generation zotarolimus-eluting Resolute stents versus everolimus-eluting Xience V stents in real-world patients: the TWENTE trial. Journal of the American College of Cardiology 20120410
Major determinants for the uncovered stent struts on optical coherence tomography after drug-eluting stent implantation. The international journal of cardiovascular imaging 20120401
Optical coherence tomography findings of very late stent thrombosis after drug-eluting stent implantation. The international journal of cardiovascular imaging 20120401
DUrable polymer-based sTent CHallenge of Promus ElemEnt versus ReSolute integrity (DUTCH PEERS): rationale and study design of a randomized multicenter trial in a Dutch all-comers population. American heart journal 20120401
ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT). American heart journal 20120401
Resolute Italian study in all comers: immediate and one-year outcomes. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120301
One-year outcomes of patients with the zotarolimus-eluting coronary stent: RESOLUTE International Registry. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120201
A case of subacute thrombosis associated with clopidogrel resistance after implantation of a zotarolimus-eluting stent. Heart and vessels 20120101
Randomized comparison of the efficacy and safety of zotarolimus-eluting stents vs. sirolimus-eluting stents for percutaneous coronary intervention in chronic total occlusion--CAtholic Total Occlusion Study (CATOS) trial. Circulation journal : official journal of the Japanese Circulation Society 20120101
Clinical outcomes after treatment of multiple lesions with zotarolimus-eluting versus sirolimus-eluting coronary stents (a SORT OUT III substudy). BMC cardiovascular disorders 20120101
The 'Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & antiplatelet REgimen' (HOST-ASSURE) trial: study protocol for a randomized controlled trial. Trials 20120101
Outcomes of patients treated with the everolimus-eluting stent versus the zotarolimus eluting stent in a consecutive cohort of patients at a tertiary medical center. Vascular health and risk management 20120101
Comparison of pharmacokinetics of the limus-eluting stents in Japanese patients. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201
Comparison of zotarolimus- versus everolimus-eluting stents in the treatment of coronary bifurcation lesions. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201
Three-year clinical outcome with the Endeavor™ zotarolimus-eluting stent in primary percutaneous coronary intervention for ST elevation myocardial infarction: the Endeavor™ primary PCI study (E-PPCI). Journal of interventional cardiology 20111201
Comparison of zotarolimus-eluting stents versus sirolimus-eluting stents versus paclitaxel-eluting stents for primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: results from the Korean Multicentre Endeavor (KOMER) acute myocardial infarction (AMI) trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20111201
Bifurcation stenting with a provisional T strategy: drug eluting stent type does matter. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20111201
Risk of target lesion failure in relationship to vessel angiographic geometry and stent conformability using the second generation of drug-eluting stents. American heart journal 20111201
Differences in drug-eluting stents used in coronary artery disease. The American journal of the medical sciences 20111101
Outcome of sirolimus-eluting versus zotarolimus-eluting coronary stent implantation in patients with and without diabetes mellitus (a SORT OUT III Substudy). The American journal of cardiology 20111101
Clinical outcome of B2/C type isolated proximal LAD disease treated with drug-eluting stents. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111101
Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial. European heart journal 20111001
Sex differences in neointimal hyperplasia following endeavor zotarolimus-eluting stent implantation. The American journal of cardiology 20111001
Evaluation of zotarolimus-eluting metal stent in animal ureters. Journal of endourology 20111001
Vascular response to zotarolimus-coated balloons in injured superficial femoral arteries of the familial hypercholesterolemic Swine. Circulation. Cardiovascular interventions 20111001
Dual antiplatelet therapy duration and clinical outcomes following treatment with zotarolimus-eluting stents. JACC. Cardiovascular interventions 20111001
Will we ever know the optimal duration of dual antiplatelet therapy after drug-eluting stent implantation? JACC. Cardiovascular interventions 20111001
Real world clinical performance of the zotarolimus eluting coronary stent system in Chinese patients: a prospective, multicenter registry study. Chinese medical journal 20111001
Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients. Heart (British Cardiac Society) 20110901
[Zotarolimus-eluting stent]. Nihon rinsho. Japanese journal of clinical medicine 20110901
Polymer-free sirolimus- and probucol-eluting versus new generation zotarolimus-eluting stents in coronary artery disease: the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol-Eluting versus Zotarolimus-eluting Stents (ISAR-TEST 5) trial. Circulation 20110802
Should stent selection in diabetic patients be considered as a special case? EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20110701
Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20110701
Impact of drug release kinetics on vascular response to different zotarolimus-eluting stents implanted in patients with long coronary stenoses: the LongOCT study (Optical Coherence Tomography in Long Lesions). JACC. Cardiovascular interventions 20110701
Linking drug-eluting stent kinetics and clinical outcomes: insights from optical coherence tomography. JACC. Cardiovascular interventions 20110701
Extended follow-up safety and effectiveness of the Endeavor zotarolimus-eluting stent in real-world clinical practice: two-year follow-up from the E-Five Registry. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110601
Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation. Heart (British Cardiac Society) 20110601
Impact of polymer formulations on neointimal proliferation after zotarolimus-eluting stent with different polymers: insights from the RESOLUTE trial. Circulation. Cardiovascular interventions 20110601
Comparison of titanium-nitride-oxide-coated stents with zotarolimus-eluting stents for coronary revascularization a randomized controlled trial. JACC. Cardiovascular interventions 20110601
The impact of patient and lesion complexity on clinical and angiographic outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial (a randomized comparison of a zotarolimus-eluting stent with an everolimus-eluting stent for percutaneous coronary intervention). Journal of the American College of Cardiology 20110531
Clinical outcomes by geographic region for patients implanted with the zotarolimus-eluting stent. Arquivos brasileiros de cardiologia 20110501
Rationale and design of the clinical evaluation of the Resolute Zotarolimus-Eluting Coronary Stent System in the treatment of de novo lesions in native coronary arteries (the RESOLUTE US clinical trial). American heart journal 20110501
Late-term clinical outcomes with zotarolimus- and sirolimus-eluting stents. 5-year follow-up of the ENDEAVOR III (A Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). JACC. Cardiovascular interventions 20110501
My stent is better than your stent...Or is it? JACC. Cardiovascular interventions 20110501
Clinical evaluation of the Resolute zotarolimus-eluting coronary stent system in the treatment of de novo lesions in native coronary arteries: the RESOLUTE US clinical trial. Journal of the American College of Cardiology 20110426
Clinical outcome, angiographic outcome, and coronary endothelial function after drug-eluting stent implantation. Journal of the American College of Cardiology 20110412
Unrestricted randomised use of two new generation drug-eluting coronary stents: 2-year patient-related versus stent-related outcomes from the RESOLUTE All Comers trial. Lancet (London, England) 20110409
Long-term safety and efficacy of drug-eluting stents. Lancet (London, England) 20110409
Novel approaches for preventing or limiting events in diabetic patients (Naples-diabetes) trial: a randomized comparison of 3 drug-eluting stents in diabetic patients. Circulation. Cardiovascular interventions 20110401
Comparison of zotarolimus-eluting stents with sirolimus-eluting and paclitaxel-eluting stents: intimal hyperplasia and vascular changes assessed by volumetric intravascular ultrasound analysis. Circulation. Cardiovascular interventions 20110401
The prognostic utility of the SYNTAX score on 1-year outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial. JACC. Cardiovascular interventions 20110401
Stent fracture and restenosis after zotarolimus-eluting stent implantation. International journal of cardiology 20110303
Comparative assessment of mammalian target of rapamycin inhibitor-eluting stents in the treatment of coronary artery bifurcation lesions: the CASTOR-Bifurcation registry. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110301
Spatial distribution of neo-intimal hyperplasia 6 months after zotarolimus-eluting stent implantation, analysed by optical coherence tomography. Archives of cardiovascular diseases 20110301
A prospective multicenter parallel-controlled trial of TIVOLI biodegradable-polymer-based sirolimus-eluting stent compared to ENDEAVOR zotarolimus-eluting stent for the treatment of coronary artery disease: 8-month angiographic and 2-year clinical follow-up results. Chinese medical journal 20110301
[Determination of the content of zotarolimus on the drug eluting stents by HPLC]. Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation 20110301
Procedural and clinical evaluation of the novel zotarolimus-eluting resolute stent in patients with unselected bifurcated coronary stenosis treated by provisional approach: a multicenter registry. The Journal of invasive cardiology 20110201
Resolute™ drug-eluting stent: a resolution for bifurcation lesions? The Journal of invasive cardiology 20110201
[Types and characteristic features of drug-eluting stents]. Nihon rinsho. Japanese journal of clinical medicine 20110201
Drug-eluting stents for the treatment of pulmonary vein stenosis after atrial fibrillation ablation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110101
The relationship between late lumen loss and restenosis among various drug-eluting stents: a systematic review and meta-regression analysis of randomized clinical trials. Atherosclerosis 20110101
Two-year outcome of Turkish patients treated with Zotarolimus versus Paclitaxel eluting stents in an unselected population with coronary artery disease in the real world: a prospective non-randomized registry in southern Turkey. International journal of medical sciences 20110101
The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study. Cardiovascular revascularization medicine : including molecular interventions 20110101
The impact of new generation drug-eluting stent implantation on patients with chronic kidney disease and a single lesion in the proximal segment of the left anterior descending artery. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101
Comparison of paclitaxel-, sirolimus-, and zotarolimus-eluting stents in patients with acute ST-segment elevation myocardial infarction and metabolic syndrome. Circulation journal : official journal of the Japanese Circulation Society 20110101
Cellular and molecular changes associated with inhibitory effect of pioglitazone on neointimal growth in patients with type 2 diabetes after zotarolimus-eluting stent implantation. Arteriosclerosis, thrombosis, and vascular biology 20101201
Long-term clinical outcomes with zotarolimus-eluting versus bare-metal coronary stents. JACC. Cardiovascular interventions 20101201
Sex-specific outcomes following revascularization with zotarolimus-eluting stents: comparison of angiographic and late-term clinical results. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101115
Gender medicine and drug eluting coronary stents. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101115
Comparison of vascular response to zotarolimus-eluting stent vs paclitaxel-eluting stent implantation: pooled IVUS results from the ZoMaxx I and II trials. Circulation journal : official journal of the Japanese Circulation Society 20101101
Three-month dual antiplatelet therapy after implantation of zotarolimus-eluting stents: the DATE (Duration of Dual Antiplatelet Therapy AfterImplantation of Endeavor Stent) registry. Circulation journal : official journal of the Japanese Circulation Society 20101101
Long-term follow-up of the randomised controlled trial to evaluate the safety and efficacy of the zotarolimus-eluting driver coronary stent in de novo native coronary artery lesions: five year outcomes in the ENDEAVOR II study. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20101101
Neovascular microchannels in sirolimus-eluting stent occlusion at late phase. JACC. Cardiovascular interventions 20101101
Comparison of zotarolimus-eluting stents with sirolimus- and paclitaxel-eluting stents for coronary revascularization: the ZEST (comparison of the efficacy and safety of zotarolimus-eluting stent with sirolimus-eluting and paclitaxel-eluting stent for coronary lesions) randomized trial. Journal of the American College of Cardiology 20101005
Short- and mid-term intravascular ultrasound analysis of the new zotarolimus-eluting stent with durable polymer – results from the RESOLUTE trial –. Circulation journal : official journal of the Japanese Circulation Society 20101001
Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial. Heart (British Cardiac Society) 20101001
Paclitaxel-coated balloons - Survey of preclinical data. Minerva cardioangiologica 20101001
Two-year clinical outcomes after large coronary stent (4.0 mm) placement: comparison of bare-metal stent versus drug-eluting stent. Clinical cardiology 20101001
Improved late clinical safety with zotarolimus-eluting stents compared with paclitaxel-eluting stents in patients with de novo coronary lesions: 3-year follow-up from the ENDEAVOR IV (Randomized Comparison of Zotarolimus- and Paclitaxel-Eluting Stents in Patients With Coronary Artery Disease) trial. JACC. Cardiovascular interventions 20101001
Comparison of zotarolimus-eluting and everolimus-eluting coronary stents. The New England journal of medicine 20100708
Development and performance of the zotarolimus-eluting Endeavor coronary stent. Expert review of medical devices 20100701
Twelve-month outcomes in patients with diabetes implanted with a zotarolimus-eluting stent: results from the E-Five Registry. Heart (British Cardiac Society) 20100601
Procedure-related myonecrosis after bare and drug-eluting stent implantation. Asian cardiovascular & thoracic annals 20100601
Clinical and angiographic outcomes of drug-eluting stents in patients with large vessel and single coronary artery lesion. Clinical cardiology 20100601
A randomised comparison of novolimus-eluting and zotarolimus-eluting coronary stents: 9-month follow-up results of the EXCELLA II study. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20100601
Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study. JACC. Cardiovascular interventions 20100601
The initial extent of malapposition in ST-elevation myocardial infarction treated with drug-eluting stent: the usefulness of optical coherence tomography. Yonsei medical journal 20100501
Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents. JACC. Cardiovascular interventions 20100501
Eighteen-month clinical safety and efficacy outcomes of sirolimus-, paclitaxel- and zotarolimus-drug eluting stents in diabetic patients undergoing percutaneous coronary intervention for complex coronary artery stenosis. Annals of the Academy of Medicine, Singapore 20100501
In-hospital and 12-month postprocedural clinical outcome of coronary bifurcational lesion treatment with the endeavor stent. Journal of interventional cardiology 20100401
Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial. Lancet (London, England) 20100327
Sorting out drug-eluting stents. Lancet (London, England) 20100327
Comparison of outcomes between Zotarolimus- and sirolimus-eluting stents in patients with ST-segment elevation acute myocardial infarction. The American journal of cardiology 20100315
A randomized comparison of the Endeavor zotarolimus-eluting stent versus the TAXUS paclitaxel-eluting stent in de novo native coronary lesions 12-month outcomes from the ENDEAVOR IV trial. Journal of the American College of Cardiology 20100209
Cost-effectiveness of the Endeavor stent in de novo native coronary artery lesions updated with contemporary data. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20100201
Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents. European heart journal 20100101
Small coronary vessel angioplasty: outcomes and technical considerations. Vascular health and risk management 20100101
Clinical studies with sirolimus, zotarolimus, everolimus, and biolimus A9 drug-eluting stent systems. Current pharmaceutical design 20100101
Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents. The American journal of cardiology 20091215
Structural identification and characterization of potential degradants of zotarolimus on zotarolimus-coated drug-eluting stents. Journal of pharmaceutical and biomedical analysis 20091205
Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents. Heart (British Cardiac Society) 20091201
Lack of clinical benefit of improved angiographic results with sirolimus-eluting stents compared with paclitaxel and zotarolimus-eluting stents in patients with acute myocardial infarction undergoing percutaneous coronary intervention. Circulation journal : official journal of the Japanese Circulation Society 20091201
Five-year clinical follow-up after implantation of the Endeavor zotarolimus-eluting stent: ENDEAVOR I, first-in-human study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091201
The long-term results of the 'Endeavor' stent. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091201
Rationale and design of the Patient Related OuTcomes with Endeavor versus Cypher stenting Trial (PROTECT): randomized controlled trial comparing the incidence of stent thrombosis and clinical events after sirolimus or zotarolimus drug-eluting stent implantation. American heart journal 20091201
Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). JACC. Cardiovascular interventions 20091201
Late safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent compared with a paclitaxel-eluting stent in patients with de novo coronary lesions: 2-year follow-up from the ENDEAVOR IV trial (Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). JACC. Cardiovascular interventions 20091201
Safety and effectiveness of the Endeavor zotarolimus-eluting stent in real-world clinical practice: 12-month data from the E-Five registry. JACC. Cardiovascular interventions 20091201
Evaluation in 3 months duration of neointimal coverage after zotarolimus-eluting stent implantation by optical coherence tomography: the ENDEAVOR OCT trial. JACC. Cardiovascular interventions 20091201
Comparison of the efficacy and safety of zotarolimus-, sirolimus-, and paclitaxel-eluting stents in patients with ST-elevation myocardial infarction. The American journal of cardiology 20091115
Clinical and angiographic outcomes in diabetics from the ENDEAVOR IV trial: randomized comparison of zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease. JACC. Cardiovascular interventions 20091001
Clinical and angiographic results with the next-generation resolute stent system: a prospective, multicenter, first-in-human trial. JACC. Cardiovascular interventions 20091001
A generation 2.5 drug-eluting stent? JACC. Cardiovascular interventions 20091001
Intravascular ultrasound results from the ENDEAVOR IV trial: randomized comparison between zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease. JACC. Cardiovascular interventions 20090801
Angiographic and intravascular ultrasound findings following implantation of the Endeavor zotarolimus-eluting stents in patients from the real-world clinical practice. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090801
Different vascular response to concurrent implantation of sirolimus- and zotarolimus-eluting stents in the same vessel. Heart and vessels 20090701
A prospective, randomized, 6-month comparison of the coronary vasomotor response associated with a zotarolimus- versus a sirolimus-eluting stent: differential recovery of coronary endothelial dysfunction. Journal of the American College of Cardiology 20090505
Differences in restenosis rate with different drug-eluting stents in patients with and without diabetes mellitus: a report from the SCAAR (Swedish Angiography and Angioplasty Registry). Journal of the American College of Cardiology 20090505
Correlation between quantitative angiographic and intravascular ultrasound parameters in patients treated with sirolimus analogous-eluting stents. The international journal of cardiovascular imaging 20090401
Zotarolimus for the treatment of coronary artery disease: pathophysiology, DES design, clinical evaluation and future perspective. Expert opinion on pharmacotherapy 20090401
Frequency and clinical consequences associated with sidebranch occlusion during stent implantation using zotarolimus-eluting and paclitaxel-eluting coronary stents. Circulation. Cardiovascular interventions 20090401
Optical coherence tomography to diagnose under-expansion of a drug-eluting stent. JACC. Cardiovascular imaging 20090201
Long-term follow-up of percutaneous coronary intervention of unprotected left main lesions with drug eluting stents: predictors of clinical outcome. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090101
[Economic evaluation and budget impact analysis of the Endeavor drug-eluting stent in Spain]. Gaceta sanitaria 20090101
Comparative analysis of neointimal coverage with paclitaxel and zotarolimus drug-eluting stents, using optical coherence tomography 6 months after implantation. Archives of cardiovascular diseases 20090101
Fracture of zotarolimus-eluting stent after implantation. Texas Heart Institute journal 20090101
Is there a preferable DES in diabetic patients? A critical appraisal of the evidence. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20081201
Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses. Circulation. Cardiovascular interventions 20081201
Long-term coronary endothelial function after zotarolimus-eluting stent implantation. A 9 month comparison between zotarolimus-eluting and sirolimus-eluting stents. International heart journal 20081101
Long-term safety and efficacy are observed after implantation of Zotarolimus-Eluting stent in real-world clinical practice. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20081101
Everolimus- and zotarolimus-eluting stents for bare metal stent in-stent restenosis treatment: a prospective study. Journal of interventional cardiology 20081001
A randomized, controlled, multicenter trial to evaluate the safety and efficacy of zotarolimus- versus paclitaxel-eluting stents in de novo occlusive lesions in coronary arteries The ZoMaxx I trial. JACC. Cardiovascular interventions 20081001
The process of bringing new drug-eluting stents to market will they see the light of day? JACC. Cardiovascular interventions 20081001
Angioscopic comparison of neointimal coverage between zotarolimus- and sirolimus-eluting stents. Journal of the American College of Cardiology 20080826
Coexistent in-stent restenosis, late incomplete stent apposition and mural thrombus in a zotarolimus-eluting stent. The Journal of invasive cardiology 20080801
Endothelial cell recovery between comparator polymer-based drug-eluting stents. Journal of the American College of Cardiology 20080729
Angiographic time course of in-stent restenosis with zotarolimus drug-eluting stents. The Canadian journal of cardiology 20080701
Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent. Journal of biomedical materials research. Part A 20080615
Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel meeting on the endeavor zotarolimus-eluting coronary stent. Circulation 20080325
Successful percutaneous treatment of an intraprocedural left main stent thrombosis with the support of an automatic mechanical chest compression device. International journal of cardiology 20080227
Sirolimus, Tacrolimus and Zotarolimus eluting stents to treat bifurcated lesions: a 7-month clinical outcome comparison. Minerva cardioangiologica 20080201
Future stent drug delivery systems. Minerva cardioangiologica 20080201
Comparison of vascular response to zotarolimus-eluting stent versus sirolimus-eluting stent: intravascular ultrasound results from ENDEAVOR III. American heart journal 20080101
A preliminary experience report: Drug-eluting stents versus coronary artery bypass surgery in patients with a single lesion in the proximal left anterior descending artery suffering from diabetes mellitus and chronic stable angina. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20080101
Meta-analysis shows similar risk of thrombosis after drug-eluting stent, bare-metal stent, or angioplasty. Endothelium : journal of endothelial cell research 20080101
Clinical results of drug eluting stents compared to bare metal stents for patients with ST elevation acute myocardial infarction. Acute cardiac care 20080101
Drug eluting stents versus coronary artery bypass surgery in patients with isolated proximal lesion in left anterior descending artery suffering from chronic stable angina. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071115
The significance of preclinical evaluation of sirolimus-, paclitaxel-, and zotarolimus-eluting stents. The American journal of cardiology 20071022
Zotarolimus-eluting stents in patients with native coronary artery disease: clinical and angiographic outcomes in 1,317 patients. The American journal of cardiology 20071022
Four-year clinical follow-up after implantation of the endeavor zotarolimus-eluting stent: ENDEAVOR I, the first-in-human study. The American journal of cardiology 20071022
The relation between clinical features, angiographic findings, and the target lesion revascularization rate in patients receiving the endeavor zotarolimus-eluting stent for treatment of native coronary artery disease: an analysis of ENDEAVOR I, ENDEAVOR II, ENDEAVOR II Continued Access Registry, and ENDEAVOR III. The American journal of cardiology 20071022
Intravascular ultrasound findings in ENDEAVOR II and ENDEAVOR III. The American journal of cardiology 20071022
Real-world safety and efficacy of the endeavor zotarolimus-eluting stent: early data from the E-Five Registry. The American journal of cardiology 20071022
Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: application to active pharmaceutical ingredient process development. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Late vascular response at the edges of sirolimus analogous-eluting stents in diabetic patients: An intravascular ultrasound study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071001
Determination of sirolimus in rabbit arteries using liquid chromatography separation and tandem mass spectrometric detection. Biomedical chromatography : BMC 20071001
The application of ink-jet technology for the coating and loading of drug-eluting stents. Annals of biomedical engineering 20071001
The pros and cons of living on the edge. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071001
A randomized comparison of sirolimus-eluting stent implantation with zotarolimus-eluting stent implantation for the treatment of total coronary occlusions: rationale and design of the PRImary Stenting of Occluded Native coronary arteries III (PRISON III) study. American heart journal 20070901
Detailed intravascular ultrasound analysis of Zotarolimus-eluting phosphorylcholine-coated cobalt-chromium alloy stent in de novo coronary lesions (results from the ENDEAVOR II trial). The American journal of cardiology 20070901
[Relationship between plasma C-reactive protein level and neointimal hyperplasia volume in patients with zotarolimus-eluting stents. Volumetric analysis by three-dimensional intracoronary ultrasound]. Revista espanola de cardiologia 20070901
Clinical impact of in-stent late loss after drug-eluting coronary stent implantation. European heart journal 20070701
Modified T-stenting with intentional protrusion of the side-branch stent within the main vessel stent to ensure ostial coverage and facilitate final kissing balloon: the T-stenting and small protrusion technique (TAP-stenting). Report of bench testing and first clinical Italian-Korean two-centre experience. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20070701
A three-dimensional intravascular ultrasound comparison between the new zotarolimus-eluting stent (ZoMaxx) and the non-drug-eluting TriMaxx stent. The Journal of invasive cardiology 20070701
Percutaneous coronary revascularization using a trilayer metal phosphorylcholine-coated zotarolimus-eluting stent. The American journal of cardiology 20070515
Accurate determination of an immunosuppressant in stented swine tissues with LC-MS/MS. Analytical and bioanalytical chemistry 20070401
Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression. Journal of cardiovascular pharmacology 20070401
Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions. Clinical and angiographic results of the ENDEAVOR II Trial. Minerva cardioangiologica 20070201
TCT Daily: ZOMAXX I--mixed results with zotarolimus-eluting stent. Journal of interventional cardiology 20070201
Dilemma of drug-eluting stent implantation in a patient with systemic lupus erythematosus. International journal of cardiology 20070118
XIENCE V everolimus-eluting coronary stent system: a novel second generation drug-eluting stent. Expert review of medical devices 20070101
Do the benefits outweigh the risks with drug-eluting stents? Scandinavian cardiovascular journal : SCJ 20070101
Newer stents: looking at the horizon. Indian heart journal 20070101
Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial. Journal of the American College of Cardiology 20061219
Overview of pharmacology and clinical trials program with the zotarolimus-eluting endeavor stent. Journal of interventional cardiology 20061001
Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions: clinical and angiographic results of the ENDEAVOR II trial. Circulation 20060822
Zotarolimus (ABT-578) eluting stents. Advanced drug delivery reviews 20060603
Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks. European heart journal 20060401
Method development and validation for zotarolimus concentration determination in stented swine arteries by liquid chromatography/tandem mass spectrometry detection. Rapid communications in mass spectrometry : RCM 20060101
Subacute thrombosis following implantation of zotarolimus-eluting stent. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20060101
Rapamycin analogs with reduced systemic exposure. Bioorganic & medicinal chemistry letters 20051201
Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples. Therapeutic drug monitoring 20051201
Technology Insight: an overview of research in drug-eluting stents. Nature clinical practice. Cardiovascular medicine 20051201
A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects. Journal of clinical pharmacology 20050801
Stent-based delivery of ABT-578 via a phosphorylcholine surface coating reduces neointimal formation in the porcine coronary model. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20050601
96-Well liquid-liquid extraction liquid chromatography-tandem mass spectrometry method for the quantitative determination of ABT-578 in human blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605
ABT-578-eluting stents. The promising successor of sirolimus- and paclitaxel-eluting stent concepts? Herz 20040301
Method development for the quantitation of ABT-578 in rabbit artery tissue by 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometric detection. Rapid communications in mass spectrometry : RCM 20040101
Properties