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Azd0865

CAS No.:
248919-64-4
Catalog Number:
AG00BF77
Molecular Formula:
C21H26N4O2
Molecular Weight:
366.4567
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$182
- +
10mg
98%
1 week
United States
$265
- +
25mg
98%
1 week
United States
$473
- +
50mg
98%
1 week
United States
$682
- +
100mg
98%
1 week
United States
$1029
- +
Product Description
Catalog Number:
AG00BF77
Chemical Name:
Azd0865
CAS Number:
248919-64-4
Molecular Formula:
C21H26N4O2
Molecular Weight:
366.4567
MDL Number:
MFCD30343852
IUPAC Name:
8-[(2,6-dimethylphenyl)methylamino]-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
InChI:
InChI=1S/C21H26N4O2/c1-13-6-5-7-14(2)18(13)11-23-19-10-17(21(27)22-8-9-26)12-25-16(4)15(3)24-20(19)25/h5-7,10,12,23,26H,8-9,11H2,1-4H3,(H,22,27)
InChI Key:
GHVIMBCFLRTFHI-UHFFFAOYSA-N
SMILES:
OCCNC(=O)c1cc(NCc2c(C)cccc2C)c2n(c1)c(C)c(n2)C
UNII:
E0OU4SC8DP
Properties
Complexity:
493  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
366.206g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
366.465g/mol
Monoisotopic Mass:
366.206g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
78.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4  
Literature
Title Journal
Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20120601
Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs). Bioorganic & medicinal chemistry letters 20091201
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs). Bioorganic & medicinal chemistry letters 20090701
A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease. The American journal of gastroenterology 20080101
New pharmacological agents for the treatment of gastroesophageal reflux disease. Reviews in gastroenterological disorders 20080101
[Therapeutic innovations in gastroesophageal reflux]. Presse medicale (Paris, France : 1983) 20071201
A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071201
Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochemical pharmacology 20070115
Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands. American journal of physiology. Gastrointestinal and liver physiology 20061101
Properties