Home Other Building Blocks Lasalocid

Lasalocid

CAS No.:
25999-31-9
Catalog Number:
AG00BF65
Molecular Formula:
C34H54O8
Molecular Weight:
590.7878
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$250
- +
25mg
≥98%
1 week
United States
$780
- +
Product Description
Catalog Number:
AG00BF65
Chemical Name:
Lasalocid
CAS Number:
25999-31-9
Molecular Formula:
C34H54O8
Molecular Weight:
590.7878
MDL Number:
MFCD00242774
IUPAC Name:
6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-3-methyloxolan-2-yl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid
InChI:
InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1
InChI Key:
BBMULGJBVDDDNI-OWKLGTHSSA-N
SMILES:
CC[C@@H](C(=O)[C@H]([C@H]([C@@H](CCc1ccc(c(c1C(=O)O)O)C)C)O)C)[C@H]1O[C@](C[C@@H]1C)(CC)[C@H]1CC[C@]([C@@H](O1)C)(O)CC
EC Number:
247-401-9
UNII:
W7V2ZZ2FWB
Properties
Complexity:
910  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
590.382g/mol
Formal Charge:
0
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
590.798g/mol
Monoisotopic Mass:
590.382g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
134A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.4  
Literature
Title Journal
Structural characterization of polyketides using high mass accuracy tandem mass spectrometry. Analytical chemistry 20121016
Development of a five-plex flow cytometric immunoassay for the simultaneous detection of six coccidiostats in feed and eggs. Analytical and bioanalytical chemistry 20120901
Assessment of dietary supplementation with probiotics on performance, intestinal morphology and microflora of chickens infected with Eimeria tenella. Veterinary parasitology 20120813
Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis. Journal of the American Chemical Society 20120502
Biochemistry: favouring the unfavoured. Nature 20120314
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature 20120304
Simultaneous determination of five polyether ionophores using liquid chromatography with one-step fluorescent derivatization. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20120101
Determination of lasalocid residues in the tissues of broiler chickens by liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
Acute and long-term cardiomyopathy and delayed neurotoxicity after accidental lasalocid poisoning in horses. Journal of veterinary internal medicine 20120101
'Human babesiosis': an emerging transfusion dilemma. International journal of hepatology 20120101
An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology 20120101
Tissue Doppler imaging and 2-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid. Journal of veterinary internal medicine 20120101
Quantification of ionophores in aged poultry litter using liquid chromatography tandem mass spectrometry. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20120101
Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
Determination of narasin and monensin in bovine, swine, and chicken tissues by liquid chromatography with tandem mass spectrometry: first action 2011.24. Journal of AOAC International 20120101
Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry. Journal of AOAC International 20120101
Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action. PloS one 20120101
Insights into lasalocid A ring formation by chemical chain termination in vivo. Angewandte Chemie (International ed. in English) 20111209
Development and validation of an UPLC-MS/MS method for the determination of ionophoric and synthetic coccidiostats in vegetables. Analytical and bioanalytical chemistry 20111201
Rapid quantification of ionophores in feeds by liquid chromatography-tandem mass spectrometry. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20110901
Determination of eleven coccidiostats in animal feed by liquid chromatography-tandem mass spectrometry at cross contamination levels. Analytica chimica acta 20110826
Development and validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for eleven coccidiostats in eggs. Analytica chimica acta 20110826
Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis. Organic letters 20110401
Acute lasalocid poisoning in calves associated with off-label use. Journal of veterinary pharmacology and therapeutics 20110401
Rapid and reliable identification of ionophore antibiotics in feeds by liquid chromatography-tandem mass spectrometry. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20110301
The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites. Avian diseases 20110301
Pediococcus acidilactici isolated from the rumen of lambs with rumen acidosis, 16S rRNA identification and sensibility to monensin and lasalocid. Research in veterinary science 20110201
Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters. The Journal of antibiotics 20110101
A new approach to the analysis of nicarbazin and ionophores in eggs by HPLC/MS/MS. Journal of AOAC International 20110101
[Simultaneous determination of polyether antibiotics and macrolide anthelmintics in livestock products by liquid chromatography/tandem mass spectrometry]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20110101
Simultaneous determination of polyether ionophores, macrolides and lincosamides in hen eggs by liquid chromatography-electrospray ionization tandem mass spectrometry using a simple solvent extraction. Analytica chimica acta 20101203
Evaluation of potential carryover effects associated with limit feeding of gravid Holstein heifers. Journal of dairy science 20101101
Selection of single chain variable fragment (scFv) antibodies from a hyperimmunized phage display library for the detection of the antibiotic monensin. Journal of immunological methods 20100831
Lasalocid awareness and sampling in Scotland. International journal of environmental health research 20100601
Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A. Organic letters 20100521
An unusual thioesterase promotes isochromanone ring formation in ajudazol biosynthesis. Chembiochem : a European journal of chemical biology 20100517
Direct aqueous supercritical fluid extraction coupled on-line with liquid chromatography-tandem mass spectrometry for the analysis of polyether ionophore antibiotics in water. Journal of chromatography. A 20100514
The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model. Avian pathology : journal of the W.V.P.A 20100201
Synthesis of marine polycyclic polyethers via endo-selective epoxide-opening cascades. Marine drugs 20100101
Retrospective study of salinomycin toxicosis in 66 cats. Veterinary medicine international 20100101
Inhaled Anesthetics Promote Albumin Dimerization through Reciprocal Exchange of Subdomains. Biochemistry research international 20100101
Validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for 10 anticoccidials in eggs according to Commission Decision 2002/657/EC. Journal of chromatography. A 20091113
Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry. Journal of chromatography. A 20091113
The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review. Poultry science 20091101
[Determination of 5 polyether antibiotics in chicken tissues by liquid chromatography-electrospray ionization tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20091101
Effects of organophosphate phenyl saligenin phosphate and polyether carboxylic ionophore lasalocid on motor nerve conduction velocity, neuropathy target esterase enzyme activity, and clinical ataxia in chickens. Toxicology mechanisms and methods 20090601
Effects of ionophores and antibiotics on in vitro hydrogen sulfide production, dry matter disappearance, and total gas production in cultures with a steam-flaked corn-based substrate with or without added sulfur. Journal of animal science 20090501
Fast liquid chromatography/multiple-stage mass spectrometry of coccidiostats. Rapid communications in mass spectrometry : RCM 20090501
Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Bioscience, biotechnology, and biochemistry 20090101
Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture. Gut pathogens 20090101
Responses of plasma acetate metabolism to hop (Humulus lupulus L.) in sheep. International journal of biological sciences 20090101
Giardia duodenalis in feedlot cattle from the central and western United States. BMC veterinary research 20090101
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European journal of chemical biology 20081215
Efficacy of lasalocid against coccidiosis in Chinese ring-necked pheasants. Avian diseases 20081201
Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis. Journal of the American Chemical Society 20080917
Determination of ionophore coccidiostats in feedingstuffs by liquid chromatography-tandem mass spectrometry Part I. Application to targeted feed. Journal of pharmaceutical and biomedical analysis 20080805
Doubly compensated multiplicity-edited HSQC experiments utilizing broadband inversion pulses. Magnetic resonance in chemistry : MRC 20080701
Antimicrobial use on 24 beef farms in Ontario. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080301
Determination of lasalocid sodium in animal feeds and premixes by reversed-phase liquid chromatography: collaborative study. Journal of AOAC International 20080101
Rubidium(I) monensinate dihydrate. Acta crystallographica. Section E, Structure reports online 20080101
Effects of lasalocid or monensin supplementation on digestion, ruminal fermentation, blood metabolites, and milk production of lactating dairy cows. Journal of dairy science 20071201
Sorption and degradation in soils of veterinary ionophore antibiotics: monensin and lasalocid. Environmental toxicology and chemistry 20070801
Mucosal mast cell proteases are involved in colonic permeability alterations and subsequent bacterial translocation in endotoxemic rats. Shock (Augusta, Ga.) 20070701
Changes in net portal nutrient flux in response to weaning transition and ionophore supplementation in dairy calves. Journal of dairy science 20070301
Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae). Acta veterinaria Hungarica 20070301
Effects of weaning and ionophore supplementation on selected blood metabolites and growth in dairy calves. Journal of dairy science 20060901
Efficacy of ionophores in cattle diets for mitigation of enteric methane. Journal of animal science 20060701
Simultaneous determination of four coccidiostats in eggs and broiler meat: validation of an LC-MS/MS method. Food additives and contaminants 20060501
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular neurodegeneration 20060101
Effect of ionophore supplementation on the incidence of Escherichia coli O157:H7 and Salmonella and antimicrobial susceptibility of fecal coliforms in Stocker cattle. Foodborne pathogens and disease 20060101
An Irish perspective on Cryptosporidium. Part 2. Irish veterinary journal 20060101
Incidence of residues of nine anticoccidials in eggs. Food additives and contaminants 20051101
The solution structure of a lasalocid A metal complex in lipophilic solvents. Bioorganic & medicinal chemistry 20050901
[Cryptosporidiosis in newborn calves in Ankara region: clinical, haematological findings and treatment with Lasalocid-NA]. DTW. Deutsche tierarztliche Wochenschrift 20050601
A band-selective composite gradient: application to DQF-COSY. Journal of magnetic resonance (San Diego, Calif. : 1997) 20050501
A comparison of data analysis methods for determining gas phase stabilities by CID: alkali metal complexes of polyether ionophore antibiotics. Journal of the American Society for Mass Spectrometry 20050501
Comparison of copper speciation in estuarine water measured using analytical voltammetry and supported liquid membrane techniques. Environmental science & technology 20050501
Periodicity in collision-induced and remote-bond activation of alkali metal ions attached to polyether ionophores. The Analyst 20050401
The residue levels of narasin in eggs of laying hens fed with unmedicated and medicated feed. Molecular nutrition & food research 20050101
Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
Extending the limits of the selective 1D NOESY experiment with an improved selective TOCSY edited preparation function. Journal of magnetic resonance (San Diego, Calif. : 1997) 20041201
Development of multiclass methods for drug residues in eggs: silica SPE cleanup and LC-MS/MS analysis of ionophore and macrolide residues. Journal of agricultural and food chemistry 20041117
Ionophore taste preferences of dairy heifers. Journal of animal science 20041101
Production and health of pasture-fed dairy cattle following oral treatment with the ionophore lasalocid. Journal of dairy science 20040901
Accidental poisoning of 17 dogs with lasalocid. The Veterinary record 20040807
[Development of monoclonal-based enzyme-linked immunosorbent assay and immunochromatographic assay for lasalocid and semduramicin]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20040601
Isolation and selection of ionophore-tolerant Eimeria precocious lines: E. tenella, E. maxima and E. acervulina. Veterinary parasitology 20040206
Susceptibility of Clostridium perfringens strains from broiler chickens to antibiotics and anticoccidials. Avian pathology : journal of the W.V.P.A 20040201
An alternative to antibiotic-based drugs in feed for enhancing performance of broilers grown on Eimeria spp.-infected litter. Poultry science 20040101
Rapid forensic selected reaction monitoring liquid chromatography/mass spectrometry determination of ionophore antibiotics found at toxic levels in animal feeds. Journal of AOAC International 20040101
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. Avian diseases 20040101
Effect of lasalocid on growth, blood gases, and nutrient utilization in dairy goats fed a high forage, low protein diet. Journal of dairy science 20031201
The susceptibility of ionophore-resistant Clostridium aminophilum F to other antibiotics. The Journal of antimicrobial chemotherapy 20031001
Suspected lasalocid poisoning in three dogs. Veterinary and human toxicology 20031001
Ionophores: their use as ruminant growth promotants and impact on food safety. Current issues in intestinal microbiology 20030901
Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001. Avian pathology : journal of the W.V.P.A 20030801
Guanidinium receptors as enantioselective amino acid membrane carriers. Journal of the American Chemical Society 20030709
Effects of lasalocid on circulating concentrations of leptin and insulin-like growth factor-I and reproductive performance of postpartum Brahman cows. Journal of animal science 20030601
Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella. Archiv fur Tierernahrung 20030401
Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro. Journal of applied microbiology 20030101
A functional observational battery for use in canine toxicity studies: development and validation. International journal of toxicology 20030101
Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations. Biopolymers 20021015
[Effects of veterinary drugs on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20021001
Fragmentation studies on lasalocid acid by accurate mass electrospray mass spectrometry. The Analyst 20020901
Use of an adsorbed chiral selector in capillary LC-MS. Chirality 20020801
Lasalocid toxicosis is inadequately quantified for horses. Veterinary and human toxicology 20020801
Effect of lonophore supplementation on selected serum constituents of sheep consuming locoweed. Veterinary and human toxicology 20020601
The determination of 5 anticoccidial drugs (nicarbazin, lasalocid, monensin, salinomycin and narasin) in animal livers and eggs by liquid chromatography linked with tandem mass spectrometry (LC-MS-MS). The Analyst 20020601
Improved clean-up for the determination of lasalocid in 'difficult' food matrices. Food additives and contaminants 20020101
Effects of dietary rice bran, lasalocid, and sex of calf on postpartum reproduction in Brahman cows. Journal of animal science 20011201
Secretion of the trefoil factor TFF3 from the isolated vascularly perfused rat colon. Regulatory peptides 20010915
Nutritionally directed compensatory growth enhances heifer development and lactation potential. Journal of dairy science 20010701
Efficacy of diclazuril in comparison with chemical and ionophorous anticoccidials against Eimeria spp. in broiler chickens in floor pens. Poultry science 20010401
Ion pairing between Cl- or ClO4- and alkali metal complexes of ionophore antibiotics in organic solvents: a multinuclear NMR and FT-IR study. Inorganic chemistry 20010326
Improved agar diffusion method for detecting residual antimicrobial agents. Journal of food protection 20010301
7Li-NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution. Biopolymers 20010101
LC/MS confirmation of ionophores in animal feeds. Journal of AOAC International 20010101
Interaction of fluoroquinolones and certain ionophores in broilers: effect on blood levels and hepatic cytochrome p450 monooxygenase activity. Drug metabolism and drug interactions 20010101
Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture. Antimicrobial agents and chemotherapy 20001201
Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer research 20001001
Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. The Journal of antimicrobial chemotherapy 20000301
Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method. FEMS microbiology letters 19990915
In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum. The Journal of antimicrobial chemotherapy 19980201
Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. Antimicrobial agents and chemotherapy 19970101
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. Annals of tropical medicine and parasitology 19961201
Putative anticryptosporidial agents tested with an immunodeficient mouse model. Antimicrobial agents and chemotherapy 19940401
Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats. The Journal of infectious diseases 19931201
Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model. The Journal of infectious diseases 19930301
Inhibitory effects of polyethers on human immunodeficiency virus replication. Antimicrobial agents and chemotherapy 19920201
Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice. The Journal of protozoology 19910101
Anti-cryptosporidial drug activity screened with an immunosuppressed rat model. The Journal of protozoology 19910101
Properties