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Cp-4126

CAS No.:
210829-30-4
Catalog Number:
AG00BF61
Molecular Formula:
C27H43F2N3O5
Molecular Weight:
527.6442
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$232
- +
10mg
99%
1 week
United States
$298
- +
50mg
99%
1 week
United States
$798
- +
Product Description
Catalog Number:
AG00BF61
Chemical Name:
Cp-4126
CAS Number:
210829-30-4
Molecular Formula:
C27H43F2N3O5
Molecular Weight:
527.6442
MDL Number:
MFCD15145214
IUPAC Name:
[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl (E)-octadec-9-enoate
InChI:
InChI=1S/C27H43F2N3O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(33)36-20-21-24(34)27(28,29)25(37-21)32-19-18-22(30)31-26(32)35/h9-10,18-19,21,24-25,34H,2-8,11-17,20H2,1H3,(H2,30,31,35)/b10-9+/t21-,24-,25-/m1/s1
InChI Key:
HESSNRGIEVBPRB-QDDPNBLJSA-N
SMILES:
CCCCCCCC/C=C/CCCCCCCC(=O)OC[C@H]1O[C@H](C([C@@H]1O)(F)F)n1ccc(nc1=O)N
UNII:
231C73W7LG
Properties
Complexity:
803  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
1  
Exact Mass:
527.317g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
527.654g/mol
Monoisotopic Mass:
527.317g/mol
Rotatable Bond Count:
19  
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.2  
Literature
Title Journal
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Investigational new drugs 20121001
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Investigational new drugs 20110601
The activity of the lipophilic nucleoside derivatives elacytarabine and CP-4126 in a panel of tumor cell lines resistant to nucleoside analogues. Nucleosides, nucleotides & nucleic acids 20100601
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. International journal of oncology 20100101
CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines. British journal of haematology 20090101
Properties