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Daf-fm da

CAS No.:
254109-22-3
Catalog Number:
AG00BF5V
Molecular Formula:
C25H18F2N2O7
Molecular Weight:
496.4164
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$500
- +
5mg
≥98%
1 week
United States
$1718
- +
Product Description
Catalog Number:
AG00BF5V
Chemical Name:
Daf-fm da
CAS Number:
254109-22-3
Molecular Formula:
C25H18F2N2O7
Molecular Weight:
496.4164
MDL Number:
MFCD16872050
IUPAC Name:
[6'-acetyloxy-4-amino-2',7'-difluoro-5-(methylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] acetate
InChI:
InChI=1S/C25H18F2N2O7/c1-10(30)33-20-8-18-13(6-15(20)26)25(12-4-5-17(29-3)23(28)22(12)24(32)36-25)14-7-16(27)21(34-11(2)31)9-19(14)35-18/h4-9,29H,28H2,1-3H3
InChI Key:
BEVHTVRRVVEMEF-UHFFFAOYSA-N
SMILES:
CNc1ccc2c(c1N)C(=O)OC12c2cc(F)c(cc2Oc2c1cc(F)c(c2)OC(=O)C)OC(=O)C
Properties
Complexity:
862  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
496.108g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
496.423g/mol
Monoisotopic Mass:
496.108g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
126A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.7  
Literature
Title Journal
Calcium is involved in nitric oxide- and auxin-induced lateral root formation in rice. Protoplasma 20120101
Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cells. Nitric oxide : biology and chemistry 20110531
Reactive oxygen species and nitric oxide mediate actin reorganization and programmed cell death in the self-incompatibility response of papaver. Plant physiology 20110501
Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism. American journal of physiology. Cell physiology 20110101
Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. American journal of physiology. Renal physiology 20101101
Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20100901
Effects of epigallocatechin gallate on rotenone-injured murine brain cultures. Journal of neural transmission (Vienna, Austria : 1996) 20100101
The effects of nitric oxide in settlement and adhesion of zoospores of the green alga Ulva. Biofouling 20100101
Strategies of Nitrosomonas europaea 19718 to counter low dissolved oxygen and high nitrite concentrations. BMC microbiology 20100101
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro. Biochemical pharmacology 20091015
Local and systemic production of nitric oxide in tomato responses to powdery mildew infection. Molecular plant pathology 20090701
Nitric oxide (NO) increase at fertilization in sea urchin eggs upregulates fertilization envelope hardening. Developmental biology 20081015
Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. American journal of physiology. Lung cellular and molecular physiology 20080701
Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology (Baltimore, Md.) 20080401
Measuring NO production by plant tissues and suspension cultured cells. Molecular plant 20080301
Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures. Clinical and experimental pharmacology & physiology 20080201
Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation. Pflugers Archiv : European journal of physiology 20080101
Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats. Hypertension (Dallas, Tex. : 1979) 20071001
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circulation research 20070914
Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe. Free radical biology & medicine 20070815
Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology 20070801
Red blood cell stimulation of platelet nitric oxide production indicated by quantitative monitoring of the communication between cells in the bloodstream. Analytical chemistry 20070715
Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor. FEBS letters 20070529
Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions. The Journal of physiology 20070515
Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology 20070401
Aspects of programmed cell death during early senescence of barley leaves: possible role of nitric oxide. Protoplasma 20070101
Opioid receptor-independent protection of ischemic rat hepatocytes by morphine. Biochemical and biophysical research communications 20061229
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. Journal of applied physiology (Bethesda, Md. : 1985) 20061201
Calcium-dependent release of NO from intracellular S-nitrosothiols. The EMBO journal 20060712
Regulation of nitric oxide production in snail (Lymnaea stagnalis) defence cells: a role for PKC and ERK signalling pathways. Biology of the cell 20060501
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. Molecular pharmacology 20060301
Enhancement of nitric oxide production by association of nitric oxide synthase with N-methyl-D-aspartate receptors via postsynaptic density 95 in genetically engineered Chinese hamster ovary cells: real-time fluorescence imaging using nitric oxide sensitive dye. Journal of neurochemistry 20060301
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia. Journal of molecular and cellular cardiology 20060101
DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin. The Journal of pharmacology and experimental therapeutics 20051101
Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease. Free radical biology & medicine 20051015
Flash photolysis of caged nitric oxide inhibits proximal tubular fluid reabsorption in free-flow nephron. American journal of physiology. Regulatory, integrative and comparative physiology 20050801
On the specificity of 4-amino-5-methylamino-2',7'-difluorofluorescein as a probe for nitric oxide. Free radical biology & medicine 20050801
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. Biochemical pharmacology 20050415
Insulin-stimulated endothelial nitric oxide release is calcium independent and mediated via protein kinase B. Biochemical pharmacology 20050301
The novel red-fluorescent probe DAR-4M measures reactive nitrogen species rather than NO. Journal of pharmacological and toxicological methods 20050101
Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function. American journal of physiology. Heart and circulatory physiology 20041201
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