Treosulfan
| Title | Journal |
|---|---|
| Allo-SCT for AML and MDS with treosulfan compared with BU-based regimens: reduced toxicity vs reduced intensity. | Bone marrow transplantation 20121001 |
| Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning. | Bone marrow transplantation 20120901 |
| Phase II prospective study of treosulfan-based reduced-intensity conditioning in allogeneic HSCT for hematological malignancies from 10/10 HLA-identical unrelated donor. | Annals of hematology 20120801 |
| A prospective multicenter study of treosulfan in elderly patients with recurrent ovarian cancer: results of a planned safety analysis. | Journal of cancer research and clinical oncology 20120801 |
| Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune disease. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120801 |
| Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan. | Blood 20120712 |
| HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application. | Journal of pharmaceutical and biomedical analysis 20120325 |
| Treosulfan-based conditioning before hematopoietic SCT: more than a BU look-alike. | Bone marrow transplantation 20120101 |
| Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia. | Annals of hematology 20120101 |
| Low incidence and severity of oral mucositis in allogeneic stem cell transplantation after conditioning with treosulfan and fludarabine. | European journal of haematology 20120101 |
| Treosulfan-based preparative regimens for allo-HSCT in childhood hematological malignancies: a retrospective study on behalf of the EBMT pediatric diseases working party. | Bone marrow transplantation 20111201 |
| CD40 ligand deficiency with grade III liver fibrosis, transplanted by a treosulphan-based conditioning regimen. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20111001 |
| Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial. | Haematologica 20110901 |
| Treosulfan-based conditioning regimens for hematopoietic stem cell transplantation in children with primary immunodeficiency: United Kingdom experience. | Blood 20110421 |
| Retrospective analysis of treosulfan-based conditioning in comparison with standard conditioning in patients with myelodysplastic syndrome. | Bone marrow transplantation 20110401 |
| Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies. | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110301 |
| Age has no significant impact on overall survival and on treatment tolerability in relapsed stage IV cutaneous malignant melanoma patients receiving Cisplatin, Gemcitabine, and Treosulfan. | American journal of clinical oncology 20110201 |
| High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation. | Expert opinion on investigational drugs 20101001 |
| Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy. | British journal of cancer 20100824 |
| The role of reduced intensity preparative regimens in patients with thalassemia given hematopoietic transplantation. | Annals of the New York Academy of Sciences 20100801 |
| Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100710 |
| Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC. | International journal of hematology 20091201 |
| Chemotherapy: Topotecan or treosulfan--that is the question. | Nature reviews. Clinical oncology 20091001 |
| Topotecan versus treosulfan, an alkylating agent, in patients with epithelial ovarian cancer and relapse within 12 months following 1st-line platinum/paclitaxel chemotherapy. A prospectively randomized phase III trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR). | Gynecologic oncology 20090801 |
| Diffusion-weighted imaging as predictor of therapy response in an animal model of Ewing sarcoma. | Investigative radiology 20090501 |
| Preclinical analysis of treosulfan in combination with total body irradiation as conditioning regimen prior to bone marrow transplantation in rats. | Immunopharmacology and immunotoxicology 20090101 |
| Treosulphan as an alternative to busulphan for myeloablative conditioning in paediatric allogeneic transplantation. | British journal of haematology 20081201 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major. | British journal of haematology 20081101 |
| Cytotoxic effects of treosulfan and busulfan against leukemic cells of pediatric patients. | Cancer chemotherapy and pharmacology 20081001 |
| Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT. | Bone marrow transplantation 20081001 |
| Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients. | Cancer chemotherapy and pharmacology 20080901 |
| Treosulfan/fludarabine as an allogeneic hematopoietic stem cell transplant conditioning regimen for high-risk patients. | American journal of hematology 20080901 |
| Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma. | Cancer chemotherapy and pharmacology 20080601 |
| Treosulfan and fludarabine low-toxicity conditioning for allogeneic haematopoietic stem cell transplantation in chronic myeloid leukaemia. | British journal of haematology 20080601 |
| Treosulfan-containing regimens achieve high rates of engraftment associated with low transplant morbidity and mortality in children with non-malignant disease and significant co-morbidities. | British journal of haematology 20080601 |
| Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia. | Anticancer research 20080101 |
| Lessons of war: progress in transplant conditioning regimens. | Leukemia & lymphoma 20071201 |
| Fludarabine and treosulfan: a novel modified myeloablative regimen for allogeneic hematopoietic stem-cell transplantation with effective antileukemia activity in patients with acute myeloid leukemia and myelodysplastic syndromes. | Leukemia & lymphoma 20071201 |
| Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients. | British journal of cancer 20071119 |
| Treosulfan impedes the migration of immunocompetent cells. | Journal of neurology 20071001 |
| Engraftment kinetics and hematopoietic chimerism after reduced-intensity conditioning with fludarabine and treosulfan before allogeneic stem cell transplantation. | Annals of hematology 20070801 |
| Treatment of active secondary progressive multiple sclerosis with treosulfan. | Journal of neurology 20070701 |
| Comment on 'determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation' by F.K. Glowka et al. [J. Chromatogr. B 850 (2007) 569-574]. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615 |
| Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501 |
| Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma. | Bone marrow transplantation 20070401 |
| Substitution of cyclophosphamide and busulfan by fludarabine, treosulfan and melphalan in a preparative regimen for children and adolescents with Shwachman-Diamond syndrome. | Bone marrow transplantation 20070201 |
| Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia. | Anticancer research 20070101 |
| Medical treatment of uveal melanoma. | Tumori 20070101 |
| Cytotoxic effects of treosulfan on prostate cancer cell lines. | Anticancer research 20070101 |
| A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma. | Annals of oncology : official journal of the European Society for Medical Oncology 20061201 |
| In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060915 |
| Cytotoxicity of treosulfan and busulfan on pediatric tumor cell lines. | Anti-cancer drugs 20060701 |
| A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma. | Melanoma research 20060601 |
| Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS). | Bone marrow transplantation 20060201 |
| Unrelated donor bone marrow transplantation with treosulfan-based myeloablative conditioning for paroxysmal nocturnal hemoglobinuria--successful treatment despite multiple transplant-related risk factors for hemolysis including major Kidd group incompatibility. | Bone marrow transplantation 20060101 |
| A randomised comparison of treosulfan and carboplatin in patients with ovarian cancer: a study by the Scottish Gynaecological Cancer Trials Group (SGCTG). | European journal of cancer (Oxford, England : 1990) 20060101 |
| Myeloablative and immunosuppressive properties of treosulfan in mice. | Experimental hematology 20060101 |
| Evaluation of chemosensitivity of human bone marrow stromal cells--differences between common chemotherapeutic drugs. | Anticancer research 20060101 |
| Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment excluding antibodies or irradiation use. | Cell transplantation 20060101 |
| Treosulfan, cyclophosphamide and antithymocyte globulin for allogeneic hematopoietic cell transplantation in acquired severe aplastic anemia. | Annals of transplantation 20060101 |
| The results of treatment of epithelial ovarian cancer after centralisation of primary surgery. Results from North Jutland, Denmark. | Gynecologic oncology 20051201 |
| A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma. | Melanoma research 20051001 |
| [Allogeneic blood stem cell transplantation in high-risk patients after conditioning with treosulfan and fludarabine]. | Deutsche medizinische Wochenschrift (1946) 20050923 |
| Two allogeneic hematopoietic stem cell transplantations without the use of blood-product support. | Haematologica 20050901 |
| Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients. | British journal of cancer 20050606 |
| Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma. | Melanoma research 20050601 |
| Treosulfan and gemcitabine. | Journal of cancer research and clinical oncology 20050501 |
| Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications. | Bone marrow transplantation 20050201 |
| Myeloablative conditioning in myelofibrosis using i.v. treosulfan and autologous peripheral blood progenitor cell transplantation with high doses of CD34+ cells results in hematologic responses - follow-up of three patients. | Haematologica 20050201 |
| [Metronomic chemotherapy. Should we change our thinking in the treatment of advanced tumors?]. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050101 |
| Myeloablative conditioning in myelofibrosis using i.v. treosulfan and autologous peripheral blood progenitor cell transplantation with high doses of CD34+ cells results in hematologic responses. A follow-up of three patients. | Haematologica 20050101 |
| Pharmacokinetics of treosulfan in a myeloablative combination with cyclophosphamide prior to allogeneic hematopoietic stem cell transplantation. | International journal of clinical pharmacology and therapeutics 20041101 |
| Treosulfan based conditioning for autologous and allogeneic hematopoietic stem cell transplantation. | International journal of clinical pharmacology and therapeutics 20041101 |
| High-dose treosulfan in patients with relapsed or refractory high-grade lymphoma receiving tandem autologous blood stem cell transplantation. | Bone marrow transplantation 20040901 |
| A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours. | European journal of cancer (Oxford, England : 1990) 20040901 |
| Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma. | Journal of cancer research and clinical oncology 20040701 |
| Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model. | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040401 |
| Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation. | Blood 20040115 |
| Toward a myeloablative regimen with clinical potential: II. Treosulfan induces specific skin graft tolerance across haploidentical MHC barriers. | Bone marrow transplantation 20040101 |
| Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1. | Experimental hematology 20040101 |
| Treosulfan/fludarabine: a new conditioning regimen in allogeneic transplantation. | Annals of hematology 20040101 |
| The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours. | BMC cancer 20040101 |
| Metronomic oral low-dose treosulfan chemotherapy combined with cyclooxygenase-2 inhibitor in pretreated advanced melanoma: a pilot study. | Cancer chemotherapy and pharmacology 20031101 |
| Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes. | Journal of neuroimmunology 20031101 |
| Treosulfan is an effective inducer of cell death in myeloma cell lines and primary myeloma cells from patients. | British journal of haematology 20030901 |
| Towards a myeloablative regimen with clinical potential: I. Treosulfan conditioning and bone marrow transplantation allow induction of donor-specific tolerance for skin grafts across full MHC barriers. | Bone marrow transplantation 20030701 |
| Treosulfan and gemcitabine in metastatic uveal melanoma patients: results of a multicenter feasibility study. | Anti-cancer drugs 20030601 |
| Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL). | European journal of cancer (Oxford, England : 1990) 20030401 |
| Femoral head necrosis in three patients with relapsed ovarian cancer receiving high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. | Bone marrow transplantation 20030301 |
| Second-line chemotherapy of metastatic malignant melanoma with intravenous treosulfan: a phase II multicentre trial. | Melanoma research 20030201 |
| Treosulfan in the treatment of metastatic melanoma: from chemosensitivity testing to clinical trials. | Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20030101 |
| Neoadjuvant gemcitabine/treosulfan chemotherapy for newly diagnosed glioblastoma: a phase II study. | Journal of neuro-oncology 20020901 |
| CD95/CD95 ligand-independent potentiation of treosulfan cytotoxicity by BSO in malignant glioma cells in vitro and in vivo. | International journal of oncology 20020701 |
| Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer. | Anti-cancer drugs 20020701 |
| Rationale for combination therapy of chronic myelogenous leukaemia with imatinib and irradiation or alkylating agents: implications for pretransplant conditioning. | British journal of cancer 20020506 |
| The role of gemcitabine-based doublets in the management of ovarian carcinoma. | Seminars in oncology 20020201 |
| Chemotherapy versus hormonal treatment in platinum- and paclitaxel-refractory ovarian cancer: a randomised trial of the German Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group Ovarian Cancer. | Annals of oncology : official journal of the European Society for Medical Oncology 20020201 |
| Individualized long-term chemotherapy for recurrent ovarian cancer after failing high-dose treatment. | Anti-cancer drugs 20020201 |
| Treosulfan in the treatment of advanced ovarian cancer: a randomised co-operative multicentre phase III-study. | Anticancer research 20020101 |
| Progression of Parkinson's disease with impairment of vision under carboplatin/cyclophosphamide therapy for ovarian cancer. | Cancer chemotherapy and pharmacology 19980101 |