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JTC-801

CAS No.:
244218-51-7
Catalog Number:
AG00BF3X
Molecular Formula:
C26H26ClN3O2
Molecular Weight:
447.9565
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$119
- +
10mg
99%
1 week
United States
$173
- +
25mg
≥98%
1 week
United States
$339
- +
50mg
99%
1 week
United States
$473
- +
Product Description
Catalog Number:
AG00BF3X
Chemical Name:
JTC-801
CAS Number:
244218-51-7
Molecular Formula:
C26H26ClN3O2
Molecular Weight:
447.9565
MDL Number:
MFCD06198707
IUPAC Name:
N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide;hydrochloride
InChI:
InChI=1S/C26H25N3O2.ClH/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25;/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30);1H
InChI Key:
NQLIYKXNAXKMBL-UHFFFAOYSA-N
SMILES:
CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C.Cl
UNII:
7I21WLZ2FP
Properties
Complexity:
577  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
447.171g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
447.963g/mol
Monoisotopic Mass:
447.171g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
77.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice. Pharmacology, biochemistry, and behavior 20111001
Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor. European journal of medicinal chemistry 20110401
Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. British journal of pharmacology 20090701
Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats. Pharmacology, biochemistry, and behavior 20090501
Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. Journal of anesthesia 20090101
Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians. Neuropeptides 20080601
[Prostaglandin and nociceptin/orphanin FQ]. Masui. The Japanese journal of anesthesiology 20071101
NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats. Neuropeptides 20070801
The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. The European journal of neuroscience 20060201
Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. European journal of pharmacology 20050314
A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists. European journal of medicinal chemistry 20041201
Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model. Neuroscience letters 20031120
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. The European journal of neuroscience 20030401
Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride. The Journal of pharmacology and experimental therapeutics 20021001
Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. British journal of pharmacology 20020101
4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. Journal of medicinal chemistry 20001130
Properties