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Home Other Building Blocks CS 7017

CS 7017

CAS No.:
223132-38-5
Catalog Number:
AG00BF3U
Molecular Formula:
C27H28Cl2N4O4S
Molecular Weight:
575.5066
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$654
- +
Product Description
Catalog Number:
AG00BF3U
Chemical Name:
CS 7017
CAS Number:
223132-38-5
Molecular Formula:
C27H28Cl2N4O4S
Molecular Weight:
575.5066
MDL Number:
MFCD13194772
IUPAC Name:
5-[[4-[[6-(4-amino-3,5-dimethylphenoxy)-1-methylbenzimidazol-2-yl]methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;dihydrochloride
InChI:
InChI=1S/C27H26N4O4S.2ClH/c1-15-10-20(11-16(2)25(15)28)35-19-8-9-21-22(13-19)31(3)24(29-21)14-34-18-6-4-17(5-7-18)12-23-26(32)30-27(33)36-23;;/h4-11,13,23H,12,14,28H2,1-3H3,(H,30,32,33);2*1H
InChI Key:
WFIOHOJEIMQCEG-UHFFFAOYSA-N
SMILES:
O=C1NC(=O)C(S1)Cc1ccc(cc1)OCc1nc2c(n1C)cc(cc2)Oc1cc(C)c(c(c1)C)N.Cl.Cl
Properties
Complexity:
782  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
574.121g/mol
Formal Charge:
0
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
575.505g/mol
Monoisotopic Mass:
574.121g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
134A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Correlation between activation of PPARγ and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones. Toxicology in vitro : an international journal published in association with BIBRA 20130801
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice. International journal of cancer 20080901
Anti-tumour activity of CS-7017, a selective peroxisome proliferator-activated receptor gamma agonist of thiazolidinedione class, in human tumour xenografts and a syngeneic tumour implant model. European journal of cancer (Oxford, England : 1990) 20080801
RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells. Molecular and cellular endocrinology 20060607
Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene 20060413
Properties