1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester
| Title | Journal |
|---|---|
| TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. | Archives of toxicology 20170401 |
| Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells. | Toxicology and applied pharmacology 20131215 |
| Treatment with anti-inflammatory drugs in community-acquired pneumonia. | Journal of internal medicine 20120701 |
| Differences in the pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, in rats and dogs. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| [Effects of several inhibitors of intracellular signaling on production of cytokines and signal proteins in RAW 264.7 cells cultivated with low dose ammonium]. | Biofizika 20120101 |
| Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades. | Expert opinion on therapeutic targets 20111201 |
| Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro. | Biopharmaceutics & drug disposition 20111001 |
| Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4. | Arthritis and rheumatism 20110601 |
| Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep. | Anesthesiology 20110501 |
| TAKEDA-143242 increased survival via reduced cytokines in porcine peritonitis. | The Journal of surgical research 20110401 |
| Lipopolysaccharide induces H1 receptor expression and enhances histamine responsiveness in human coronary artery endothelial cells. | Immunology 20110401 |
| Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis. | Shock (Augusta, Ga.) 20110201 |
| TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. | Molecular pharmacology 20110101 |
| Investigation of the unique metabolic fate of ethyl (6R)-6- [N- (2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242) in rats and dogs using two types of 14C-labeled compounds having different labeled positions. | Arzneimittel-Forschung 20110101 |
| Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20101001 |
| A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. | Critical care medicine 20100801 |
| Biomarkers as end points in clinical trials of severe sepsis: a garden of forking paths. | Critical care medicine 20100801 |
| Toll-like receptor 4 modulation as a strategy to treat sepsis. | Mediators of inflammation 20100101 |
| Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. | British journal of pharmacology 20090801 |
| The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious Guinea-pigs. | Clinical and experimental pharmacology & physiology 20090501 |
| TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. | European journal of pharmacology 20080414 |
| Novel cyclohexene derivatives as anti-sepsis agents: synthetic studies and inhibition of NO and cytokine production. | Bioorganic & medicinal chemistry 20080401 |
| Bench-to-bedside review: sepsis, severe sepsis and septic shock - does the nature of the infecting organism matter? | Critical care (London, England) 20080101 |
| Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. | European journal of pharmacology 20071001 |
| A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. | Molecular pharmacology 20060401 |
| Optically active cyclohexene derivative as a new antisepsis agent: an efficient synthesis of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242). | Chemical & pharmaceutical bulletin 20060101 |
| Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. | Journal of medicinal chemistry 20051117 |