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adoprazine

CAS No.:
222551-17-9
Catalog Number:
AG00BF1Z
Molecular Formula:
C24H24FN3O2
Molecular Weight:
405.4647
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$390
- +
10mg
98%
1 week
United States
$623
- +
50mg
98%
1 week
United States
$1557
- +
Product Description
Catalog Number:
AG00BF1Z
Chemical Name:
adoprazine
CAS Number:
222551-17-9
Molecular Formula:
C24H24FN3O2
Molecular Weight:
405.4647
MDL Number:
MFCD11973649
IUPAC Name:
1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]piperazine
InChI:
InChI=1S/C24H24FN3O2/c25-21-6-4-19(5-7-21)20-14-18(15-26-16-20)17-27-8-10-28(11-9-27)22-2-1-3-23-24(22)30-13-12-29-23/h1-7,14-16H,8-13,17H2
InChI Key:
IUVSEUFHPNITEQ-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)c1cncc(c1)CN1CCN(CC1)c1cccc2c1OCCO2
UNII:
7SNB18Q89D
Properties
Complexity:
537  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
405.185g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
405.473g/mol
Monoisotopic Mass:
405.185g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
37.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.7  
Literature
Title Journal
Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties. Psychopharmacology 20110801
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. Behavioural brain research 20091105
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. Journal of medicinal chemistry 20071018
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. Journal of medicinal chemistry 20070222
SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070101
Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060901
SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic. Chemical & pharmaceutical bulletin 20060901
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release. European journal of pharmacology 20060327
Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology 20060318
Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats. Neuropharmacology 20050801
Properties