Repertaxin
| Title | Journal |
|---|---|
| Chemokine receptor antagonists. | Journal of medicinal chemistry 20121126 |
| CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. | The Journal of clinical investigation 20121001 |
| Elevated interleukin-8 enhances prefrontal synaptic transmission in mice with persistent inflammatory pain. | Molecular pain 20120101 |
| Changes in expression of mRNA for interleukin-8 and effects of interleukin-8 receptor inhibitor in the spinal dorsal horn in a rat model of lumbar disc herniation. | Spine 20111201 |
| Progress in structure based drug design for G protein-coupled receptors. | Journal of medicinal chemistry 20110714 |
| Inhibition of CXCR1 and CXCR2 chemokine receptors attenuates acute inflammation, preserves gray matter and diminishes autonomic dysreflexia after spinal cord injury. | Spinal cord 20110301 |
| Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. | Biological & pharmaceutical bulletin 20110101 |
| CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury. | Hepatology (Baltimore, Md.) 20110101 |
| CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. | The Journal of clinical investigation 20100201 |
| Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression? | Breast cancer research : BCR 20100101 |
| A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5. | British journal of pharmacology 20091001 |
| Development and validation of an LC-MS/MS method for determination of methanesulfonamide in human urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715 |
| Novel role of CXCR2 in regulation of gamma-secretase activity. | ACS chemical biology 20081219 |
| Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice. | British journal of pharmacology 20081001 |
| The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. | Arthritis and rheumatism 20080801 |
| Platelet activating factor receptors drive CXC chemokine production, neutrophil influx and edema formation in the lungs of mice injected with Tityus serrulatus venom. | Toxicon : official journal of the International Society on Toxinology 20070901 |
| Reparixin, an inhibitor of CXCR2 function, attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord. | The Journal of pharmacology and experimental therapeutics 20070901 |
| Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. | Journal of medicinal chemistry 20070823 |
| Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. | American journal of respiratory and critical care medicine 20070301 |
| Reparixin, a specific interleukin-8 inhibitor, has no effects on inflammation during endotoxemia. | International journal of immunopathology and pharmacology 20070101 |
| The interleukin-8 (IL-8/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats. | Molecular medicine (Cambridge, Mass.) 20070101 |
| Chemokine MIP-2/CXCL2, acting on CXCR2, induces motor neuron death in primary cultures. | Neuroimmunomodulation 20070101 |
| Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog. | Xenobiotica; the fate of foreign compounds in biological systems 20060501 |
| 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. | Journal of medicinal chemistry 20050630 |
| Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia. | Cytokine 20050507 |
| Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. | Kidney international 20050501 |
| Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. | Journal of medicinal chemistry 20050407 |
| Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2. | Biochemical pharmacology 20050201 |
| Neutrophil recruitment in the reperfused-injured rat liver was effectively attenuated by repertaxin, a novel allosteric noncompetitive inhibitor of CXCL8 receptors: a therapeutic approach for the treatment of post-ischemic hepatic syndromes. | International journal of immunopathology and pharmacology 20050101 |
| Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. | British journal of pharmacology 20040901 |
| Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. | Proceedings of the National Academy of Sciences of the United States of America 20040810 |